5XMP
Plasmodium vivax SHMT(C346A) bound with PLP-glycine and MF057
Summary for 5XMP
Entry DOI | 10.2210/pdb5xmp/pdb |
Descriptor | Serine hydroxymethyltransferase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]-~{N}-methyl-~{N}-[2,2,2-tris(fluoranyl)ethyl]benzenesulfonamide, ... (5 entities in total) |
Functional Keywords | alpha and beta protein, methyltransferase activity, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Plasmodium vivax |
Total number of polymer chains | 3 |
Total formula weight | 150481.55 |
Authors | Chitnumsub, P.,Jaruwat, A.,Leartsakulpanich, U.,Schwertz, G.,Diederich, F. (deposition date: 2017-05-16, release date: 2017-11-29, Last modification date: 2023-11-22) |
Primary citation | Schwertz, G.,Frei, M.S.,Witschel, M.C.,Rottmann, M.,Leartsakulpanich, U.,Chitnumsub, P.,Jaruwat, A.,Ittarat, W.,Schafer, A.,Aponte, R.A.,Trapp, N.,Mark, K.,Chaiyen, P.,Diederich, F. Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs Chemistry, 23:14345-14357, 2017 Cited by PubMed: 28967982DOI: 10.1002/chem.201703244 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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