6TZO
 
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | 2'-DEOXYGUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-12 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6MGN
 | | mouse Id1 (51-104) - human hE47 (348-399) complex | | 分子名称: | DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha | | 著者 | Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. | | 登録日 | 2018-09-14 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.
Cell Rep, 29, 2019
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6MGM
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6C34
 | | Mycobacterium smegmatis DNA flap endonuclease mutant D125N | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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6C36
 | | Mycobacterium smegmatis flap endonuclease mutant D208N | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION, PHOSPHATE ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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6C33
 | | Mycobacterium smegmatis DNA flap endonuclease | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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6C35
 | | Mycobacterium smegmatis flap endonuclease mutant D148N | | 分子名称: | 5'-3' exonuclease, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Carl, A, Uson, M.L. | | 登録日 | 2018-01-09 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Nucleic Acids Res., 46, 2018
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4JZC
 | | Angiopoietin-2 fibrinogen domain TAG mutant | | 分子名称: | Angiopoietin-2 | | 著者 | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | | 登録日 | 2013-04-02 | | 公開日 | 2013-05-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for angiopoietin-1-mediated signaling initiation.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4K0V
 | | Structural basis for angiopoietin-1 mediated signaling initiation | | 分子名称: | Angiopoietin-1, TEK tyrosine kinase variant | | 著者 | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | | 登録日 | 2013-04-04 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (4.51 Å) | | 主引用文献 | Structural basis for angiopoietin-1-mediated signaling initiation.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4JYO
 | | Structural basis for angiopoietin-1 mediated signaling initiation | | 分子名称: | Angiopoietin-1, CALCIUM ION | | 著者 | Yu, X, Seegar, T.C.M, Dalton, A.C, Tzvetkova-Robev, D, Goldgur, Y, Nikolov, D.B, Barton, W.A. | | 登録日 | 2013-03-31 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for angiopoietin-1-mediated signaling initiation.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5COV
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5CMA
 | | Anti-B7-H3 monoclonal antibody ch8H9 Fab fragment | | 分子名称: | Antibody ch8H9 Fab heavy chain, Antibody ch8H9 Fab light chain | | 著者 | Ahmed, M, Goldgur, Y, Cheng, M, Cheung, N.K. | | 登録日 | 2015-07-16 | | 公開日 | 2015-10-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3.
J.Biol.Chem., 290, 2015
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5COU
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5COT
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6N0T
 | | tRNA ligase | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, SULFATE ION, ... | | 著者 | Banerjee, A, Goldgur, Y, Shuman, S. | | 登録日 | 2018-11-07 | | 公開日 | 2019-01-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.511 Å) | | 主引用文献 | Structure and two-metal mechanism of fungal tRNA ligase.
Nucleic Acids Res., 47, 2019
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6N0V
 | | tRNA ligase | | 分子名称: | MANGANESE (II) ION, tRNA ligase | | 著者 | Banerjee, A, Goldgur, Y, Shuman, S. | | 登録日 | 2018-11-07 | | 公開日 | 2019-01-09 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | Structure and two-metal mechanism of fungal tRNA ligase.
Nucleic Acids Res., 47, 2019
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6O19
 | | Crystal Structure of Pho7 complex with pho1 promoter site 2 | | 分子名称: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*AP*TP*TP*TP*CP*CP*GP*AP*AP*TP*AP*AP*T)-3'), DNA (5'-D(*TP*TP*AP*TP*TP*CP*GP*GP*AP*AP*AP*TP*TP*AP*AP*AP*AP*AP*CP*A)-3'), Transcription factor Pho7, ... | | 著者 | Garg, A, Goldgur, Y, Shuman, S. | | 登録日 | 2019-02-18 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.596 Å) | | 主引用文献 | Structure of Fission Yeast Transcription Factor Pho7 Bound topho1Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis.
Mol.Cell.Biol., 39, 2019
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6NHZ
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6NHX
 | | mycobacterial DNA ligase D complexed with ATP and MES | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent DNA ligase | | 著者 | Shuman, S, Unciuleac, M, Goldgur, Y. | | 登録日 | 2018-12-24 | | 公開日 | 2019-02-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates.
J. Biol. Chem., 294, 2019
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6TZM
 | | Crystal Structure of Fungal RNA Kinase | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, tRNA ligase | | 著者 | Shuman, S, Goldgur, Y, Banerjee, A. | | 登録日 | 2019-08-12 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.714 Å) | | 主引用文献 | Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor.
Nucleic Acids Res., 47, 2019
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6VDD
 | | POL domain of Pol1 from M. smegmatis complex with DNA primer-template and dNTP | | 分子名称: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A*(DCT))-3'), DNA (5'-D(P*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ... | | 著者 | Shuman, S, Goldgur, Y, Ghosh, S. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.
Nucleic Acids Res., 48, 2020
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6VDC
 | | POL domain of Pol1 from M. smegmatis | | 分子名称: | DNA polymerase I, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Ghosh, S. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.
Nucleic Acids Res., 48, 2020
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6VDE
 | | Full-length M. smegmatis Pol1 | | 分子名称: | DNA polymerase I, MANGANESE (II) ION | | 著者 | Shuman, S, Goldgur, Y, Ghosh, S. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.713 Å) | | 主引用文献 | Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme.
Nucleic Acids Res., 48, 2020
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6VT4
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6VTE
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