4D81
| Metallosphera sedula Vps4 crystal structure | 分子名称: | AAA ATPase, central domain protein, ADENOSINE-5'-DIPHOSPHATE | 著者 | Caillat, C, Macheboeuf, P, Wu, Y, McCarthy, A.A, Boeri-Erba, E, Effantin, G, Gottlinger, H.G, Weissenhorn, W, Renesto, P. | 登録日 | 2014-12-02 | 公開日 | 2015-11-25 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Asymmetric Ring Structure of Vps4 Required for Escrt-III Disassembly. Nat.Commun., 6, 2015
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4DSO
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, BENZAMIDINE, GLYCEROL, ... | 著者 | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | 登録日 | 2012-02-19 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DSU
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | 分子名称: | BENZIMIDAZOLE, GTPase KRas, isoform 2B, ... | 著者 | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | 登録日 | 2012-02-19 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DST
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | 分子名称: | 1,2-ETHANEDIOL, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, ACETATE ION, ... | 著者 | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | 登録日 | 2012-02-19 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4DSN
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity | 分子名称: | 1,2-ETHANEDIOL, GTPase KRas, isoform 2B, ... | 著者 | Oh, A, Maurer, T, Garrenton, L.S, Pitts, K, Anderson, D.J, Skelton, N.J, Fauber, B.P, Pan, B, Malek, S, Stokoe, D, Ludlam, M, Bowman, K.K, Wu, J, Giannetti, A.M, Starovasnik, M.A, Mellman, I, Jackson, P.K, Ruldolph, J, Fang, G, Wang, W. | 登録日 | 2012-02-19 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109, 2012
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2R17
| Functional architecture of the retromer cargo-recognition complex | 分子名称: | GLYCEROL, Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | 著者 | Hierro, A, Rojas, A.L, Rojas, R, Murthy, N, Effantin, G, Kajava, A.V, Steven, A.C, Bonifacino, J.S, Hurley, J.H. | 登録日 | 2007-08-22 | 公開日 | 2007-10-30 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Functional architecture of the retromer cargo-recognition complex. Nature, 449, 2007
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7ZCH
| CHMP2A-CHMP3 heterodimer (410 Angstrom diameter) | 分子名称: | Charged multivesicular body protein 2a, Charged multivesicular body protein 3 | 著者 | Azad, K, Desfosses, A, Effantin, G, Schoehn, G, Weissenhorn, W. | 登録日 | 2022-03-28 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage. Nat.Struct.Mol.Biol., 30, 2023
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7ZCG
| CHMP2A-CHMP3 heterodimer (430 Angstrom diameter) | 分子名称: | Charged multivesicular body protein 2a, Charged multivesicular body protein 3 | 著者 | Azad, K, Desfosses, A, Effantin, G, Schoehn, G, Weissenhorn, W. | 登録日 | 2022-03-28 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage. Nat.Struct.Mol.Biol., 30, 2023
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5T84
| HIV-1 protease, unbound subtype B L63P construct | 分子名称: | Protease | 著者 | Liu, Z, Norell, J, Mahon, B, Poole, K, McKenna, R, Fanucci, G. | 登録日 | 2016-09-06 | 公開日 | 2017-09-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Single mutation, L63P, capable of shutting down the flaps of HIV-1 protease To Be Published
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7K7G
| nucleosome and Gal4 complex | 分子名称: | Centromere DNA-binding protein complex CBF3 subunit B, DNA (147-MER), Histone H2A.1, ... | 著者 | Ruifang, G, Yawen, B. | 登録日 | 2020-09-22 | 公開日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun, 12, 2021
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7K79
| CBF3 | 分子名称: | Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1 | 著者 | Ruifang, G, Yawen, B. | 登録日 | 2020-09-22 | 公開日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun, 12, 2021
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7K78
| antibody and nucleosome complex | 分子名称: | Cse4, DNA (136-MER), Histone H2A.1, ... | 著者 | Ruifang, G, Yawen, B. | 登録日 | 2020-09-22 | 公開日 | 2021-03-31 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun, 12, 2021
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5Z6Q
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5NC5
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5O66
| Asymmetric AcrABZ-TolC | 分子名称: | Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, ... | 著者 | Du, D, Luisi, B.F. | 登録日 | 2017-06-05 | 公開日 | 2017-06-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife, 6, 2017
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8XEP
| Crystal structure of a Legionella pneumophila type IV effector in complex with ubiquitin | 分子名称: | SULFATE ION, Type IV effector MavL, Ubiquitin | 著者 | Tan, J.X, Wang, X.F, Zhou, Y, Zhu, Y.Q. | 登録日 | 2023-12-12 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling. Nature, 631, 2024
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7EZT
| The structure and functional mechanism of nucleotide regulated acetylhexosaminidase Am2136 from Akkermansia muciniphila | 分子名称: | Beta-N-acetylhexosaminidase, MAGNESIUM ION | 著者 | Bao, R, Li, C.C, Tang, X.Y, Zhu, Y.B, Song, Y.J, Zhao, N.L, Huang, Q, Mou, X.Y, Luo, G.H, Liu, T.G. | 登録日 | 2021-06-02 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Nucleotide binding as an allosteric regulatory mechanism for Akkermansia muciniphila beta- N -acetylhexosaminidase Am2136. Gut Microbes, 14, 2022
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8EC0
| III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... | 著者 | Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. | 登録日 | 2022-08-31 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex. Nat Commun, 14, 2023
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8E7S
| III2IV2 respiratory supercomplex from Saccharomyces cerevisiae with 4 bound UQ6 | 分子名称: | (5S,11R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, ... | 著者 | Hryc, C.F, Mileykovskaya, E, Baker, M, Dowhan, W. | 登録日 | 2022-08-24 | 公開日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex. Nat Commun, 14, 2023
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6BO4
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6BO5
| TRPV2 ion channel in partially closed state | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Dosey, T.L, Wang, Z. | 登録日 | 2017-11-18 | 公開日 | 2018-12-05 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat.Struct.Mol.Biol., 26, 2019
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8JO4
| Cryo-EM structure of a Legionella effector complexed with actin and ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Zhou, X.T, Wang, X.F, Tan, J.X, Zhu, Y.Q. | 登録日 | 2023-06-07 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling. Nature, 631, 2024
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8JO3
| Cryo-EM structure of a Legionella effector complexed with actin and AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Zhou, X.T, Wang, X.F, Tan, J.X, Zhu, Y.Q. | 登録日 | 2023-06-07 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling. Nature, 631, 2024
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3GOL
| HCV NS5b polymerase in complex with 1,5 benzodiazepine inhibitor (R)-11d | 分子名称: | (11R)-10-acetyl-11-(2,4-dichlorophenyl)-6-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one, MAGNESIUM ION, RNA-directed RNA polymerase | 著者 | Nyanguile, O, De Bondt, H. | 登録日 | 2009-03-19 | 公開日 | 2009-06-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | 1,5-Benzodiazepine inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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4DRU
| HCV NS5B in complex with macrocyclic INDOLE INHIBITOR | 分子名称: | 13-cyclohexyl-3-methoxy-17,22-dimethyl-7H-10,6-(methanoiminothioiminobutanoiminomethano)indolo[2,1-a][2]benzazepine-14,23-dione 16,16-dioxide, GLYCEROL, RNA-directed RNA polymerase, ... | 著者 | Cummings, M.D, Vendeville, S. | 登録日 | 2012-02-17 | 公開日 | 2012-04-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties. Angew.Chem.Int.Ed.Engl., 51, 2012
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