8T23
 
 | | Cryo-EM structure of the RBD-ACE2 interface of the SARS-CoV-2 trimeric spike protein bound to ACE2 receptor after local refinement at upRBD conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | | 登録日 | 2023-06-05 | | 公開日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2.
J Med Virol, 95, 2023
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8T20
 | | Cryo-EM structure of mink variant Y453F trimeric spike protein bound to two mink ACE2 receptors | | 分子名称: | Angiotensin-converting enzyme, Spike glycoprotein | | 著者 | Ahn, H.M, Calderon, B, Fan, X, Gao, Y, Horgan, N, Zhou, B, Liang, B. | | 登録日 | 2023-06-05 | | 公開日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2.
J Med Virol, 95, 2023
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1BLB
 | | CLOSE PACKING OF AN OLIGOMERIC EYE LENS BETA-CRYSTALLIN INDUCES LOSS OF SYMMETRY AND ORDERING OF SEQUENCE EXTENSIONS | | 分子名称: | BETA B2-CRYSTALLIN | | 著者 | Nalini, V, Bax, B, Driessen, H, Moss, D.S, Lindley, P.F, Slingsby, C. | | 登録日 | 1993-12-22 | | 公開日 | 1994-12-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Close packing of an oligomeric eye lens beta-crystallin induces loss of symmetry and ordering of sequence extensions.
J.Mol.Biol., 236, 1994
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1D8F
 | | CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR. | | 分子名称: | CALCIUM ION, N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYL-PIPERAZINE-2-CARBOXAMIDE, STROMELYSIN-1 PRECURSOR, ... | | 著者 | Cheng, M.Y, De, B, Pikul, S, Almstead, N.G, Natchus, M.G, Anastasio, M.V, McPhail, S.J, Snider, C.E, Taiwo, Y.O, Chen, L.Y. | | 登録日 | 1999-10-22 | | 公開日 | 2000-10-23 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.
J.Med.Chem., 43, 2000
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1D8M
 | | CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR | | 分子名称: | 1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE, CALCIUM ION, STROMELYSIN-1 PRECURSOR, ... | | 著者 | Pikul, S, Dunham, K.M, Almstead, N.G, De, B, Natchus, M.G, Taiwo, Y.O, Williams, L.E, Hynd, B.A, Hsieh, L.C, Janusz, M.J, Gu, F, Mieling, G.E. | | 登録日 | 1999-10-25 | | 公開日 | 2000-10-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Heterocycle-based MMP inhibitors with P2' substituents.
Bioorg.Med.Chem.Lett., 11, 2001
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1CZ8
 | | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY | | 分子名称: | HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... | | 著者 | Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. | | 登録日 | 1999-09-01 | | 公開日 | 2000-03-20 | | 最終更新日 | 2017-04-05 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
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1CXN
 | | REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE | | 分子名称: | CARDIOTOXIN GAMMA | | 著者 | Gilquin, B, Roumestand, C, Zinn-Justin, S, Menez, A, Toma, F. | | 登録日 | 1994-07-08 | | 公開日 | 1994-12-20 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined three-dimensional solution structure of a snake cardiotoxin: analysis of the side-chain organization suggests the existence of a possible phospholipid binding site.
Biopolymers, 33, 1993
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1CFF
 | | NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP | | 分子名称: | CALCIUM ION, CALCIUM PUMP, CALMODULIN | | 著者 | Elshorst, B, Hennig, M, Foersterling, H, Diener, A, Maurer, M, Schulte, P, Schwalbe, H, Krebs, J, Schmid, H, Vorherr, T, Carafoli, E, Griesinger, C. | | 登録日 | 1999-03-18 | | 公開日 | 1999-09-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump.
Biochemistry, 38, 1999
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1D2B
 | | THE MMP-INHIBITORY, N-TERMINAL DOMAIN OF HUMAN TISSUE INHIBITOR OF METALLOPROTEINASES-1 (N-TIMP-1), SOLUTION NMR, 29 STRUCTURES | | 分子名称: | Metalloproteinase inhibitor 1 | | 著者 | Wu, B, Arumugam, S, Semenchenko, V, Brew, K, Van Doren, S.R. | | 登録日 | 1999-09-22 | | 公開日 | 1999-12-22 | | 最終更新日 | 2022-03-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases.
J.Mol.Biol., 295, 2000
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1CGD
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1CXX
 | | MUTANT R122A OF QUAIL CYSTEINE AND GLYCINE-RICH PROTEIN, NMR, MINIMIZED STRUCTURE | | 分子名称: | CYSTEINE AND GLYCINE-RICH PROTEIN CRP2, ZINC ION | | 著者 | Kloiber, K, Weiskirchen, R, Kraeutler, B, Bister, K, Konrat, R. | | 登録日 | 1999-08-31 | | 公開日 | 1999-09-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mutational analysis and NMR spectroscopy of quail cysteine and glycine-rich protein CRP2 reveal an intrinsic segmental flexibility of LIM domains.
