4NFD
 
 | | Structure of PILR L108W mutant in complex with sialic acid | | 分子名称: | N-acetyl-alpha-neuraminic acid, Paired immunoglobulin-like type 2 receptor beta | | 著者 | Lu, Q, Lu, G, Qi, J, Li, Y, Zhang, Y, Wang, H, Fan, Z, Yan, J, Gao, G.F. | | 登録日 | 2013-10-31 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.708 Å) | | 主引用文献 | PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid
Proc.Natl.Acad.Sci.USA, 111, 2014
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4NFB
 | | Structure of paired immunoglobulin-like type 2 receptor (PILR ) | | 分子名称: | Paired immunoglobulin-like type 2 receptor alpha | | 著者 | Lu, Q, Lu, G, Qi, J, Li, Y, Zhang, Y, Wang, H, Fan, Z, Yan, J, Gao, G. | | 登録日 | 2013-10-31 | | 公開日 | 2014-05-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid
Proc.Natl.Acad.Sci.USA, 111, 2014
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1L3K
 | | UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1 | | 分子名称: | HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 | | 著者 | Vitali, J, Ding, J, Jiang, J, Zhang, Y, Krainer, A.R, Xu, R.-M. | | 登録日 | 2002-02-27 | | 公開日 | 2002-04-17 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.
Nucleic Acids Res., 30, 2002
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7VAB
 | | Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex | | 分子名称: | CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | 登録日 | 2021-08-28 | | 公開日 | 2022-03-02 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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7VBI
 | | Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | 登録日 | 2021-08-31 | | 公開日 | 2022-03-02 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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6OS9
 | | human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | | 登録日 | 2019-05-01 | | 公開日 | 2019-07-10 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
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8G59
 | | Cryo-EM structure of the TUG891 bound GPR120-Giq complex | | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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7VBH
 | | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | 登録日 | 2021-08-31 | | 公開日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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5XXH
 | | Crystal Structure Analysis of the CBP | | 分子名称: | (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, CREB-binding protein, ... | | 著者 | Xiang, Q, Zhang, Y, Wang, C, Song, M. | | 登録日 | 2017-07-04 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.
Eur J Med Chem, 147, 2018
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4N1Z
 | | Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1222 | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Liu, Y.L, Xia, Y, Zhang, Y, Verma, I, Oldfield, E. | | 登録日 | 2013-10-04 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.
Sci Transl Med, 6, 2014
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7V35
 | | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GCGR-Gs complex | | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W. | | 登録日 | 2021-08-10 | | 公開日 | 2022-03-02 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Nat Commun, 13, 2022
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4NFC
 | | Structure of paired immunoglobulin-like type 2 receptor (PILR ) | | 分子名称: | Paired immunoglobulin-like type 2 receptor beta | | 著者 | Lu, Q, Lu, G, Qi, J, Li, Y, Zhang, Y, Wang, H, Fan, Z, Yan, J, Gao, G.F. | | 登録日 | 2013-10-31 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | PILR alpha and PILR beta have a siglec fold and provide the basis of binding to sialic acid
Proc.Natl.Acad.Sci.USA, 111, 2014
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8HNC
 | | Cryo-EM structure of human OATP1B1 in complex with bilirubin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | | 著者 | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023
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8HNB
 | | Cryo-EM structure of human OATP1B1 in apo state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1 | | 著者 | Shan, Z, Yang, X, Zhang, Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023
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8HNH
 | | Cryo-EM structure of human OATP1B1 in complex with simeprevir | | 分子名称: | (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Shan, Z, Yang, X, Zhang, Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023
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8HND
 | | Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1, ... | | 著者 | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023
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3QH2
 | | Crystal structure of TenI from Bacillus subtilis complexed with product cThz-P | | 分子名称: | 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, Regulatory protein tenI, SULFATE ION | | 著者 | Han, Y, Zhang, Y, Hazra, A, Chatterjee, A, Lai, R, Begley, T.P, Ealick, S.E. | | 登録日 | 2011-01-25 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.231 Å) | | 主引用文献 | A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase.
J.Am.Chem.Soc., 133, 2011
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8ID6
 | | Cryo-EM structure of the oleic acid bound GPR120-Gi complex | | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID9
 | | Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | | 分子名称: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID4
 | | Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID3
 | | Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | | 分子名称: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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8ID8
 | | Cryo-EM structure of the TUG891 bound GPR120-Gi complex | | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | | 登録日 | 2023-02-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
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3C3I
 | | Evolution of chlorella virus dUTPase | | 分子名称: | DEOXYURIDINE-5'-DIPHOSPHATE, Deoxyuridine triphosphatase, MAGNESIUM ION | | 著者 | Yamanishi, M, Homma, K, Zhang, Y, Etten, L.V.J, Moriyama, H. | | 登録日 | 2008-01-28 | | 公開日 | 2009-02-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystallization and crystal-packing studies of Chlorella virus deoxyuridine triphosphatase.
Acta Crystallogr.,Sect.F, 65, 2009
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1NW3
 | | Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase | | 分子名称: | ACETATE ION, S-ADENOSYLMETHIONINE, SULFATE ION, ... | | 著者 | Min, J.R, Feng, Q, Li, Z.H, Zhang, Y, Xu, R.M. | | 登録日 | 2003-02-05 | | 公開日 | 2003-03-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase
Cell(Cambridge,Mass.), 112, 2003
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1K4V
 | | 1.53 A Crystal Structure of the Beta-Galactoside-alpha-1,3-galactosyltransferase in Complex with UDP | | 分子名称: | GLYCEROL, MANGANESE (II) ION, N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE, ... | | 著者 | Boix, E, Swaminathan, G.J, Zhang, Y, Natesh, R, Brew, K, Acharya, K.R. | | 登録日 | 2001-10-09 | | 公開日 | 2002-04-10 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus.
J.Biol.Chem., 276, 2001
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