2AYR
 
 | | A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats | | 分子名称: | 6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL, Estrogen receptor | | 著者 | Hummel, C.W, Geiser, A.G, Bryant, H.U, Cohen, I.R, Dally, R.D, Fong, K.C, Frank, S.A, Hinklin, R, Jones, S.A, Lewis, G, McCann, D.J, Shepherd, T.A, Tian, H, Rudman, D.G, Wallace, O.B, Wang, Y, Dodge, J.A. | | 登録日 | 2005-09-07 | | 公開日 | 2005-11-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats
J.Med.Chem., 48, 2005
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1YU5
 | | Crystal Structure of the Headpiece Domain of Chicken Villin | | 分子名称: | Villin | | 著者 | Meng, J, Vardar, D, Wang, Y, Guo, H.C, Head, J.F, McKnight, C.J. | | 登録日 | 2005-02-11 | | 公開日 | 2005-09-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | High-resolution crystal structures of villin headpiece and mutants with reduced f-actin binding activity.
Biochemistry, 44, 2005
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1YU8
 | | Crystal Structure of the R37A Mutant of Villin Headpiece | | 分子名称: | Villin | | 著者 | Meng, J, Vardar, D, Wang, Y, Guo, H.C, Head, J.F, McKnight, C.J. | | 登録日 | 2005-02-12 | | 公開日 | 2005-09-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity.
Biochemistry, 44, 2005
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1ZUB
 | | Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide | | 分子名称: | ELKS1b, Regulating synaptic membrane exocytosis protein 1 | | 著者 | Lu, J, Li, H, Wang, Y, Sudhof, T.C, Rizo, J. | | 登録日 | 2005-05-30 | | 公開日 | 2005-08-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the RIM1alpha PDZ Domain in Complex with an ELKS1b C-terminal Peptide
J.Mol.Biol., 352, 2005
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2B5F
 | | Crystal structure of the spinach aquaporin SoPIP2;1 in an open conformation to 3.9 resolution | | 分子名称: | aquaporin | | 著者 | Tornroth-Horsefield, S, Wang, Y, Hedfalk, K, Johanson, U, Karlsson, M, Tajkhorshid, E, Neutze, R, Kjellbom, P. | | 登録日 | 2005-09-28 | | 公開日 | 2005-12-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Structural mechanism of plant aquaporin gating
Nature, 439, 2006
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2F0X
 | | Crystal structure and function of human thioesterase superfamily member 2(THEM2) | | 分子名称: | SULFATE ION, Thioesterase superfamily member 2 | | 著者 | Cheng, Z, Song, F, Shan, X, Wang, Y, Wei, Z, Gong, W. | | 登録日 | 2005-11-14 | | 公開日 | 2006-10-10 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of human thioesterase superfamily member 2
Biochem.Biophys.Res.Commun., 349, 2006
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2CPU
 | | SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | | 分子名称: | ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION | | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | | 登録日 | 1999-06-08 | | 公開日 | 2001-06-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
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1ZLM
 | | Crystal structure of the SH3 domain of human osteoclast stimulating factor | | 分子名称: | Osteoclast stimulating factor 1 | | 著者 | Chen, L, Wang, Y, Wells, D, Toh, D, Harold, H, Zhou, J, DiGiammarino, E, Meehan, E.J. | | 登録日 | 2005-05-06 | | 公開日 | 2006-05-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | | 主引用文献 | Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution.
Acta Crystallogr.,Sect.F, 62, 2006
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6LTU
 | | Crystal structure of Cas12i2 ternary complex with double Mg2+ bound in catalytic pocket | | 分子名称: | 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ... | | 著者 | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | | 登録日 | 2020-01-23 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
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6LTR
 | | Crystal structure of Cas12i2 ternary complex with single Mg2+ bound in catalytic pocket | | 分子名称: | 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ... | | 著者 | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | | 登録日 | 2020-01-23 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
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6LU0
 | | Crystal structure of Cas12i2 ternary complex with 12 nt spacer | | 分子名称: | Cas12i2, DNA (5'-D(*GP*CP*CP*GP*CP*TP*TP*TP*CP*TP*T)-3'), DNA (5'-D(*GP*CP*TP*TP*GP*CP*TP*CP*TP*GP*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*C)-3'), ... | | 著者 | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | | 登録日 | 2020-01-24 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
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6LTP
 | | Crystal structure of Cas12i2 binary complex | | 分子名称: | Cas12i2, crRNA (56-mer RNA) | | 著者 | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | | 登録日 | 2020-01-23 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2.
