8VW5
 
 | | Crystal structure of Cbl-b TKB bound to compound 2 | | 分子名称: | CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ... | | 著者 | Yu, C, Murray, J, Hsu, P.L. | | 登録日 | 2024-01-31 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
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8VW4
 | | Crystal structure of Cbl-b TKB bound to compound 26 | | 分子名称: | (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ... | | 著者 | Yu, C, Murray, J, Hsu, P.L. | | 登録日 | 2024-01-31 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
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3PV7
 | | Crystal structure of NKp30 ligand B7-H6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167 | | 著者 | Li, Y. | | 登録日 | 2010-12-06 | | 公開日 | 2011-03-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of the activating natural killer cell receptor NKp30 bound to its ligand B7-H6 reveals basis for tumor cell recognition in humans
to be published
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7DHX
 | | Crystal structure of SARS-CoV-2 RBD binding to pangolin ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ZINC ION, ... | | 著者 | Wang, Q.H, Qi, J.X, Wu, L.L. | | 登録日 | 2020-11-17 | | 公開日 | 2021-09-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular basis of pangolin ACE2 engaged by COVID-19 virus
Chin.Sci.Bull., 66, 2021
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7DFG
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7DFH
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7DOK
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7DOI
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4Q2V
 | | Crystal Structure of Ricin A chain complexed with Baicalin inhibitor | | 分子名称: | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, Ricin | | 著者 | Deng, X, Li, X, Dong, J, Chen, Y. | | 登録日 | 2014-04-10 | | 公開日 | 2015-04-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization.
J.Biol.Chem., 290, 2015
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4MOD
 | | Structure of the MERS-CoV fusion core | | 分子名称: | HR1 of S protein, LINKER, HR2 of S protein | | 著者 | Gao, J, Lu, G, Qi, J, Li, Y, Wu, Y, Deng, Y, Geng, H, Xiao, H, Tan, W, Yan, J, Gao, G.F. | | 登録日 | 2013-09-12 | | 公開日 | 2013-10-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus.
J.Virol., 87, 2013
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4QGU
 | | protein domain complex with ssDNA | | 分子名称: | DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3'), Gamma-interferon-inducible protein 16 | | 著者 | Ni, X, Ru, H, Zhao, L, Shaw, N, Ding, W, Songying, O, Liu, Z.-J. | | 登録日 | 2014-05-25 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.545 Å) | | 主引用文献 | New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16.
J Mol Cell Biol, 8, 2016
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8JJL
 | | cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist | | 分子名称: | Beta-2 adrenergic receptor,Soluble cytochrome b562, Olodaterol | | 著者 | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | 登録日 | 2023-05-30 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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6LQZ
 | | Solution structure of Taf14ET-Sth1EBMC | | 分子名称: | Nuclear protein STH1/NPS1, Transcription initiation factor TFIID subunit 14 | | 著者 | Wu, B, Chen, G, Chen, Y. | | 登録日 | 2020-01-15 | | 公開日 | 2020-08-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation.
Nat Commun, 11, 2020
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8J7E
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8JJO
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist | | 分子名称: | (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562 | | 著者 | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | 登録日 | 2023-05-31 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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4IOP
 | | Crystal structure of NKp65 bound to its ligand KACL | | 分子名称: | C-type lectin domain family 2 member A, Killer cell lectin-like receptor subfamily F member 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Li, Y. | | 登録日 | 2013-01-08 | | 公開日 | 2013-07-17 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex.
Proc.Natl.Acad.Sci.USA, 110, 2013
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8JMT
 | | Structure of the adhesion GPCR ADGRL3 in the apo state | | 分子名称: | Adhesion G protein-coupled receptor L3,Soluble cytochrome b562 | | 著者 | Tao, Y, Guo, Q, He, B, Zhong, Y. | | 登録日 | 2023-06-05 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8JJ8
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist | | 分子名称: | Beta-2 adrenergic receptor,Soluble cytochrome b562, ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide | | 著者 | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | 登録日 | 2023-05-29 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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4I1L
 | | Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function | | 分子名称: | ACETATE ION, Forkhead box protein P3, MAGNESIUM ION, ... | | 著者 | Song, X.M, Greene, M.I, Zhou, Z.C. | | 登録日 | 2012-11-21 | | 公開日 | 2012-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.
Cell Rep, 1, 2012
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4RSU
 | | Crystal structure of the light and hvem complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | | 著者 | Liu, W, Ramagoal, U.A, Himmel, D, Bonanno, J.B, Nathenson, S.G, Almo, S.C, Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2014-11-11 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
J.Exp.Med., 218, 2021
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7D4F
 | | Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin | | 分子名称: | 8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Li, Z, Yin, W, Zhou, Z, Yu, X, Xu, H. | | 登録日 | 2020-09-23 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.
Nat.Struct.Mol.Biol., 28, 2021
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8SNX
 | | Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoter | | 分子名称: | Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*GP*CP*GP*U)-3'), RNA-directed RNA polymerase L | | 著者 | Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. | | 登録日 | 2023-04-28 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
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8SNY
 | | Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter | | 分子名称: | Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*UP*CP*GP*U)-3'), RNA-directed RNA polymerase L | | 著者 | Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. | | 登録日 | 2023-04-28 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
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6IZQ
 | | PRMT4 bound with a bicyclic compound | | 分子名称: | (2R)-1-(methylamino)-3-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)propan-2-ol, Histone-arginine methyltransferase CARM1 | | 著者 | Xiong, B, Cao, D.Y, Guo, Z.H, Li, Y.L, Li, J, Huang, X, Shen, J.K. | | 登録日 | 2018-12-20 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.449 Å) | | 主引用文献 | Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
J.Med.Chem., 62, 2019
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8HWT
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