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6RPX

Cytokine receptor-like factor 3 C-terminus residues 174-442: native

Summary for 6RPX
Entry DOI10.2210/pdb6rpx/pdb
DescriptorCytokine receptor-like factor 3 (2 entities in total)
Functional Keywordsplatelet development, fibronectin domain, spry domain, blood clotting
Biological sourceMus musculus (house mouse)
Total number of polymer chains1
Total formula weight30057.35
Authors
Mifsud, R.W.,Yan, Y.,Bennett, C.,Read, R.J. (deposition date: 2019-05-15, release date: 2020-03-25, Last modification date: 2022-10-05)
Primary citationBennett, C.,Lawrence, M.,Guerrero, J.A.,Stritt, S.,Waller, A.K.,Yan, Y.,Mifsud, R.W.,Ballester-Beltran, J.,Baig, A.,Mueller, A.,Mayer, L.,Warland, J.,Penkett, C.J.,Akbari, P.,Moreau, T.,Evans, A.L.,Mookerjee, S.,Hoffman, G.J.,Saeb-Parsy, K.,Adams, D.J.,Couzens, A.L.,Bender, M.,Erber, W.N.,Nieswandt, B.,Read, R.J.,Ghevaert, C.
CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.
Blood, 139:2227-2239, 2022
Cited by
PubMed: 35051265
DOI: 10.1182/blood.2021013113
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.61 Å)
Structure validation

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