4Y2U
| Structure of soluble epoxide hydrolase in complex with tert-butyl 1,2,3,4-tetrahydroquinolin-3-ylcarbamate | 分子名称: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, tert-butyl (3R)-1,2,3,4-tetrahydroquinolin-3-ylcarbamate | 著者 | Amano, Y, Yamaguchi, T. | 登録日 | 2015-02-10 | 公開日 | 2015-05-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening Bioorg.Med.Chem., 23, 2015
|
|
4Y2P
| |
4Y2T
| |
4Y2V
| |
4Y2S
| |
3W4K
| Crystal Structure of human DAAO in complex with coumpound 13 | 分子名称: | 3-hydroxy-6-(2-phenylethyl)pyridazin-4(1H)-one, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Hondo, T, Warizaya, M, Niimi, T, Namatame, I, Yamaguchi, T, Nakanishi, K, Hamajima, T, Harada, K, Sakashita, H, Matsumoto, Y, Orita, M, Watanabe, T, Takeuchi, M. | 登録日 | 2013-01-09 | 公開日 | 2013-05-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | 4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors. J.Med.Chem., 56, 2013
|
|
3W4J
| Crystal Structure of human DAAO in complex with coumpound 12 | 分子名称: | 3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Hondo, T, Warizaya, M, Niimi, T, Namatame, I, Yamaguchi, T, Nakanishi, K, Hamajima, T, Harada, K, Sakashita, H, Matsumoto, Y, Orita, M, Watanabe, T, Takeuchi, M. | 登録日 | 2013-01-09 | 公開日 | 2013-05-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | 4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors. J.Med.Chem., 56, 2013
|
|
3W4I
| Crystal Structure of human DAAO in complex with coumpound 8 | 分子名称: | D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, pyridine-2,3-diol | 著者 | Hondo, T, Warizaya, M, Niimi, T, Namatame, I, Yamaguchi, T, Nakanishi, K, Hamajima, T, Harada, K, Sakashita, H, Matsumoto, Y, Orita, M, Watanabe, T, Takeuchi, M. | 登録日 | 2013-01-09 | 公開日 | 2013-05-29 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | 4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors. J.Med.Chem., 56, 2013
|
|
3A5W
| Peroxiredoxin (wild type) from Aeropyrum pernix K1 (reduced form) | 分子名称: | Probable peroxiredoxin | 著者 | Nakamura, T, Kado, Y, Yamaguchi, T, Matsumura, H, Ishikawa, K, Inoue, T. | 登録日 | 2009-08-12 | 公開日 | 2009-10-27 | 最終更新日 | 2014-01-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of peroxiredoxin from Aeropyrum pernix K1 complexed with its substrate, hydrogen peroxide J.Biochem., 147, 2010
|
|
3WMG
| Crystal structure of an inward-facing eukaryotic ABC multidrug transporter G277V/A278V/A279V mutant in complex with an cyclic peptide inhibitor, aCAP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-binding cassette, sub-family B, ... | 著者 | Kodan, A, Yamaguchi, T, Nakatsu, T, Sakiyama, K, Hipolito, C.J, Fujioka, A, Hirokane, R, Ikeguchi, K, Watanabe, B, Hirtake, J, Kimura, Y, Suga, H, Ueda, K, Kato, H. | 登録日 | 2013-11-18 | 公開日 | 2014-04-30 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
3WME
| Crystal structure of an inward-facing eukaryotic ABC multidrug transporter | 分子名称: | ATP-binding cassette, sub-family B, member 1, ... | 著者 | Kodan, A, Yamaguchi, T, Nakatsu, T, Kato, H. | 登録日 | 2013-11-18 | 公開日 | 2014-03-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
3WMF
| Crystal structure of an inward-facing eukaryotic ABC multitrug transporter G277V/A278V/A279V mutant | 分子名称: | ATP-binding cassette, sub-family B, member 1, ... | 著者 | Kodan, A, Yamaguchi, T, Nakatsu, T, Kato, H. | 登録日 | 2013-11-18 | 公開日 | 2014-03-19 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
3WNX
| Crystal structure of ERGIC-53/MCFD2, Calcium/Man3-bound form | 分子名称: | CALCIUM ION, Multiple coagulation factor deficiency protein 2, Protein ERGIC-53, ... | 著者 | Satoh, T, Suzuki, K, Yamaguchi, T, Kato, K. | 登録日 | 2013-12-18 | 公開日 | 2014-01-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural Basis for Disparate Sugar-Binding Specificities in the Homologous Cargo Receptors ERGIC-53 and VIP36 Plos One, 9, 2014
|
|
3WKE
| Crystal structure of soluble epoxide hydrolase in complex with t-AUCB | 分子名称: | 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WK8
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 6-(trifluoromethyl)-1,3-benzothiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-17 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WKA
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WKB
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 4-benzyl-3,4-dihydroquinoxalin-2(1H)-one, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WK5
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-17 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WK9
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 5-(4-bromobenzyl)-1,3-thiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WKD
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-[2-(morpholin-4-yl)phenyl]thiophene-3-carboxamide, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WKC
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 4-{2,5-dimethyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrrol-3-yl}-1,3-thiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-18 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WK6
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | (5R)-5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-17 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WK4
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 1-[(1R)-1-cyclopropylethyl]-3-phenylurea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-17 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
3WK7
| Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | 分子名称: | 2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Amano, Y, Yamaguchi, T, Tanabe, E. | 登録日 | 2013-10-17 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
|
|
6A22
| Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T. | 分子名称: | 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | 著者 | Noguchi, M, Nomura, A, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2018-06-08 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction Sci Rep, 8, 2018
|
|