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5FQT

Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 4.

Summary for 5FQT
Entry DOI10.2210/pdb5fqt/pdb
Related5FQP 5FQR 5FQS 5FQV
DescriptorESTROGEN RECEPTOR ALPHA, (E)-3-[4-(6-hydroxy-2-isobutyl-5-methyl-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid (3 entities in total)
Functional Keywordssignaling protein, breast cancer, estrogen receptor downregulator, fulvestrant, thiq, nuclear hormone receptor
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight28623.58
Authors
Scott, J.S.,Bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. (deposition date: 2015-12-14, release date: 2016-02-10, Last modification date: 2018-09-19)
Primary citationScott, J.S.,Bailey, A.,Davies, R.D.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D.
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
Acs Med.Chem.Lett., 7:94-, 2016
Cited by
PubMed: 26819673
DOI: 10.1021/ACSMEDCHEMLETT.5B00413
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.99 Å)
Structure validation

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