5XU9
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![BU of 5xu9 by Molmil](/molmil-images/mine/5xu9) | Crystal Structure of Transketolase in complex with TPP intermediate IX and gauche form erythrose-4-phosphate from Pichia Stipitis | 分子名称: | 2-[(2E)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[1,2-bis(oxidanyl)ethylidene]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Li, T.L, Hsu, N.S, Wang, Y.L. | 登録日 | 2017-06-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.166 Å) | 主引用文献 | Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. Chembiochem, 19, 2018
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5XQK
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![BU of 5xqk by Molmil](/molmil-images/mine/5xqk) | Crystal Structure of Transketolase in complex with xylulose-5-phosphate from Pichia Stipitis | 分子名称: | 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thia zol-3-ium-2-yl}-5-O-phosphono-D-xylitol, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Li, T.L, Hsu, N.S, Wang, Y.L. | 登録日 | 2017-06-07 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. Chembiochem, 19, 2018
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5XQA
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![BU of 5xqa by Molmil](/molmil-images/mine/5xqa) | Crystal Structure of Transketolase in complex with ribose-5-phosphate from Pichia Stipitis | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, THIAMINE DIPHOSPHATE, ... | 著者 | Li, T.L, Hsu, N.S, Wang, Y.L. | 登録日 | 2017-06-06 | 公開日 | 2018-06-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. Chembiochem, 19, 2018
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5XRV
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![BU of 5xrv by Molmil](/molmil-images/mine/5xrv) | Crystal Structure of Transketolase in complex with TPP_V and fructose-6-phosphate from Pichia Stipitis | 分子名称: | 2-[(5S)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methylidene-1,3-thiazolidin-5-yl]ethyl phosphono hydrogen phosphate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Li, T.L, Hsu, N.S, Wang, Y.L. | 登録日 | 2017-06-09 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto-Transferring Reactions. Chembiochem, 19, 2018
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6UEL
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![BU of 6uel by Molmil](/molmil-images/mine/6uel) | CPS1 bound to allosteric inhibitor H3B-193 | 分子名称: | Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ... | 著者 | Larsen, N.A, Nguyen, T.V. | 登録日 | 2019-09-21 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol, 27, 2020
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6W2J
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![BU of 6w2j by Molmil](/molmil-images/mine/6w2j) | CPS1 bound to allosteric inhibitor H3B-374 | 分子名称: | (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ... | 著者 | Larsen, N.A, Nguyen, T.V. | 登録日 | 2020-03-05 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1. Acs Med.Chem.Lett., 11, 2020
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2MVJ
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![BU of 2mvj by Molmil](/molmil-images/mine/2mvj) | |
2MVH
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![BU of 2mvh by Molmil](/molmil-images/mine/2mvh) | |
4HYS
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![BU of 4hys by Molmil](/molmil-images/mine/4hys) | |
4HYU
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![BU of 4hyu by Molmil](/molmil-images/mine/4hyu) | |
4OP3
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![BU of 4op3 by Molmil](/molmil-images/mine/4op3) | Human GKRP bound to AMG-5112 and Sorbitol-6-phosphate | 分子名称: | (2S)-2-{6'-[(6-aminopyridin-3-yl)sulfonyl]-2'-(phenylamino)-2,3'-bipyridin-5-yl}-1,1,1-trifluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-02-04 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis. J.Med.Chem., 58, 2015
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4OP1
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![BU of 4op1 by Molmil](/molmil-images/mine/4op1) | GKRP bound to AMG0556 and Sorbitol-6-Phosphate | 分子名称: | (2S)-2-(6-{5-[(6-aminopyridin-3-yl)sulfonyl]thiophen-2-yl}-5-chloropyridin-3-yl)-1,1,1-trifluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-02-04 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis. J.Med.Chem., 58, 2015
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4OHM
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![BU of 4ohm by Molmil](/molmil-images/mine/4ohm) | Human GKRP bound to AMG-0771 and sorbitol-6-phosphate | 分子名称: | (2S)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-3,3,3-trifluoropropane-1,2-diol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-01-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57, 2014
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4OP2
