7CDD

Crystal structure of LSD1-CoREST in complex with PRSFLVRR peptide

Summary for 7CDD

Entry DOI	10.2210/pdb7cdd/pdb
Descriptor	Lysine-specific histone demethylase 1A, REST corepressor 1, PRO-ARG-SER-PHE-LEU-VAL-ARG-ARG, ... (6 entities in total)
Functional Keywords	demethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription-inhibitor complex, oxidoreductase, oxidoreductase-transcription complex, oxidoreductase/transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	92186.96
Authors	Kikuchi, M.,Kitagawa, H.,Sato, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (deposition date: 2020-06-19, release date: 2021-06-23, Last modification date: 2023-11-29)
Primary citation	Kitagawa, H.,Kikuchi, M.,Sato, S.,Watanabe, H.,Umezawa, N.,Kato, M.,Hisamatsu, Y.,Umehara, T.,Higuchi, T. Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. J.Med.Chem., 64:3707-3719, 2021 Cited by PubMed: 33754721 DOI: 10.1021/acs.jmedchem.0c01371 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation