4OHO

Human GKRP bound to AMG-2668

Summary for 4OHO

Entry DOI	10.2210/pdb4oho/pdb
Related	4OHK 4OHM 4OHP 4OLH 4OP1 4OP2 4OP3
Descriptor	Glucokinase regulatory protein, 5-{[(3S)-3-(prop-1-yn-1-yl)-4-{4-[S-(trifluoromethyl)sulfonimidoyl]phenyl}piperazin-1-yl]sulfonyl}pyridin-2-amine, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
Functional Keywords	sis domain, regulatory protein - binds and inhibits glucokinase, glucokinase, liver, carbohydrate binding protein-inhibitor complex, carbohydrate binding protein/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q14397
Total number of polymer chains	2
Total formula weight	145665.46
Authors	Jordan, S.R.,Chmait, S. (deposition date: 2014-01-17, release date: 2014-07-30, Last modification date: 2023-09-20)
Primary citation	Nishimura, N.,Norman, M.H.,Liu, L.,Yang, K.C.,Ashton, K.S.,Bartberger, M.D.,Chmait, S.,Chen, J.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kunz, R.K.,Pennington, L.D.,Poon, S.F.,Siegmund, A.,Sivits, G.,Lloyd, D.J.,Hale, C.,St Jean, D.J. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57:3094-3116, 2014 Cited by PubMed: 24611879 DOI: 10.1021/jm5000497 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation