6A22
Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T.
Summary for 6A22
Entry DOI | 10.2210/pdb6a22/pdb |
Descriptor | Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, ... (4 entities in total) |
Functional Keywords | ternary complex, nuclear receptor, nuclear protein, nuclear protein-inhibitor complex, nuclear protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 131291.65 |
Authors | Noguchi, M.,Nomura, A.,Doi, S.,Yamaguchi, K.,Adachi, T. (deposition date: 2018-06-08, release date: 2018-12-12, Last modification date: 2023-11-22) |
Primary citation | Noguchi, M.,Nomura, A.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Maeda, K.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Crowe, P.,Tao, H.,Thacher, S.,Adachi, T. Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction Sci Rep, 8:17374-17374, 2018 Cited by PubMed: 30478402DOI: 10.1038/s41598-018-35783-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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