8QK5
 
 | | Structure of K. pneumoniae LpxH in complex with EBL-3647 | | 分子名称: | 5-[[3-(aminomethyl)azetidin-1-yl]methyl]-N-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | | 著者 | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8QK9
 | | Structure of E. coli LpxH in complex with JEDI-1444 | | 分子名称: | 2-[methyl(methylsulfonyl)amino]-~{N}-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylphenyl]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | | 著者 | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8QKA
 | | Structure of K. pneumoniae LpxH in complex with JEDI-852 | | 分子名称: | 2-[methyl(methylsulfonyl)amino]-~{N}-(4-piperidin-1-ylsulfonylphenyl)benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | | 著者 | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8QJZ
 | | Crystal structure of E. coli LpxH in complex with lipid X | | 分子名称: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | | 著者 | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Proc.Natl.Acad.Sci.USA, 121, 2024
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6B12
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6AXJ
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6YVC
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6H3N
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5I7J
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5I7K
 | | Crystal Structure of Human SPLUNC1 Dolphin Mutant D1 (G58A, S61A, G62E, G63D, G66D, I67T) | | 分子名称: | BPI fold-containing family A member 1 | | 著者 | Walton, W.G, Redinbo, M.R. | | 登録日 | 2016-02-17 | | 公開日 | 2016-05-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | | 主引用文献 | Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.
Biochemistry, 55, 2016
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5I7L
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4J7T
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | D-gamma-glutamyl-S-(4-phenylbutyl)-L-cysteinylglycine, Leukotriene C4 synthase, NICKEL (II) ION, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-14 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.203 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4J7Y
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | D-gamma-glutamyl-(Z)-N-(carboxymethylidene)-S-[(2R)-2-hydroxy-4-phenylbutyl]-L-cysteinamide, Leukotriene C4 synthase, NICKEL (II) ION, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-14 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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6SSW
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6SSU
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4JRZ
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-03-22 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4JCZ
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-22 | | 公開日 | 2014-01-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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6SSR
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6SSS
 | | Crystal structure of Human Microsomal Glutathione S-Transferase 2 | | 分子名称: | 1-(8Z-hexadecenoyl)-sn-glycerol, GLYCEROL, Microsomal glutathione S-transferase 2, ... | | 著者 | Thulasingam, M, Nji, E, Haeggstrom, J.Z. | | 登録日 | 2019-09-09 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.498 Å) | | 主引用文献 | Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
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4JC7
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | 分子名称: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | 著者 | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | 登録日 | 2013-02-21 | | 公開日 | 2014-01-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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3QMM
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5Y81
 | | NuA4 TEEAA sub-complex | | 分子名称: | Actin, Actin-related protein 4, Chromatin modification-related protein EAF1, ... | | 著者 | Wang, X, Cai, G. | | 登録日 | 2017-08-18 | | 公開日 | 2018-04-18 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex
Nat Commun, 9, 2018
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5YWW
 | | Archael RuvB-like Holiday junction helicase | | 分子名称: | GLYCEROL, Nucleotide binding protein PINc | | 著者 | Zhai, B, Yuan, Z, Han, X, DuPrez, K, Shen, Y, Fan, L. | | 登録日 | 2017-11-30 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction.
Nucleic Acids Res., 46, 2018
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1T2N
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