1TD0
 
 | | Viral capsid protein SHP at pH 5.5 | | 分子名称: | Head decoration protein | | 著者 | Chang, C, Forrer, P, Ott, D, Wlodawer, A, Plueckthun, A. | | 登録日 | 2004-05-21 | | 公開日 | 2004-11-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Kinetic Stability and Crystal Structure of the Viral Capsid Protein SHP
J.Mol.Biol., 344, 2004
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8DVH
 | | Crystal structure of ATP-dependent Lon protease from Bacillus subtillis (BsLonBA) | | 分子名称: | Lon protease 2, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, SODIUM ION | | 著者 | Sekula, B, Li, M, Gustchina, A, Wlodawer, A. | | 登録日 | 2022-07-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases.
Int J Mol Sci, 23, 2022
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7HVP
 | | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR | | 分子名称: | HIV-1 PROTEASE, INHIBITOR ACE-SER-LEU-ASN-PHE-PSI(CH(OH)-CH2N)-PRO-ILE VME (JG-365) | | 著者 | Swain, A.L, Miller, M.M, Green, J, Rich, D.H, Schneider, J, Kent, S.B.H, Wlodawer, A. | | 登録日 | 1990-09-13 | | 公開日 | 1993-07-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.
Proc.Natl.Acad.Sci.USA, 87, 1990
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1NAG
 | | CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A | | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION | | 著者 | Danishefsky, A.T, Wlodawer, A, Kim, K.-S, Tao, F, Woodward, C. | | 登録日 | 1992-08-18 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A.
Protein Sci., 2, 1993
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3PGA
 | | STRUCTURAL CHARACTERIZATION OF PSEUDOMONAS 7A GLUTAMINASE-ASPARAGINASE | | 分子名称: | GLUTAMINASE-ASPARAGINASE | | 著者 | Lubkowski, J, Wlodawer, A, Ammon, H.L, Copeland, T.D, Swain, A.L. | | 登録日 | 1994-07-19 | | 公開日 | 1994-12-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural characterization of Pseudomonas 7A glutaminase-asparaginase.
Biochemistry, 33, 1994
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7UT3
 | | Crystal structure of complex of Fab, G10C with GalNAc-pNP | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-nitrophenyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside, Fab protein heavy chain, ... | | 著者 | Li, M, Wlodawer, A. | | 登録日 | 2022-04-26 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine O -GalNAcylation in Numerous Human Tissues and Cell Lines.
J.Am.Chem.Soc., 144, 2022
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7UPZ
 | | Structural basis for cell type specific DNA binding of C/EBPbeta: the case of cell cycle inhibitor p15INK4b promoter | | 分子名称: | CCAAT/enhancer-binding protein beta, DNA (5'-D(*AP*TP*TP*CP*TP*TP*AP*AP*GP*AP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*CP*TP*TP*TP*CP*TP*TP*AP*AP*GP*AP*A)-3') | | 著者 | Lountos, G.T, Cherry, S, Tropea, J.E, Wlodawer, A, Miller, M. | | 登録日 | 2022-04-18 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.487 Å) | | 主引用文献 | Structural basis for cell type specific DNA binding of C/EBP beta : The case of cell cycle inhibitor p15INK4b promoter.
J.Struct.Biol., 214, 2022
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4HVP
 | | Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution | | 分子名称: | HIV-1 PROTEASE, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide | | 著者 | Miller, M, Schneider, J, Sathyanarayana, B.K, Toth, M.V, Marshall, G.R, Clawson, L, Selk, L, Kent, S.B.H, Wlodawer, A. | | 登録日 | 1989-08-08 | | 公開日 | 1990-04-15 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution.
Science, 246, 1989
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9HFT
 | | Cryo-EM structure of human CDADC1 inactive mutant (E400A): hexamer with 5mdCTP bound in the active site | | 分子名称: | Cytidine and dCMP deaminase domain-containing protein 1, ZINC ION, [[(2~{R},3~{S},5~{R})-5-(4-azanyl-5-methyl-2-oxidanylidene-pyrimidin-1-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | | 著者 | Slyvka, A, Rathore, I, Yang, R, Kanai, T, Lountos, G, Wang, Z, Skowronek, K, Czarnocki-Cieciura, M, Wlodawer, A, Bochtler, M. | | 登録日 | 2024-11-18 | | 公開日 | 2025-04-30 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Activity and structure of human (d)CTP deaminase CDADC1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9HFR
 | | Cryo-EM structure of human CDADC1 inactive mutant (E400A): hexamer without a ligand | | 分子名称: | Cytidine and dCMP deaminase domain-containing protein 1, ZINC ION | | 著者 | Slyvka, A, Rathore, I, Yang, R, Kanai, T, Lountos, G, Wang, Z, Skowronek, K, Czarnocki-Cieciura, M, Wlodawer, A, Bochtler, M. | | 登録日 | 2024-11-18 | | 公開日 | 2025-04-30 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Activity and structure of human (d)CTP deaminase CDADC1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9HFQ
 | | Cryo-EM structure of human CDADC1 inactive mutant (E400A): trimer without a ligand | | 分子名称: | Cytidine and dCMP deaminase domain-containing protein 1, ZINC ION | | 著者 | Slyvka, A, Rathore, I, Yang, R, Kanai, T, Lountos, G, Wang, Z, Skowronek, K, Czarnocki-Cieciura, M, Wlodawer, A, Bochtler, M. | | 登録日 | 2024-11-18 | | 公開日 | 2025-04-30 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Activity and structure of human (d)CTP deaminase CDADC1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9HFS
 | | Cryo-EM structure of human CDADC1 inactive mutant (E400A): hexamer with dCTP bound in the active site | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Cytidine and dCMP deaminase domain-containing protein 1, ZINC ION | | 著者 | Slyvka, A, Rathore, I, Yang, R, Kanai, T, Lountos, G, Wang, Z, Skowronek, K, Czarnocki-Cieciura, M, Wlodawer, A, Bochtler, M. | | 登録日 | 2024-11-18 | | 公開日 | 2025-04-30 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Activity and structure of human (d)CTP deaminase CDADC1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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6FIV
 | | STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR | | 分子名称: | RETROPEPSIN, SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate | | 著者 | Li, M, Lee, T, Morris, G, Laco, G, Wong, C, Olson, A, Elder, J, Wlodawer, A, Gustchina, A. | | 登録日 | 1998-12-02 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
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5L04
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5N0H
 | | Crystal structure of NDM-1 in complex with hydrolyzed meropenem - new refinement | | 分子名称: | (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan yl-3-methyl-2,3-dihydro-1H-pyrrole-5-carboxylic acid, GLYCEROL, Metallo-beta-lactamase type 2, ... | | 著者 | Raczynska, J.E, Shabalin, I.G, Jaskolski, M, Minor, W, Wlodawer, A, King, D.T, Strynadka, N.C.J. | | 登録日 | 2017-02-03 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A close look onto structural models and primary ligands of metallo-beta-lactamases.
