5VDQ
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6LHM
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![BU of 6lhm by Molmil](/molmil-images/mine/6lhm) | Structure of human PYCR2 | 分子名称: | Pyrroline-5-carboxylate reductase 2 | 著者 | Baburajendran, N. | 登録日 | 2019-12-09 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron, 107, 2020
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7T7A
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![BU of 7t7a by Molmil](/molmil-images/mine/7t7a) | Crystal Structure of Human SHOC2: A Leucine-Rich Repeat Protein | 分子名称: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, NITRATE ION | 著者 | Hajian, B, Lemke, C, Kwon, J, Bian, Y, Fuller, C, Aguirre, J. | 登録日 | 2021-12-14 | 公開日 | 2022-05-04 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
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8DS5
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![BU of 8ds5 by Molmil](/molmil-images/mine/8ds5) | X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex | 分子名称: | CADMIUM ION, CD27 antigen, MK-5890 Fab heavy chain, ... | 著者 | Fischmann, T.O. | 登録日 | 2022-07-21 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.926 Å) | 主引用文献 | Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy. J Immunother Cancer, 10, 2022
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7UPI
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![BU of 7upi by Molmil](/molmil-images/mine/7upi) | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | 分子名称: | CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... | 著者 | Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. | 登録日 | 2022-04-15 | 公開日 | 2022-05-04 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
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8QVS
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![BU of 8qvs by Molmil](/molmil-images/mine/8qvs) | Crystal structure of Ompk36 GD at 3500 eV based on a combination of spherical harmonics and analytical absorption corrections | 分子名称: | OmpK36, SULFATE ION | 著者 | Duman, R, Wagner, A, Beis, K, Wong, J. | 登録日 | 2023-10-18 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions. J.Appl.Crystallogr., 57, 2024
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8QUR
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![BU of 8qur by Molmil](/molmil-images/mine/8qur) | Crystal structure of Ompk36 GD at 3500 eV with no absorption corrections | 分子名称: | OmpK36, SULFATE ION | 著者 | Duman, R, Wagner, A, Beis, K, Wong, J. | 登録日 | 2023-10-16 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions. J.Appl.Crystallogr., 57, 2024
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8QUQ
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![BU of 8quq by Molmil](/molmil-images/mine/8quq) | Crystal structure of Ompk36 GD at 3500 eV based on spherical harmonics absorption corrections | 分子名称: | OmpK36, SULFATE ION | 著者 | Duman, R, Wagner, A, Beis, K, Wong, J. | 登録日 | 2023-10-16 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions. J.Appl.Crystallogr., 57, 2024
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8QVV
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![BU of 8qvv by Molmil](/molmil-images/mine/8qvv) | Crystal structure of Ompk36 GD at 3500 eV based on analytical absorption corrections | 分子名称: | OmpK36, SULFATE ION | 著者 | Duman, R, Wagner, A, Beis, K, Wong, J. | 登録日 | 2023-10-18 | 公開日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions. J.Appl.Crystallogr., 57, 2024
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4XX4
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4XX3
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3JSU
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![BU of 3jsu by Molmil](/molmil-images/mine/3jsu) | Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine, Dihydrofolate reductase-thymidylate synthase, ... | 著者 | Chitnumsub, P, Maneeruttanarungroj, C, Kamchonwongpaisan, S, Yuthavong, Y, Diagana, T.T. | 登録日 | 2009-09-11 | 公開日 | 2010-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate Antimicrob.Agents Chemother., 54, 2010
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4QPQ
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![BU of 4qpq by Molmil](/molmil-images/mine/4qpq) | Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM | 分子名称: | Relaxosome protein TraM, sbmA DNA1, sbmA DNA2 | 著者 | Peng, Y, Lu, J, Wong, J, Edwards, R.A, Frost, L.S, Glover, J.N.M. | 登録日 | 2014-06-24 | 公開日 | 2014-09-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.106 Å) | 主引用文献 | Mechanistic Basis of Plasmid-Specific DNA Binding of the F Plasmid Regulatory Protein, TraM. J.Mol.Biol., 426, 2014
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4QPO
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![BU of 4qpo by Molmil](/molmil-images/mine/4qpo) | Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM | 分子名称: | PHOSPHATE ION, Relaxosome protein TraM | 著者 | Peng, Y, Lu, J, Wong, J, Edwards, R.A, Frost, L.S, Glover, J.N.M. | 登録日 | 2014-06-24 | 公開日 | 2014-09-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Mechanistic Basis of Plasmid-Specific DNA Binding of the F Plasmid Regulatory Protein, TraM. J.Mol.Biol., 426, 2014
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6NAO
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![BU of 6nao by Molmil](/molmil-images/mine/6nao) | Discovery of a high affinity inhibitor of cGAS | 分子名称: | (1R,2S)-2-[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid, CYCLIC GMP-AMP SYNTHASE, ZINC ION | 著者 | Hall, J. | 登録日 | 2018-12-06 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12, 2017
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8GU0
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6RCP
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6RCK
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![BU of 6rck by Molmil](/molmil-images/mine/6rck) | Crystal structure of the OmpK36 GD insertion chimera from Klebsiella pneumonia | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE, ... | 著者 | Beis, K, Romano, M, Kwong, J. | 登録日 | 2019-04-11 | 公開日 | 2019-09-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.029 Å) | 主引用文献 | OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo. Nat Commun, 10, 2019
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6RD3
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5IZQ
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![BU of 5izq by Molmil](/molmil-images/mine/5izq) | Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183 | 分子名称: | Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid | 著者 | Ke, J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-03-25 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
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3L59
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![BU of 3l59 by Molmil](/molmil-images/mine/3l59) | Structure of BACE Bound to SCH710413 | 分子名称: | (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one, Beta-secretase 1, D(-)-TARTARIC ACID | 著者 | Strickland, C, Zhu, Z. | 登録日 | 2009-12-21 | 公開日 | 2010-02-16 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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3L58
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![BU of 3l58 by Molmil](/molmil-images/mine/3l58) | Structure of BACE Bound to SCH589432 | 分子名称: | Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE | 著者 | Strickland, C, Zhu, Z. | 登録日 | 2009-12-21 | 公開日 | 2010-02-16 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation J.Med.Chem., 53, 2010
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8TV4
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3WX6
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7D0P
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