1Y4S
 
 | | Conformation rearrangement of heat shock protein 90 upon ADP binding | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperone protein htpG, MAGNESIUM ION | | 著者 | Huai, Q, Wang, H, Liu, Y, Kim, H, Toft, D, Ke, H. | | 登録日 | 2004-12-01 | | 公開日 | 2005-04-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Structure, 13, 2005
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8DZT
 | | Crystal structure of human Sar1aH79G mutant | | 分子名称: | CALCIUM ION, GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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8E0A
 | | Crystal structure of human Sar1b | | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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8E0D
 | | Crystal structure of human Sar1bE140D | | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5',3'-TETRAPHOSPHATE | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.981 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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8E0H
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8DZO
 | | Crystal structure of human Sar1T39N mutant | | 分子名称: | CALCIUM ION, GTP-binding protein SAR1a, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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1Y4U
 | | Conformation rearrangement of heat shock protein 90 upon ADP binding | | 分子名称: | Chaperone protein htpG | | 著者 | Huai, Q, Wang, H, Liu, Y, Kim, H, Toft, D, Ke, H. | | 登録日 | 2004-12-01 | | 公開日 | 2005-04-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Structure, 13, 2005
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8E0B
 | | Crystal structure of human Sar1bT39N | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, Sar1bT39N | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.212 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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8E0C
 | | Crystal structure of human Sar1bH79G | | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.993 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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8DZN
 | | Crystal structure of human Sar1a in complex with GDP | | 分子名称: | GTP-binding protein SAR1a, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION | | 著者 | Huang, Q. | | 登録日 | 2022-08-08 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.107 Å) | | 主引用文献 | The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Proteins, 91, 2023
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8DZM
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8ETD
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1ZKN
 | | Structure of PDE4D2-IBMX | | 分子名称: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, ZINC ION, ... | | 著者 | Huai, Q, Liu, Y, Francis, S.H, Corbin, J.D, Ke, H. | | 登録日 | 2005-05-03 | | 公開日 | 2005-05-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-Methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
J.Biol.Chem., 279, 2004
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5T8N
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5T8L
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5D3O
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8WCO
 | | (S)-citramalyl-CoA lyase | | 分子名称: | ACETYL COENZYME *A, Probable acyl-CoA lyase beta chain | | 著者 | Huang, Q, Bao, R. | | 登録日 | 2023-09-13 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa.
Structure, 32, 2024
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2HD1
 | | Crystal structure of PDE9 in complex with IBMX | | 分子名称: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ... | | 著者 | Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H. | | 登録日 | 2006-06-19 | | 公開日 | 2006-06-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding
Proc.Natl.Acad.Sci.USA, 101, 2004
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5HL1
 | | Crystal structure of glutaminase C in complex with inhibitor CB-839 | | 分子名称: | 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial | | 著者 | Huang, Q, Cerione, R.A. | | 登録日 | 2016-01-14 | | 公開日 | 2016-08-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C
To Be Published
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8KHL
 | | (S)-citramalyl-CoA lyase | | 分子名称: | COENZYME A, Probable acyl-CoA lyase beta chain | | 著者 | Huang, Q, Bao, R. | | 登録日 | 2023-08-22 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa.
Structure, 32, 2024
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8KHG
 | | Itaconyl-CoA hydratase PaIch | | 分子名称: | CITRIC ACID, Itaconyl-CoA hydratase | | 著者 | Huang, Q, Bao, R. | | 登録日 | 2023-08-21 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and functional characterization of itaconyl-CoA hydratase and citramalyl-CoA lyase involved in itaconate metabolism of Pseudomonas aeruginosa.
Structure, 32, 2024
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5WJ6
 | | Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004) | | 分子名称: | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | | 著者 | Huang, Q, Cerione, R.A. | | 登録日 | 2017-07-21 | | 公開日 | 2018-01-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.445 Å) | | 主引用文献 | Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
J. Biol. Chem., 293, 2018
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3LYO
 | | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 95% ACETONITRILE-WATER | | 分子名称: | ACETONITRILE, LYSOZYME | | 著者 | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | | 登録日 | 1998-03-11 | | 公開日 | 1998-05-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture.
Biochim.Biophys.Acta, 1384, 1998
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2LYO
 | | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 90% ACETONITRILE-WATER | | 分子名称: | ACETONITRILE, LYSOZYME | | 著者 | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | | 登録日 | 1998-03-06 | | 公開日 | 1998-05-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture.
Biochim.Biophys.Acta, 1384, 1998
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2FD6
 | | Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A | | 分子名称: | 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... | | 著者 | Huang, M, Huai, Q, Li, Y. | | 登録日 | 2005-12-13 | | 公開日 | 2006-02-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311, 2006
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