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5L9T
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BU of 5l9t by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
分子名称: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
著者Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
登録日2016-06-11
公開日2016-10-26
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (6.4 Å)
主引用文献Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5JG6
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BU of 5jg6 by Molmil
APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C
分子名称: Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
著者Brown, N.G, Zhang, W, Yu, S, Miller, D.J, Sidhu, S.S, Schulman, B.A.
登録日2016-04-19
公開日2016-06-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.0013 Å)
主引用文献Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
2MAH
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BU of 2mah by Molmil
Solution structure of Smoothened
分子名称: Protein smoothened
著者Rana, R, Lee, H, Zheng, J.J.
登録日2013-07-09
公開日2014-03-05
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.
Nat Commun, 4, 2013
2M03
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BU of 2m03 by Molmil
Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains
分子名称: Bcl-2-like protein 1
著者Viacava Follis, A, Royappa, G, Kriwacki, R.W.
登録日2012-10-19
公開日2013-01-30
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
2MT5
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BU of 2mt5 by Molmil
Isolated Ring domain
分子名称: Anaphase-promoting complex subunit 11, ZINC ION
著者Brown, N.G, Watson, E.R, Weissman, F, Royappa, G, Schulman, B, Jarvis, M, Vanderlinden, R, Frye, J.J, Qiao, R, Petzold, G, Peters, J, Stark, H.
登録日2014-08-13
公開日2014-10-29
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly.
Mol.Cell, 56, 2014
2M04
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BU of 2m04 by Molmil
Solution structure of BCL-xL in complex with PUMA BH3 peptide
分子名称: Bcl-2-binding component 3, Bcl-2-like protein 1
著者Viacava Follis, A, Royappa, G, Kriwacki, R.W.
登録日2012-10-19
公開日2013-01-30
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
2M6N
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BU of 2m6n by Molmil
3D solution structure of EMI1 (Early Mitotic Inhibitor 1)
分子名称: F-box only protein 5, ZINC ION
著者Frye, J.J, Brown, N.G, Petzold, G, Watson, E.R, Royappa, G.R, Nourse, A, Jarvis, M, Kriwacki, R.W, Peters, J, Stark, H, Schulman, B.A.
登録日2013-04-06
公開日2013-05-29
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.
Nat.Struct.Mol.Biol., 20, 2013
2ME8
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BU of 2me8 by Molmil
Solution Structure of BCL-xL in its p53-bound conformation determined with selective isotope labelling of I,L,V sidechains
分子名称: Bcl-2-like protein 1
著者Viacava Follis, A, Grace, C.R, Kriwacki, R.W.
登録日2013-09-25
公開日2014-04-30
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2ME9
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BU of 2me9 by Molmil
Solution structure of BCL-xL containing the alpha1-alpha2 disordered loop determined with selective isotope labelling of I,L,V sidechains
分子名称: Bcl-2-like protein 1
著者Viacava Follis, A, Grace, C.R, Kriwacki, R.W.
登録日2013-09-25
公開日2014-04-30
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2MEJ
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BU of 2mej by Molmil
Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints
分子名称: Bcl-2-like protein 1, Cellular tumor antigen p53, ZINC ION
著者Viacava Follis, A, Grace, C.R, Kriwacki, R.W.
登録日2013-09-25
公開日2014-04-30
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
6NXL
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BU of 6nxl by Molmil
Ubiquitin binding variants
分子名称: Polyubiquitin-B
著者Miller, D.J, Watson, E.R.
登録日2019-02-08
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
6NXK
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BU of 6nxk by Molmil
Ubiquitin binding variants
分子名称: Anaphase-promoting complex subunit 2, Polyubiquitin-C
著者Miller, D.J, Watson, E.R.
登録日2019-02-08
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OJJ
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BU of 6ojj by Molmil
Structure of ScAtg3 with truncations in N-terminal and flexible region (FR)
分子名称: Autophagy-related protein 3,Autophagy-related protein 3, GLYCEROL
著者Zheng, Y, Qiu, Y, Schulman, B.A.
登録日2019-04-11
公開日2019-08-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade.
Nat Commun, 10, 2019
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件を2024-08-07に公開中

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