7SN6
| U2AF65 UHM BOUND TO SF3B155 ULM5 | 分子名称: | ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit | 著者 | Loerch, S, Jenkins, J.L, Kielkopf, C.L. | 登録日 | 2021-10-27 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. J.Biol.Chem., 298, 2022
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7SLH
| Engineered sperm whale myoglobin-based carbene transferase MbBTIC-C3 | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Jenkins, J.L, Vargas, D, Ren, X, Fasan, R. | 登録日 | 2021-10-24 | 公開日 | 2023-05-03 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nat.Chem., 16, 2024
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7SLI
| Engineered sperm whale myoglobin-based carbene transferase MbBTIC-C2 | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Jenkins, J.L, Vargas, D, Ren, X, Fasan, R. | 登録日 | 2021-10-24 | 公開日 | 2023-05-03 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nat.Chem., 16, 2024
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2RBF
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8FLK
| Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 | 分子名称: | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP | 著者 | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
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8FLM
| Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | 分子名称: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | 著者 | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
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6PJV
| Structure of Human Sonic Hedgehog in complex with Zinc and Magnesium | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Bonn-Breach, R.B, Jenkins, J.L, Wedekind, J.E. | 登録日 | 2019-06-28 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design. Acta Crystallogr D Struct Biol, 75, 2019
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4CI2
| Structure of the DDB1-CRBN E3 ubiquitin ligase bound to lenalidomide | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Lenalidomide, ... | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | 登録日 | 2013-12-05 | 公開日 | 2014-07-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI1
| Structure of the DDB1-CRBN E3 ubiquitin ligase bound to thalidomide | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Thalidomide, ... | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | 登録日 | 2013-12-05 | 公開日 | 2014-07-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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4CI3
| Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide | 分子名称: | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ... | 著者 | Fischer, E.S, Boehm, K, Thoma, N.H. | 登録日 | 2013-12-05 | 公開日 | 2014-07-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512, 2014
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