J.Mol.Biol., 292, 1999
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1CXO
 | | REFINED THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SNAKE CARDIOTOXIN: ANALYSIS OF THE SIDE-CHAIN ORGANISATION SUGGESTS THE EXISTENCE OF A POSSIBLE PHOSPHOLIPID BINDING SITE | | 分子名称: | CARDIOTOXIN GAMMA | | 著者 | Gilquin, B, Roumestand, C, Zinn-Justin, S, Menez, A, Toma, F. | | 登録日 | 1994-11-07 | | 公開日 | 1994-12-20 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined three-dimensional solution structure of a snake cardiotoxin: analysis of the side-chain organization suggests the existence of a possible phospholipid binding site.
Biopolymers, 33, 1993
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1CHC
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1CGE
 | | CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF | | 分子名称: | CALCIUM ION, FIBROBLAST COLLAGENASE, ZINC ION | | 著者 | Lovejoy, B, Hassell, A.M, Luther, M.A, Weigl, D, Jordan, S.R. | | 登録日 | 1994-02-03 | | 公開日 | 1995-03-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself.
Biochemistry, 33, 1994
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1CGF
 | | CRYSTAL STRUCTURES OF RECOMBINANT 19-KDA HUMAN FIBROBLAST COLLAGENASE COMPLEXED TO ITSELF | | 分子名称: | CALCIUM ION, FIBROBLAST COLLAGENASE, ZINC ION | | 著者 | Lovejoy, B, Hassell, A.M, Luther, M.A, Weigl, D, Jordan, S.R. | | 登録日 | 1994-02-03 | | 公開日 | 1995-03-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself.
Biochemistry, 33, 1994
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1DP8
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1D9X
 | | CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB | | 分子名称: | EXCINUCLEASE UVRABC COMPONENT UVRB, ZINC ION | | 著者 | Theis, K, Chen, P.J, Skorvaga, M, Van Houten, B, Kisker, C. | | 登録日 | 1999-10-30 | | 公開日 | 2000-05-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
EMBO J., 18, 1999
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1DCM
 | | STRUCTURE OF UNPHOSPHORYLATED FIXJ-N WITH AN ATYPICAL CONFORMER (MONOMER A) | | 分子名称: | MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN FIXJ | | 著者 | Gouet, P, Fabry, B, Guillet, V, Birck, C, Mourey, L, Kahn, D, Samama, J.P. | | 登録日 | 1999-11-05 | | 公開日 | 2000-11-08 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural transitions in the FixJ receiver domain.
Structure Fold.Des., 7, 1999
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1D9Z
 | | CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB IN COMPLEX WITH ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, EXCINUCLEASE UVRABC COMPONENT UVRB, MAGNESIUM ION, ... | | 著者 | Theis, K, Chen, P.J, Skorvaga, M, Van Houten, B, Kisker, C. | | 登録日 | 1999-10-30 | | 公開日 | 2000-05-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair.
EMBO J., 18, 1999
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1DDV
 | | CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE | | 分子名称: | GLGF-DOMAIN PROTEIN HOMER, METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 | | 著者 | Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J. | | 登録日 | 1999-11-11 | | 公開日 | 2000-05-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
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1DBW
 | | CRYSTAL STRUCTURE OF FIXJ-N | | 分子名称: | POLYETHYLENE GLYCOL (N=34), TRANSCRIPTIONAL REGULATORY PROTEIN FIXJ | | 著者 | Gouet, P, Fabry, B, Guillet, V, Birck, C, Mourey, L, Kahn, D, Samama, J.P. | | 登録日 | 1999-11-03 | | 公開日 | 1999-11-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural transitions in the FixJ receiver domain.
Structure Fold.Des., 7, 1999
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1DDW
 | | HOMER EVH1 DOMAIN UNLIGANDED | | 分子名称: | GLGF-DOMAIN PROTEIN HOMER | | 著者 | Beneken, J, Tu, J.C, Xiao, B, Worley, P.F, Leahy, D.J. | | 登録日 | 1999-11-11 | | 公開日 | 2000-05-10 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
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1DCK
 | | STRUCTURE OF UNPHOSPHORYLATED FIXJ-N COMPLEXED WITH MN2+ | | 分子名称: | MANGANESE (II) ION, POLYETHYLENE GLYCOL (N=34), TRANSCRIPTIONAL REGULATORY PROTEIN FIXJ | | 著者 | Gouet, P, Fabry, B, Guillet, V, Birck, C, Mourey, L, Kahn, D, Samama, J.P. | | 登録日 | 1999-11-05 | | 公開日 | 1999-11-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural transitions in the FixJ receiver domain.
Structure Fold.Des., 7, 1999
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4UWL
 | | Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors | | 分子名称: | (8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, SULFATE ION | | 著者 | Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B. | | 登録日 | 2014-08-12 | | 公開日 | 2014-11-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
J.Med.Chem., 58, 2015
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4UV6
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