1LSF
 
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1LSC
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1LSA
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8E23
 | | Human DNA polymerase theta in complex with allosteric inhibitor | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ... | | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | | 登録日 | 2022-08-13 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
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8E24
 | | Human DNA polymerase theta in complex with allosteric inhibitor | | 分子名称: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ... | | 著者 | Mader, P, Pau, V.P.T, Sicheri, F. | | 登録日 | 2022-08-13 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
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7LVC
 | | E. coli DHFR by Native Mn,P,S-SAD at Room Temperature | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Greisman, J.B, Dalton, K.M, Hekstra, D.R. | | 登録日 | 2021-02-24 | | 公開日 | 2021-03-17 | | 最終更新日 | 2022-08-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Native SAD phasing at room temperature.
Acta Crystallogr D Struct Biol, 78, 2022
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4K25
 | | Crystal Structure of yeast Qri7 homodimer | | 分子名称: | CALCIUM ION, Probable tRNA threonylcarbamoyladenosine biosynthesis protein QRI7, mitochondrial, ... | | 著者 | Neculai, D, Wan, L, Mao, D.Y, Sicheri, F. | | 登録日 | 2013-04-08 | | 公開日 | 2013-05-08 | | 最終更新日 | 2013-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Res., 41, 2013
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4KC9
 | | Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism | | 分子名称: | E3 ubiquitin-protein ligase ARIH1, ZINC ION | | 著者 | Duda, D.M, Olszewski, J.L, Schulman, B.A. | | 登録日 | 2013-04-24 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.603 Å) | | 主引用文献 | Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism.
Structure, 21, 2013
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6NDU
 | | Structure of human PACRG-MEIG1 complex | | 分子名称: | CHLORIDE ION, Meiosis expressed gene 1 protein homolog, PHOSPHATE ION, ... | | 著者 | Khan, N, Croteau, N, Pelletier, D, Veyron, S, Trempe, J.F. | | 登録日 | 2018-12-14 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of human PACRG in complex with MEIG1
Biorxiv, 2019
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3KN6
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3KN5
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6DRM
 | | OTU domain of Fam105A | | 分子名称: | Inactive ubiquitin thioesterase FAM105A | | 著者 | Ceccarelli, D.F, Sicheri, F, Cordes, S. | | 登録日 | 2018-06-12 | | 公開日 | 2019-05-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.
Structure, 27, 2019
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2K8Y
 | | Solution NMR Structure of Cgi121 from Methanococcus jannaschii. Northeast Structural Genomics Consortium Target MJ0187 | | 分子名称: | Uncharacterized protein MJ0187 | | 著者 | Rumpel, S, Fares, C, Neculai, D, Arrowsmith, C, Montelione, G.T, Sicheri, F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2008-09-25 | | 公開日 | 2008-11-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
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6UCC
 | | Structure of human PACRG-MEIG1 complex (limited proteolysis) | | 分子名称: | DI(HYDROXYETHYL)ETHER, Meiosis expressed gene 1 protein homolog, PHOSPHATE ION, ... | | 著者 | Khan, N, Croteau, N, Pelletier, D, Veyron, S, Trempe, J.F. | | 登録日 | 2019-09-16 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of human PACRG in complex with MEIG1
Biorxiv, 2019
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2MT5
 | | Isolated Ring domain | | 分子名称: | Anaphase-promoting complex subunit 11, ZINC ION | | 著者 | Brown, N.G, Watson, E.R, Weissman, F, Royappa, G, Schulman, B, Jarvis, M, Vanderlinden, R, Frye, J.J, Qiao, R, Petzold, G, Peters, J, Stark, H. | | 登録日 | 2014-08-13 | | 公開日 | 2014-10-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly.
Mol.Cell, 56, 2014
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7RIN
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7RMA
 | | Structure of the fourth UIM (Ubiquitin Interacting Motif) of ANKRD13D in complex with a high affinity UbV (Ubiquitin Variant) | | 分子名称: | Ankyrin repeat domain-containing protein 13D, SODIUM ION, SULFATE ION, ... | | 著者 | Singer, A.U, Manczyk, N, Veggiani, G, Sicheri, F, Sidhu, S.S. | | 登録日 | 2021-07-27 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs.
Acs Chem.Biol., 17, 2022
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4LCD
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8BW9
 | | Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP | | 分子名称: | Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ... | | 著者 | Maisonneuve, P, Fronzes, R, Sicheri, F. | | 登録日 | 2022-12-06 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
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3BS7
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8T6I
 | | Structure of VHH-Fab complex with engineered Crystal Kappa region | | 分子名称: | Fab heavy chain, Fab light chain, GLYCEROL, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-16 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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8T8I
 | | Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-22 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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8T9Y
 | | Structure of VHH-Fab complex with engineered Elbow FNQIKG and Crystal Kappa regions | | 分子名称: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-26 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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6NEP
 | | Structure of human PACRG-MEIG1 complex | | 分子名称: | CHLORIDE ION, Meiosis expressed gene 1 protein homolog, PHOSPHATE ION, ... | | 著者 | Khan, N, Croteau, N, Pelletier, D, Veyron, S, Trempe, J.F. | | 登録日 | 2018-12-18 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.097625 Å) | | 主引用文献 | Crystal structure of human PACRG in complex with MEIG1
Biorxiv, 2019
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5IBK
 | | Skp1-F-box in complex with a ubiquitin variant | | 分子名称: | F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 | | 著者 | Orlicky, S, Sicheri, F. | | 登録日 | 2016-02-22 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proc.Natl.Acad.Sci.USA, 113, 2016
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