8UET
 
 | | In-situ complex I, Deactive class02 | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-02 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UGF
 | | In-situ complex III, state III | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | | 著者 | Zheng, W, Zhang, K, Zhu, J. | | 登録日 | 2023-10-05 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UEO
 | | In-situ complex I (Active-Apo) | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-02 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UGG
 | | In-situ complex III, state IV | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | | 著者 | Zheng, W, Zhang, K, Zhu, J. | | 登録日 | 2023-10-05 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UEW
 | | In-situ complex I, Deactive class05 | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-02 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UGP
 | | In-situ structure of typeA supercomplex in respiratory chain ( local refined map focused on CI iron-sulfur cluster regions ) | | 分子名称: | IRON/SULFUR CLUSTER, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6, ... | | 著者 | Zheng, W, Zhang, K, Zhu, J. | | 登録日 | 2023-10-05 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UES
 | | In-situ complex I, Deactive class01 | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-02 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UGJ
 | | In-situ structure of typeB supercomplex in respiratory chain (composite) | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | | 著者 | Zheng, W, Zhang, K, Zhu, J. | | 登録日 | 2023-10-05 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UER
 | | In-situ complex I with Q10 (State-gamma) | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-02 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UGK
 | | High resolution in-situ structure of complex III in respiratory supercomplex (composite) | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-05 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.1 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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8UEU
 | | In-situ complex I, Deactive class03 | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | 著者 | Zheng, W, Zhu, J, Zhang, K. | | 登録日 | 2023-10-02 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | High-resolution in situ structures of mammalian respiratory supercomplexes.
Nature, 631, 2024
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7K58
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7K5B
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7KEK
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5KWW
 | | Crystal Structure of Inhibitor JNJ-53718678 In Complex with Prefusion RSV F Glycoprotein | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[5-chloranyl-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-[2,2,2-tris(fluoranyl)ethyl]imidazo[4,5-c]pyridin-2-one, ... | | 著者 | McLellan, J.S, Battles, M.B, Arnoult, E, Roymans, D, Langedijk, J.P. | | 登録日 | 2016-07-19 | | 公開日 | 2017-08-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.
Nat Commun, 8, 2017
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8IQ8
 | | Crystal structure of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (DHPAO) from Acinetobacter baumannii | | 分子名称: | 3,4-dihydroxyphenylacetate 2,3-dioxygenase, SODIUM ION | | 著者 | Chitnumsub, P, Maenpuen, S. | | 登録日 | 2023-03-16 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure and biochemical characterization of an extradiol 3,4-dihydroxyphenylacetate 2,3-dioxygenase from Acinetobacter baumannii.
Arch.Biochem.Biophys., 747, 2023
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4R8M
 | | Human SIRT2 crystal structure in complex with BHJH-TM1 | | 分子名称: | BHJH-TM1 peptide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | | 著者 | Teng, Y.B, Hao, Q, Lin, H.N, Jing, H. | | 登録日 | 2014-09-02 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
Sci Rep, 5, 2015
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2IGK
 | | Crystal structure of recombinant pyranose 2-oxidase | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, Pyranose oxidase | | 著者 | Divne, C. | | 登録日 | 2006-09-22 | | 公開日 | 2006-10-10 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for substrate binding and regioselective oxidation of monosaccharides at c3 by pyranose 2-oxidase.
J.Biol.Chem., 281, 2006
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2IGO
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4TN4
 | | Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | | 分子名称: | (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Witschel, M.C. | | 登録日 | 2014-06-03 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities.
J.Med.Chem., 58, 2015
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4TMR
 | | Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate . | | 分子名称: | CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], Serine hydroxymethyltransferase, ... | | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Witschel, M.C. | | 登録日 | 2014-06-02 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities.
J.Med.Chem., 58, 2015
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3N2S
 | | Structure of NfrA1 nitroreductase from B. subtilis | | 分子名称: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, NADPH-dependent nitro/flavin reductase | | 著者 | Morera, S, Gueguen-Chaignon, V, Meyer, P, Cortial, S, Ouazzani, J. | | 登録日 | 2010-05-19 | | 公開日 | 2010-09-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role.
Febs Lett., 584, 2010
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8SMV
 | | GPR161 Gs heterotrimer | | 分子名称: | CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hoppe, N, Manglik, A, Harrison, S. | | 登録日 | 2023-04-26 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Biorxiv, 2023
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5XMR
 | | Plasmodium vivax SHMT(C346A) bound with PLP-glycine and GS395 | | 分子名称: | (4~{S})-6-azanyl-3-methyl-4-[3-[4-(phenylmethyl)sulfonylphenyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2 ,3-c]pyrazole-5-carbonitrile, CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... | | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Schwertz, G, Diederich, F. | | 登録日 | 2017-05-16 | | 公開日 | 2017-11-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs
Chemistry, 23, 2017
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5XMP
 | | Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF057 | | 分子名称: | 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]-~{N}-methyl-~{N}-[2,2,2-tris(fluoranyl)ethyl]benzenesulfonamide, CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... | | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Schwertz, G, Diederich, F. | | 登録日 | 2017-05-16 | | 公開日 | 2017-11-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs
Chemistry, 23, 2017
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