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![BU of 4op2 by Molmil](/molmil-images/mine/4op2) | GKRP bound to AMG-0471 and Sorbitol-6-Phosphate | 分子名称: | (2S)-2-{4'-[(6-aminopyridin-3-yl)sulfonyl]biphenyl-4-yl}-1,1,1-trifluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-02-04 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis. J.Med.Chem., 58, 2015
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4OHO
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![BU of 4oho by Molmil](/molmil-images/mine/4oho) | Human GKRP bound to AMG-2668 | 分子名称: | 5-{[(3S)-3-(prop-1-yn-1-yl)-4-{4-[S-(trifluoromethyl)sulfonimidoyl]phenyl}piperazin-1-yl]sulfonyl}pyridin-2-amine, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-01-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57, 2014
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4OHK
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![BU of 4ohk by Molmil](/molmil-images/mine/4ohk) | Human GKRP bound to AMG-2526 and S6P | 分子名称: | (2R)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1-trifluorohex-4-yn-2-ol, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-01-17 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57, 2014
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4OHP
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![BU of 4ohp by Molmil](/molmil-images/mine/4ohp) | Human GKRP bound to AMG-3227 and S6P | 分子名称: | 4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]-N-methylbenzenesulfonamide, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... | 著者 | Jordan, S.R, Chmait, S. | 登録日 | 2014-01-17 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57, 2014
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2UVR
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![BU of 2uvr by Molmil](/molmil-images/mine/2uvr) | |
2UVW
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![BU of 2uvw by Molmil](/molmil-images/mine/2uvw) | |
2UVU
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![BU of 2uvu by Molmil](/molmil-images/mine/2uvu) | |
2UVV
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![BU of 2uvv by Molmil](/molmil-images/mine/2uvv) | |
2C22
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![BU of 2c22 by Molmil](/molmil-images/mine/2c22) | Efficient and High Fidelity Incorporation of dCTP Opposite 7,8- Dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA Polymerase Dpo4 | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*C)-3', 5'-D(TP*CP*AP*C 8OGP*GP*AP*AP*TP*CP*CP*TP *TP*CP*CP*CP*CP*C)-3', ... | 著者 | Irimia, A, Loukachevitch, L.V, Egli, M. | 登録日 | 2005-09-26 | 公開日 | 2005-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Efficient and High Fidelity Incorporation of Dctp Opposite 7,8-Dihydro-8-Oxodeoxyguanosine by Sulfolobus Solfataricus DNA Polymerase Dpo4 J.Biol.Chem., 281, 2006
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2C2D
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![BU of 2c2d by Molmil](/molmil-images/mine/2c2d) | Efficient and High Fidelity Incorporation of dCTP Opposite 7,8- Dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA Polymerase Dpo4 | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*C)-3', 5'-D(*TP*CP*AP*C 8OGP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | 著者 | Irimia, A, Loukachevitch, L.V, Egli, M. | 登録日 | 2005-09-27 | 公開日 | 2005-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Efficient and High Fidelity Incorporation of Dctp Opposite 7,8-Dihydro-8-Oxodeoxyguanosine by Sulfolobus Solfataricus DNA Polymerase Dpo4 J.Biol.Chem., 281, 2006
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2C28
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![BU of 2c28 by Molmil](/molmil-images/mine/2c28) | Efficient and High Fidelity Incorporation of dCTP Opposite 7,8- Dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA Polymerase Dpo4 | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*C)-3', 5'-D(TP*CP*AP*C 8OGP*GP*AP*AP*TP*CP*CP*TP *TP*CP*CP*CP*CP*C)-3', ... | 著者 | Irimia, A, Loukachevitch, L.V, Egli, M. | 登録日 | 2005-09-26 | 公開日 | 2005-11-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Efficient and High Fidelity Incorporation of Dctp Opposite 7,8-Dihydro-8-Oxodeoxyguanosine by Sulfolobus Solfataricus DNA Polymerase Dpo4 J.Biol.Chem., 281, 2006
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2BR0
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![BU of 2br0 by Molmil](/molmil-images/mine/2br0) | DNA Adduct Bypass Polymerization by Sulfolobus solfataricus Dpo4. Analysis and Crystal Structures of Multiple Base-Pair Substitution and Frameshift Products with the Adduct 1,N2-Ethenoguanine | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*C)-3', 5'-D(*TP*CP*AP*CP*GNEP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | 著者 | Irimia, A, Loukachevitch, L.V, Egli, M. | 登録日 | 2005-04-28 | 公開日 | 2005-06-23 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | DNA Adduct Bypass Polymerization by Sulfolobus Solfataricus DNA Polymerase Dpo4: Analysis and Crystal Structures of Multiple Base Pair Substitution and Frameshift Products with the Adduct 1,N2-Ethenoguanine. J.Biol.Chem., 280, 2005
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