5FQT
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![BU of 5fqt by Molmil](/molmil-images/mine/5fqt) | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 4. | 分子名称: | (E)-3-[4-(6-hydroxy-2-isobutyl-5-methyl-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid, ESTROGEN RECEPTOR ALPHA | 著者 | Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | 登録日 | 2015-12-14 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
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5FQV
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![BU of 5fqv by Molmil](/molmil-images/mine/5fqv) | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 5. | 分子名称: | (E)-3-[4-(6-hydroxy-2-isobutyl-7-methyl-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid, ESTROGEN RECEPTOR ALPHA | 著者 | Scott, J.S, bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | 登録日 | 2015-12-14 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
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5FQS
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![BU of 5fqs by Molmil](/molmil-images/mine/5fqs) | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 3. | 分子名称: | (E)-3-[4-(6-HYDROXY-2-ISOBUTYL-1-METHYL-3,4-DIHYDROISOQUINOLIN-1-YL)PHENYL]PROP-2-ENOIC ACID, ESTROGEN RECEPTOR | 著者 | Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | 登録日 | 2015-12-14 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
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5FQR
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![BU of 5fqr by Molmil](/molmil-images/mine/5fqr) | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 2. | 分子名称: | (E)-3-[4-[(1R)-6-HYDROXY-2-ISOBUTYL-3,4-DIHYDRO-1H-ISOQUINOLIN-1-YL]PHENYL]PROP-2-ENOIC ACID, ESTROGEN RECEPTOR | 著者 | Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | 登録日 | 2015-12-14 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
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5FQP
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![BU of 5fqp by Molmil](/molmil-images/mine/5fqp) | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 1. | 分子名称: | (E)-3-[4-[(1R,3R)-6-hydroxy-2-isobutyl-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid, ESTROGEN RECEPTOR ALPHA | 著者 | Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D. | 登録日 | 2015-12-14 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. Acs Med.Chem.Lett., 7, 2016
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3TTF
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![BU of 3ttf by Molmil](/molmil-images/mine/3ttf) | Crystal structure of E. coli HypF with AMP and carbamoyl phosphate | 分子名称: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Transcriptional regulatory protein, ... | 著者 | Petkun, S, Shi, R, Li, Y, Cygler, M. | 登録日 | 2011-09-14 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure, 19, 2011
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3TSQ
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![BU of 3tsq by Molmil](/molmil-images/mine/3tsq) | Crystal structure of E. coli HypF with ATP and Carbamoyl phosphate | 分子名称: | 5'-O-[(S)-(carbamoyloxy)(hydroxy)phosphoryl]adenosine, MAGNESIUM ION, Transcriptional regulatory protein, ... | 著者 | Petkun, S, Shi, R, Li, Y, Cygler, M. | 登録日 | 2011-09-13 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure, 19, 2011
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3TSP
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![BU of 3tsp by Molmil](/molmil-images/mine/3tsp) | Crystal structure of E. coli HypF | 分子名称: | MAGNESIUM ION, Transcriptional regulatory protein, ZINC ION | 著者 | Petkun, S, Shi, R, Li, Y, Cygler, M. | 登録日 | 2011-09-13 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure, 19, 2011
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3TTC
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![BU of 3ttc by Molmil](/molmil-images/mine/3ttc) | Crystal structure of E. coli HypF with ADP and carbamoyl phosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transcriptional regulatory protein, ... | 著者 | Petkun, S, Shi, R, Li, Y, Cygler, M. | 登録日 | 2011-09-14 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure, 19, 2011
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3TSU
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![BU of 3tsu by Molmil](/molmil-images/mine/3tsu) | Crystal structure of E. coli HypF with AMP-PNP and carbamoyl phosphate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Petkun, S, Shi, R, Li, Y, Cygler, M. | 登録日 | 2011-09-13 | 公開日 | 2011-12-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites. Structure, 19, 2011
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6RPY
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![BU of 6rpy by Molmil](/molmil-images/mine/6rpy) | Cytokine receptor-like factor 3 C-terminus residues 174-442: Hg-SAD derivative | 分子名称: | Cytokine receptor-like factor 3, MERCURY (II) ION | 著者 | Mifsud, R.W, Yan, Y, Bennett, C, Read, R.J. | 登録日 | 2019-05-15 | 公開日 | 2020-03-25 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia. Blood, 139, 2022
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6RPZ
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![BU of 6rpz by Molmil](/molmil-images/mine/6rpz) | |
6RPX
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![BU of 6rpx by Molmil](/molmil-images/mine/6rpx) | |
6ZOQ
