6KGQ
 
 | | LSD1-FCPA-MPE five-membered ring adduct model | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[4-[5-fluoranyl-2-(trifluoromethyl)phenyl]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Niwa, H, Sato, S, Handa, N, Umehara, T. | | 登録日 | 2019-07-12 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors.
Chemmedchem, 15, 2020
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6KGK
 | | LSD1-CoREST-S2101 five-membered ring adduct model | | 分子名称: | 3-[3,5-bis(fluoranyl)-2-phenylmethoxy-phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Niwa, H, Sato, S, Sengoku, S, Umehara, T, Yokoyama, S. | | 登録日 | 2019-07-12 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors.
Chemmedchem, 15, 2020
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6KGM
 | | LSD1-CoREST-S2116 five-membered ring adduct model | | 分子名称: | 3-[3,5-bis(fluoranyl)-2-phenylmethoxy-phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Niwa, H, Sato, S, Umehara, T. | | 登録日 | 2019-07-12 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors.
Chemmedchem, 15, 2020
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7FHS
 | | Crystal structure of DYRK1A in complex with RD0392 | | 分子名称: | (5~{Z})-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL | | 著者 | Kikuchi, M, Sumida, T, Hosoya, T, Kii, I, Umehara, T. | | 登録日 | 2021-07-30 | | 公開日 | 2022-03-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
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7FHT
 | | Crystal structure of DYRK1A in complex with RD0448 | | 分子名称: | (5~{Z})-5-[(3-ethynyl-4-methoxy-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | 著者 | Kikuchi, M, Sumida, Y, Hosoya, T, Kii, I, Umehara, T. | | 登録日 | 2021-07-30 | | 公開日 | 2022-03-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
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7EIF
 | | Crystal structure of GAS41 YEATS domain | | 分子名称: | GLYCEROL, YEATS domain-containing protein 4 | | 著者 | Kikuchi, M, Umehara, T. | | 登録日 | 2021-03-30 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7CDC
 | | Crystal structure of LSD1-CoREST in complex with PRSFLVRRP peptide | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | 著者 | Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. | | 登録日 | 2020-06-19 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.
J.Med.Chem., 64, 2021
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7CDF
 | | Crystal structure of LSD1-CoREST in complex with PRSFLVRRK peptide | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | 著者 | Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. | | 登録日 | 2020-06-19 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.
J.Med.Chem., 64, 2021
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7CDD
 | | Crystal structure of LSD1-CoREST in complex with PRSFLVRR peptide | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | 著者 | Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. | | 登録日 | 2020-06-19 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.
J.Med.Chem., 64, 2021
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7CDE
 | | Crystal structure of LSD1-CoREST in complex with PRSFLVRKR peptide | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | 著者 | Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. | | 登録日 | 2020-06-19 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.
J.Med.Chem., 64, 2021
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7CDG
 | | Crystal structure of LSD1-CoREST in complex with PRSFLVRRR peptide | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1A, ... | | 著者 | Kikuchi, M, Kitagawa, H, Sato, S, Umezawa, N, Higuchi, T, Umehara, T. | | 登録日 | 2020-06-19 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity.
J.Med.Chem., 64, 2021
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5B2J
 | | Human nucleosome containing CpG methylated DNA | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Fujii, Y, Wakamori, M, Umehara, T, Yokoyama, S. | | 登録日 | 2016-01-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.
Febs Open Bio, 6, 2016
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5AV8
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV9
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV6
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AVC
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AVB
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV5
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-11 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5B2I
 | | Human nucleosome containing CpG unmethylated DNA | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Fujii, Y, Wakamori, M, Umehara, T, Yokoyama, S. | | 登録日 | 2016-01-16 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.
Febs Open Bio, 6, 2016
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2RV0
 | | Solution structures of the DNA-binding domain (ZF12) of immune-related zinc-finger protein ZFAT | | 分子名称: | ZINC ION, Zinc finger protein ZFAT | | 著者 | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | | 登録日 | 2015-01-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015
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2RV6
 | | Solution structures of the DNA-binding domains (ZF2-ZF3-ZF4) of immune-related zinc-finger protein ZFAT | | 分子名称: | ZINC ION, Zinc finger protein ZFAT | | 著者 | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | | 登録日 | 2015-01-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015
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2RV2
 | | Solution structures of the DNA-binding domain (ZF14) of immune-related zinc-finger protein ZFAT | | 分子名称: | ZINC ION, Zinc finger protein ZFAT | | 著者 | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | | 登録日 | 2015-01-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015
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2RUT
 | | Solution structures of the DNA-binding domain (ZF2) of immune-related zinc-finger protein ZFAT | | 分子名称: | ZINC ION, Zinc finger protein ZFAT | | 著者 | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | | 登録日 | 2015-01-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.
J Struct Funct Genomics, 16, 2015
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2RUY
 | | Solution structures of the DNA-binding domain (ZF10) of immune-related zinc-finger protein ZFAT | | 分子名称: | ZINC ION, Zinc finger protein ZFAT | | 著者 | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | | 登録日 | 2015-01-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015
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2RUX
 | | Solution structures of the DNA-binding domain (ZF6) of immune-related zinc-finger protein ZFAT | | 分子名称: | ZINC ION, Zinc finger protein ZFAT | | 著者 | Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S. | | 登録日 | 2015-01-26 | | 公開日 | 2015-04-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015
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