5LJJ
Crystal structure of human Mps1 (TTK) in complex with Reversine
Summary for 5LJJ
| Entry DOI | 10.2210/pdb5ljj/pdb |
| Descriptor | Dual specificity protein kinase TTK, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, 1,2-ETHANEDIOL (3 entities in total) |
| Functional Keywords | mps1, reversine, ttk, kinase, mitosis checkpoint, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 36630.84 |
| Authors | Hiruma, Y.,Joosten, R.P.,Perrakis, A. (deposition date: 2016-07-18, release date: 2016-10-12, Last modification date: 2024-01-31) |
| Primary citation | Hiruma, Y.,Koch, A.,Dharadhar, S.,Joosten, R.P.,Perrakis, A. Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase. Proteins, 84:1761-1766, 2016 Cited by PubMed: 27699881DOI: 10.1002/prot.25174 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report