Nat Commun, 11, 2020
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3RJY
 | | Crystal Structure of Hyperthermophilic Endo-beta-1,4-glucanase in complex with substrate | | 分子名称: | Endoglucanase FnCel5A, PHOSPHATE ION, alpha-D-glucopyranose | | 著者 | Zheng, B, Yang, W, Zhao, X, Wang, Y, Lou, Z, Rao, Z, Feng, Y. | | 登録日 | 2011-04-15 | | 公開日 | 2012-02-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of hyperthermophilic Endo-beta-1,4-glucanase: Implications for catalytic mechanism and thermostability.
J.Biol.Chem., 287, 2012
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3CIY
 | | Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Liu, L, Botos, I, Wang, Y, Leonard, J.N, Shiloach, J, Segal, D.M, Davies, D.R. | | 登録日 | 2008-03-12 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | | 主引用文献 | Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Science, 320, 2008
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4LEJ
 | | Crystal Structure of the Korean pine (Pinus koraiensis) vicilin | | 分子名称: | COPPER (II) ION, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Jin, T.C, Wang, Y, Zhang, Y.Z. | | 登録日 | 2013-06-25 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Crystal Structure of Korean Pine ( Pinus koraiensis ) 7S Seed Storage Protein with Copper Ligands.
J.Agric.Food Chem., 62, 2014
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3CPU
 | | SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | | 分子名称: | CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ... | | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | | 登録日 | 1999-06-08 | | 公開日 | 2001-06-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
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5XAF
 | | Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex | | 分子名称: | (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Zhang, H, Luo, C, Wang, Y. | | 登録日 | 2017-03-12 | | 公開日 | 2017-12-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
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6LP2
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7W3X
 | | Cryo-EM structure of plant receptor like protein RXEG1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Membrane-localized LRR receptor-like protein, ... | | 著者 | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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6LW4
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6AX3
 | | Complex structure of JMJD5 and Symmetric Dimethyl-Arginine (SDMA) | | 分子名称: | 2-OXOGLUTARIC ACID, Lysine-specific demethylase 8, N3, ... | | 著者 | Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. | | 登録日 | 2017-09-06 | | 公開日 | 2018-02-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Sci Rep, 8, 2018
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8JFQ
 | | Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-back Loop | | 分子名称: | 26mer-DNA | | 著者 | Liu, Y, Li, J, Zhang, Y, Wang, Y, Chen, J, Bian, Y, Xia, Y, Yang, M.H, Zheng, K, Wang, K.B, Kong, L.Y. | | 登録日 | 2023-05-18 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the Major G-Quadruplex in the Human EGFR Oncogene Promoter Adopts a Unique Folding Topology with a Distinctive Snap-Back Loop.
J.Am.Chem.Soc., 145, 2023
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5XAG
 | | Crystal structure of tubulin-stathmin-TTL-Compound Z2 complex | | 分子名称: | (3~{R},4~{R})-3-(hydroxymethyl)-4-(4-methoxy-3-oxidanyl-phenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Zhang, H, Luo, C, Wang, Y. | | 登録日 | 2017-03-12 | | 公開日 | 2018-01-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
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6AVS
 | | Complex structure of JMJD5 and Symmetric Monomethyl-Arginine (MMA) | | 分子名称: | (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, Lysine-specific demethylase 8, ZINC ION | | 著者 | Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. | | 登録日 | 2017-09-04 | | 公開日 | 2018-02-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.
Sci Rep, 8, 2018
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7W3V
 | | Plant receptor like protein RXEG1 in complex with xyloglucanase XEG1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cell 12A endoglucanase, ... | | 著者 | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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