6KGQ

LSD1-FCPA-MPE five-membered ring adduct model

Summary for 6KGQ

Entry DOI	10.2210/pdb6kgq/pdb
Descriptor	Lysine-specific histone demethylase 1A, (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[4-[5-fluoranyl-2-(trifluoromethyl)phenyl]phenyl]propanal, ... (5 entities in total)
Functional Keywords	demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	75533.02
Authors	Niwa, H.,Sato, S.,Handa, N.,Umehara, T. (deposition date: 2019-07-12, release date: 2020-03-25, Last modification date: 2024-03-27)
Primary citation	Niwa, H.,Sato, S.,Handa, N.,Sengoku, T.,Umehara, T.,Yokoyama, S. Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors. Chemmedchem, 15:787-793, 2020 Cited by PubMed: 32166890 DOI: 10.1002/cmdc.202000014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation