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2GJZ
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BU of 2gjz by Molmil
Structure of Catalytic Elimination Antibody 13G5 from a crystal in space group P2(1)
分子名称: Catalytic elimination antibody 13G5 heavy chain, Catalytic elimination antibody 13G5 light chain, ZINC ION
著者Debler, E.W, Wilson, I.A.
登録日2006-03-31
公開日2007-02-06
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Bifunctional Catalysis of Proton Transfer at an Antibody Active Site.
J.Am.Chem.Soc., 129, 2007
2GK0
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BU of 2gk0 by Molmil
Structure of Catalytic Elimination Antibody 13G5 from a twinned crystal in space group C2
分子名称: Catalytic elimination antibody 13G5 heavy chain, Catalytic elimination antibody 13G5 light chain
著者Debler, E.W, Wilson, I.A.
登録日2006-03-31
公開日2007-02-06
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Bifunctional Catalysis of Proton Transfer at an Antibody Active Site.
J.Am.Chem.Soc., 129, 2007
3R08
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BU of 3r08 by Molmil
Crystal structure of mouse cd3epsilon in complex with antibody 2C11 Fab
分子名称: Mouse anti-mouse CD3epsilon antibody 2C11 heavy chain, Mouse anti-mouse CD3epsilon antibody 2C11 light chain, T-cell surface glycoprotein CD3 epsilon chain
著者Shore, D.A, Zhu, X, Wilson, I.A.
登録日2011-03-07
公開日2012-01-25
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.
J.Biol.Chem., 287, 2012
3R2X
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BU of 3r2x by Molmil
Crystal structure of the de novo designed binding protein HB36.3 in complex the the 1918 influenza virus hemagglutinin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HB36.3, designed hemagglutinin binding protein, ...
著者Ekiert, D.C, Wilson, I.A.
登録日2011-03-14
公開日2011-05-11
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Computational design of proteins targeting the conserved stem region of influenza hemagglutinin.
Science, 332, 2011
3OB0
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BU of 3ob0 by Molmil
A non-self sugar mimic of the HIV glycan shield shows enhanced antigenicity
分子名称: 7-deoxy-L-glycero-alpha-D-manno-heptopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose, Fab 2G12, heavy chain, ...
著者Doores, K.J, Fulton, Z, Hong, V, Patel, M.K, Scanlan, C.N, Wormald, M.R, Finn, M.G, Burton, D.R, Wilson, I.A, Davis, B.G.
登録日2010-08-06
公開日2011-01-12
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OAU
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BU of 3oau by Molmil
Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Non-Domain-Exchanged Forms, but only binds the HIV-1 Glycan Shield if Domain-Exchanged
分子名称: Fab 2G12, heavy chain, light chain, ...
著者Doores, K.J, Fulton, Z, Huber, M, Wilson, I.A, Burton, D.R.
登録日2010-08-05
公開日2011-01-12
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged.
J.Virol., 84, 2010
3QL3
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BU of 3ql3 by Molmil
Re-refined coordinates for PDB entry 1RX2
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A.
登録日2011-02-02
公開日2011-04-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.
Science, 332, 2011
2I27
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BU of 2i27 by Molmil
Crystal Structure Analysis of the Nurse Shark New Antigen Receptor Ancestral variable domain
分子名称: New Antigen Receptor Ancestral
著者Stanfield, R.L, Wilson, I.A.
登録日2006-08-15
公開日2007-03-06
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Maturation of Shark Single-domain (IgNAR) Antibodies: Evidence for Induced-fit Binding.
J.Mol.Biol., 367, 2007
2I24
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BU of 2i24 by Molmil
Crystal structure analysis of the nurse shark New Antigen Receptor PBLA8 variable domain
分子名称: CHLORIDE ION, New Antigen Receptor PBLA8
著者Stanfield, R.L, Wilson, I.A.
登録日2006-08-15
公開日2007-03-06
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Maturation of Shark Single-domain (IgNAR) Antibodies: Evidence for Induced-fit Binding
J.Mol.Biol., 367, 2007
2I26
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BU of 2i26 by Molmil
Crystal structure analysis of the nurse shark new antigen receptor ancestral variable domain in complex with lysozyme
分子名称: Lysozyme C, New Antigen Receptor Ancestral, SULFATE ION
著者Stanfield, R.L, Wilson, I.A.
登録日2006-08-15
公開日2007-03-06
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Maturation of Shark Single-domain (IgNAR) Antibodies: Evidence for Induced-fit Binding.
J.Mol.Biol., 367, 2007
6BKM
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BU of 6bkm by Molmil
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant apo form
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Wu, N.C, Wilson, I.A.