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![BU of 6zoq by Molmil](/molmil-images/mine/6zoq) | Oestrogen receptor ligand binding domain in complex with compound 16 | 分子名称: | Estrogen receptor, ~{N}-[4-[(6~{S},8~{R})-7-[(1-fluoranylcyclopropyl)methyl]-8-methyl-2,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-3-methoxy-phenyl]-1-(3-fluoranylpropyl)azetidin-3-amine | 著者 | Breed, J. | 登録日 | 2020-07-07 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist. J.Med.Chem., 63, 2020
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3NMJ
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![BU of 3nmj by Molmil](/molmil-images/mine/3nmj) | Crystal structure of a nickel mediated dimer for the phenanthroline-modified cytochrome cb562 variant, MBP-Phen2 | 分子名称: | N-1,10-phenanthrolin-5-ylacetamide, NICKEL (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Radford, R.J, Tezcan, F.A. | 登録日 | 2010-06-22 | 公開日 | 2010-11-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Porous protein frameworks with unsaturated metal centers in sterically encumbered coordination sites. Chem.Commun.(Camb.), 47, 2011
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3NMK
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![BU of 3nmk by Molmil](/molmil-images/mine/3nmk) | Crystal structure of a zinc mediated dimer for the phenanthroline-modified cytochrome cb562 variant, MBP-Phen2 | 分子名称: | N-1,10-phenanthrolin-5-ylacetamide, PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562, ... | 著者 | Radford, R.J, Tezcan, F.A. | 登録日 | 2010-06-22 | 公開日 | 2010-11-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Porous protein frameworks with unsaturated metal centers in sterically encumbered coordination sites. Chem.Commun.(Camb.), 47, 2011
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3NMI
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![BU of 3nmi by Molmil](/molmil-images/mine/3nmi) | Crystal structure of the phenanthroline-modified cytochrome cb562 variant, MBP-Phen2 | 分子名称: | ACETATE ION, N-1,10-phenanthrolin-5-ylacetamide, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Radford, R.J, Tezcan, F.A. | 登録日 | 2010-06-22 | 公開日 | 2010-11-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Porous protein frameworks with unsaturated metal centers in sterically encumbered coordination sites. Chem.Commun.(Camb.), 47, 2011
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8OYP
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![BU of 8oyp by Molmil](/molmil-images/mine/8oyp) | Crystal structure of Ubiquitin specific protease 11 (USP11) in complex with a substrate mimetic | 分子名称: | CADMIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Maurer, S.K, Caulton, S.G, Ward, S.J, Emsley, J, Dreveny, I. | 登録日 | 2023-05-05 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity. J.Biol.Chem., 299, 2023
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7PPX
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![BU of 7ppx by Molmil](/molmil-images/mine/7ppx) | ATAD2 in complex with FragLite3 | 分子名称: | 1,2-ETHANEDIOL, 4-bromanyl-1,2-oxazole, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Wood, D.J, Ng, Y.M, Heath, R, Endicott, J.A, Noble, M.E.M. | 登録日 | 2021-09-15 | 公開日 | 2022-09-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QU7
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![BU of 7qu7 by Molmil](/molmil-images/mine/7qu7) | ATAD2 in complex with FragLite16 | 分子名称: | 1,2-ETHANEDIOL, 4-bromanyl-1,8-naphthyridine, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-17 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QWO
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![BU of 7qwo by Molmil](/molmil-images/mine/7qwo) | ATAD2 in complex with FragLite6 | 分子名称: | 1,2-ETHANEDIOL, 4-bromanyl-1~{H}-pyridin-2-one, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-25 | 公開日 | 2022-11-23 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QX1
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![BU of 7qx1 by Molmil](/molmil-images/mine/7qx1) | ATAD2 in complex with FragLite7 | 分子名称: | 1,2-ETHANEDIOL, 4-iodanyl-3~{H}-pyridin-2-one, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-26 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QXT
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![BU of 7qxt by Molmil](/molmil-images/mine/7qxt) | ATAD2 in complex with FragLite10 | 分子名称: | 1,2-ETHANEDIOL, 6-bromo-1,3-dihydro-2H-indol-2-one, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-27 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QYL
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![BU of 7qyl by Molmil](/molmil-images/mine/7qyl) | ATAD2 in complex with FragLite23 | 分子名称: | 1,2-ETHANEDIOL, 2-(4-bromo-1H-pyrazol-1-yl)ethan-1-ol, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-28 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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7QUK
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![BU of 7quk by Molmil](/molmil-images/mine/7quk) | ATAD2 in complex with FragLite1 | 分子名称: | 1,2-ETHANEDIOL, 4-bromo-1H-pyrazole, ATPase family AAA domain-containing protein 2, ... | 著者 | Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M. | 登録日 | 2022-01-18 | 公開日 | 2022-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions. J.Med.Chem., 65, 2022
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