3JSU
Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP
Summary for 3JSU
Entry DOI | 10.2210/pdb3jsu/pdb |
Related | 1J3I 1J3J 1J3K 3DG8 3DGA |
Descriptor | Dihydrofolate reductase-thymidylate synthase, 5-chloro-N~6~-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | rossmann fold, oxidoreductase, transferase |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 2 |
Total formula weight | 146643.09 |
Authors | Chitnumsub, P.,Maneeruttanarungroj, C.,Kamchonwongpaisan, S.,Yuthavong, Y.,Diagana, T.T. (deposition date: 2009-09-11, release date: 2010-07-28, Last modification date: 2023-11-01) |
Primary citation | Nzila, A.,Rottmann, M.,Chitnumsub, P.,Kiara, S.M.,Kamchonwongpaisan, S.,Maneeruttanarungroj, C.,Taweechai, S.,Yeung, B.K.,Goh, A.,Lakshminarayana, S.B.,Zou, B.,Wong, J.,Ma, N.L.,Weaver, M.,Keller, T.H.,Dartois, V.,Wittlin, S.,Brun, R.,Yuthavong, Y.,Diagana, T.T. Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate Antimicrob.Agents Chemother., 54:2603-2610, 2010 Cited by PubMed: 20350951DOI: 10.1128/AAC.01526-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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