登録日2017-11-09
公開日2018-02-28
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nat Commun, 9, 2018
6BKT
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BU of 6bkt by Molmil
Crystal structure of the A/Michigan/15/2014 (H3N2) influenza virus hemagglutinin in complex with 6'-SLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
著者Wu, N.C, Wilson, I.A.
登録日2017-11-09
公開日2018-02-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nat Commun, 9, 2018
5UF1
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BU of 5uf1 by Molmil
Crystal Structure of Variable Lymphocyte Receptor (VLR) O13 in complex with H-trisaccharide
分子名称: CHLORIDE ION, O13, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gunn, R.J, Collins, B.C, McKitrick, T.R, Cummings, R.D, Cooper, M.D, Herrin, B.R, Wilson, I.A.
登録日2017-01-03
公開日2017-10-18
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates.
Structure, 25, 2017
7KN3
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BU of 7kn3 by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-B8 Fab
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, S-B8 Fab heavy chain, ...
著者Liu, H, Zhu, X, Wilson, I.A.
登録日2020-11-04
公開日2021-09-22
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago.
Adv Sci, 9, 2022
7KN4
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BU of 7kn4 by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-E6 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, S-E6 Fab heavy chain, S-E6 Fab light chain, ...
著者Liu, H, Wilson, I.A.
登録日2020-11-04
公開日2021-09-22
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago.
Adv Sci, 9, 2022
5UFC
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BU of 5ufc by Molmil
Crystal Structure of Variable Lymphocyte Receptor (VLR) Tn4-22 with H-trisaccharide bound
分子名称: Tn4-22, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Collins, B.C, Gunn, R.J, McKitrick, T.R, Cummings, R.D, Cooper, M.D, Herrin, B.R, Wilson, I.A.
登録日2017-01-04
公開日2017-10-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.888 Å)
主引用文献Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates.
Structure, 25, 2017
6D0U
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BU of 6d0u by Molmil
Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 V110P/A117E mutant, heavy chain, ...
著者Wu, N.C, Wilson, I.A.
登録日2018-04-11
公開日2019-01-16
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5UI4
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BU of 5ui4 by Molmil
Structure of NME1 covalently conjugated to imidazole fluorosulfate
分子名称: 4-[4-(3-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-5-yl]phenyl sulfurofluoridate, Nucleoside diphosphate kinase A
著者Mortenson, D.E, Brighty, G.J, Wilson, I.A, Kelly, J.W.
登録日2017-01-12
公開日2018-01-17
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.
J. Am. Chem. Soc., 140, 2018
6CF7
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BU of 6cf7 by Molmil
Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Kadam, R.U, Wilson, I.A.
登録日2018-02-13
公開日2019-02-13
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science, 363, 2019
6CXL
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anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5
分子名称: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, anti-HIV-1 Fab 2G12 heavy chain, anti-HIV-1 Fab 2G12 light chain
著者Stanfield, R.L, Wilson, I.A.
登録日2018-04-03
公開日2019-02-20
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.586 Å)
主引用文献Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5, 2019
6D2P
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BU of 6d2p by Molmil
Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
分子名称: GLYCEROL, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, ...
著者Sarkar, A, Wilson, I.A.
登録日2018-04-13
公開日2019-01-16
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Sci Transl Med, 10, 2018
1ES0
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BU of 1es0 by Molmil
CRYSTAL STRUCTURE OF THE MURINE CLASS II ALLELE I-A(G7) COMPLEXED WITH THE GLUTAMIC ACID DECARBOXYLASE (GAD65) PEPTIDE 207-220
分子名称: 65 KD GLUTAMIC ACID DECARBOXYLASE+H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN
著者Corper, A.L, Teyton, L, Wilson, I.A.
登録日2000-04-07
公開日2000-06-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.
Science, 288, 2000
5UM8
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BU of 5um8 by Molmil
Crystal structure of HIV-1 envelope trimer 16055 NFL TD CC (T569G) in complex with Fabs 35022 and PGT124
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 35022 heavy chain, ...
著者Garces, F, Stanfield, R.L, Wilson, I.A.
登録日2017-01-26
公開日2017-05-24
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.935 Å)
主引用文献Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.
Immunity, 46, 2017
6CXG
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anti-HIV-1 Fab 2G12 in complex with glycopeptide 10V1S
分子名称: 10V1S glycopeptide, GLYCEROL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, ...
著者Stanfield, R.L, Wilson, I.A.
登録日2018-04-03
公開日2019-02-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5, 2019
5V2A
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Crystal structure of Fab H7.167 in complex with influenza virus hemagglutinin from A/Shanghai/02/2013 (H7N9)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H7.167 antibody, Hemagglutinin, ...
著者Zhang, H, Zhu, X, Wilson, I.A.
登録日2017-03-03
公開日2017-04-05
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (4.656 Å)
主引用文献H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
J. Clin. Invest., 126, 2016

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