4OHK

Human GKRP bound to AMG-2526 and S6P

Summary for 4OHK

• Entry DOI: 10.2210/pdb4ohk/pdb
• Related: 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3
• Descriptor: Glucokinase regulatory protein, (2R)-2-{4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]phenyl}-1,1,1-trifluorohex-4-yn-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• Functional Keywords: regulatory protein, binds and inhibits gk (glucokinase), glucokinase, nucleus, carbohydrate binding protein-inhibitor complex, carbohydrate binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q14397
• Total number of polymer chains: 2
• Total formula weight: 145703.50

Authors

Jordan, S.R.,Chmait, S. (deposition date: 2014-01-17, release date: 2014-10-08, Last modification date: 2023-09-20)

• Primary citation: Nishimura, N.,Norman, M.H.,Liu, L.,Yang, K.C.,Ashton, K.S.,Bartberger, M.D.,Chmait, S.,Chen, J.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kunz, R.K.,Pennington, L.D.,Poon, S.F.,Siegmund, A.,Sivits, G.,Lloyd, D.J.,Hale, C.,St Jean, D.J.; Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.; J.Med.Chem., 57:3094-3116, 2014; PubMed: 24611879; DOI: 10.1021/jm5000497

Experimental method

X-RAY DIFFRACTION (2.8 Å)