Drug Resist. Updat., 40, 2018
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8TN7
 | | The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a disaccharide | | 分子名称: | 2-amino-2-deoxy-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SULFATE ION, ... | | 著者 | Li, M, Wlodawer, A, Temme, S, Gildersleeve, J. | | 登録日 | 2023-08-01 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Cell Chem Biol, 31, 2024
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8TN5
 | | The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, complexed with a GlcNH2 | | 分子名称: | 2-amino-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SULFATE ION, ... | | 著者 | Li, M, Wlodawer, A, Temme, S, Gildersleeve, J. | | 登録日 | 2023-08-01 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Cell Chem Biol, 31, 2024
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8TN4
 | | The Crystal Structure of a human monoclonal antibody (aAb), termed TG10, used to study poly-N-acetyl-glucosamine broadly expressed in biofilm-forming pathogenclonal antibody | | 分子名称: | SODIUM ION, SULFATE ION, TG10, ... | | 著者 | Li, M, Wlodawer, A, Temme, S, Gildersleeve, J. | | 登録日 | 2023-08-01 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-06-18 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics.
Cell Chem Biol, 31, 2024
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9IX8
 | | Crystallization and structural characterization of phosphopentomutase from the hyperthermophilic archaeon Thermococcus kodakarensis | | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, GLYCEROL, Phosphopentomutase | | 著者 | Naz, Z, Lubkowski, T.J, Saleem, M, Rahman, M, Wlodawer, A, Rashid, N. | | 登録日 | 2024-07-26 | | 公開日 | 2024-12-18 | | 最終更新日 | 2025-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Biophysical Characterization of a Novel Phosphopentomutase from the Hyperthermophilic Archaeon Thermococcus kodakarensis .
Int J Mol Sci, 25, 2024
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9NWB
 | | Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-280-5I | | 分子名称: | (1R,2S,5S)-N-{(1S,2R)-1-hydroxy-1-(5-iodo-1,3-benzothiazol-2-yl)-3-[(3R)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, ORF1a polyprotein | | 著者 | Bulut, H, Hayashi, H, Hattori, S, Li, M, Das, D, Wlodawer, A, Tamamura, H, Mitsuya, H. | | 登録日 | 2025-03-21 | | 公開日 | 2025-06-04 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Impact of Single Halogen Atom Substitutions on Potency of Inhibitors Targeting SARS-CoV-2 Main Protease
To Be Published
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9NWA
 | | Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-277-5Cl | | 分子名称: | (1R,2S,5S)-N-{(1S,2S)-1-(5-chloro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | | 著者 | Bulut, H, Kuwata, N, Hayashi, H, Aoki, H, Das, D, Li, M, Wlodawer, A, Misumi, S, Tamamura, H, Mitsuya, H. | | 登録日 | 2025-03-21 | | 公開日 | 2025-06-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Impact of Single Halogen Atom Substitutions on Potency of Inhibitors Targeting SARS-CoV-2 Main Protease
To Be Published
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9NWC
 | | Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-276-5Br | | 分子名称: | (1R,2S,5S)-N-{(1S,2S)-1-(5-bromo-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-D-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | | 著者 | Bulut, H, Kuwata, N, Hayashi, H, Aoki, H, Hattori, S, Li, M, Das, D, Misumi, S, Wlodawer, A, Tamamura, H, Mitsuya, H. | | 登録日 | 2025-03-21 | | 公開日 | 2025-06-04 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Impact of Single Halogen Atom Substitutions on Potency of Inhibitors Targeting SARS-CoV-2 Main Protease
To Be Published
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8UOR
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19E) | | 分子名称: | 1,2-ETHANEDIOL, Asparaginase, CHLORIDE ION | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-20 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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8UP6
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19A) in complex with L-Asp | | 分子名称: | ASPARTIC ACID, Asparaginase, TETRAETHYLENE GLYCOL | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-21 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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8UP9
 | | Structure of atypical asparaginase from Rhodospirillum rubrum (mutant K19Q) | | 分子名称: | 1,2-ETHANEDIOL, Asparaginase, CHLORIDE ION, ... | | 著者 | Lubkowski, J, Wlodawer, A, Zhang, D. | | 登録日 | 2023-10-21 | | 公開日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short-chain L-asparaginases.
Protein Sci., 33, 2024
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