4PGB
 
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNWPAL | | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | 著者 | Celie, P.H.N, Joosten, R.P, Perrakis, A, Neefjes, J. | | 登録日 | 2014-05-01 | | 公開日 | 2015-01-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGC
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGN(3,5-diiodotyrosine)PAL | | 分子名称: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | 著者 | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | 登録日 | 2014-05-01 | | 公開日 | 2015-01-07 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PG9
 | | MHC Class I in complex with Sendai virus nucleoprotein peptide FAPGNYPAL | | 分子名称: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | 著者 | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | 登録日 | 2014-05-01 | | 公開日 | 2015-01-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGE
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAW | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | 著者 | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | 登録日 | 2014-05-01 | | 公開日 | 2015-01-07 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PGD
 | | MHC Class I in complex with modified Sendai virus nucleoprotein peptide FAPGNYPAF | | 分子名称: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | 著者 | Celie, P, Joosten, R.P, Perrakis, A, Neefjes, J. | | 登録日 | 2014-05-01 | | 公開日 | 2015-01-07 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The first step of peptide selection in antigen presentation by MHC class I molecules.
Proc.Natl.Acad.Sci.USA, 112, 2015
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2KLT
 | | Second Ca2+ binding domain of NCX1.3 | | 分子名称: | Sodium/calcium exchanger 1 | | 著者 | Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W. | | 登録日 | 2009-07-08 | | 公開日 | 2009-08-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
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7A5U
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7A74
 | | Structure of G132N BlaC from Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-27 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics.
Antimicrob.Agents Chemother., 65, 2021
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7A72
 | | Structure of G132S BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam | | 分子名称: | ACETATE ION, Beta-lactamase, GLYCEROL, ... | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-27 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam.
Biochemistry, 60, 2021
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7A5T
 | | Crystal structure of A55E mutant of BlaC from Mycobacterium tuberculosis | | 分子名称: | Beta-lactamase, GLYCEROL, PHOSPHATE ION | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-21 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam.
Biochemistry, 60, 2021
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7A5W
 | | Structure of D172N BlaC from Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-24 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam.
Biochemistry, 60, 2021
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7A71
 | | Structure of G132S BlaC from Mycobacterium tuberculosis | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase, GLYCEROL, ... | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-27 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam.
Biochemistry, 60, 2021
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7A6Z
 | | Structure of P226G BlaC from Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | | 登録日 | 2020-08-27 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Conserved proline residues prevent dimerization and aggregation in the beta-lactamase BlaC.
Protein Sci., 33, 2024
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2KLS
 | | Apo-form of the second Ca2+ binding domain of NCX1.4 | | 分子名称: | Sodium/calcium exchanger 1 | | 著者 | Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W. | | 登録日 | 2009-07-08 | | 公開日 | 2009-08-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5M0M
 | | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | | 登録日 | 2016-10-05 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.
J. Med. Chem., 60, 2017
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5M0S
 | | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | | 分子名称: | CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, ... | | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | | 登録日 | 2016-10-05 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.
J. Med. Chem., 60, 2017
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5LJJ
 | | Crystal structure of human Mps1 (TTK) in complex with Reversine | | 分子名称: | 1,2-ETHANEDIOL, Dual specificity protein kinase TTK, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine | | 著者 | Hiruma, Y, Joosten, R.P, Perrakis, A. | | 登録日 | 2016-07-18 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.
Proteins, 84, 2016
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5M0D
 | | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | | 分子名称: | CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2,Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, ... | | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | | 登録日 | 2016-10-04 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.
J. Med. Chem., 60, 2017
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5M0E
 | | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | | 分子名称: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | | 登録日 | 2016-10-04 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.
J. Med. Chem., 60, 2017
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5MRB
 | | Crystal structure of human Mps1 (TTK) in complex with Cpd-5 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Dual specificity protein kinase TTK, ... | | 著者 | Hiruma, Y, Joosten, R.P, Perrakis, A. | | 登録日 | 2016-12-22 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.
J. Biol. Chem., 292, 2017
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2X4Q
 | | Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, GLYCEROL, ... | | 著者 | Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M. | | 登録日 | 2010-02-02 | | 公開日 | 2010-03-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Class I Major Histocompatibility Complexes Loaded by a Periodate Trigger.
J.Am.Chem.Soc., 131, 2009
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2X4P
 | | Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-2-MICROGLOBULIN, GLYCEROL, ... | | 著者 | Celie, P.H.N, Toebes, M, Rodenko, B, Ovaa, H, Perrakis, A, Schumacher, T.N.M. | | 登録日 | 2010-02-02 | | 公開日 | 2010-03-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Class I Major Histocompatibility Complexes Loaded by a Periodate Trigger.
J.Am.Chem.Soc., 131, 2009
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7Z5G
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2X4T
 | | Crystal structure of MHC CLass I HLA-A2.1 bound to a Peiodate- cleavable peptide | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 65 KDA PHOSPHOPROTEIN, BETA-2-MICROGLOBULIN, ... | | 著者 | Rodenko, B, Toebes, M, Celie, P.H.N, Perrakis, A, Schumacher, T.N.M, Ovaa, H. | | 登録日 | 2010-02-02 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Class I Major Histocompatibility Complexes Loaded by a Periodate Trigger.
J.Am.Chem.Soc., 131, 2009
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2XR9
 | | Crystal structure of Autotaxin (ENPP2) | | 分子名称: | CALCIUM ION, ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, IODIDE ION, ... | | 著者 | Kamtekar, S, Hausmann, J, Day, J.E, Christodoulou, E, Perrakis, A. | | 登録日 | 2010-09-13 | | 公開日 | 2011-01-19 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
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