8CZ5
 
 | N11 P domain 2D9 Fab P complex | 分子名称: | ACETATE ION, CADMIUM ION, Fab 2D9 Heavy Chain, ... | 著者 | Leuthold, M, Kilic, T, Hansman, G. | 登録日 | 2022-05-24 | 公開日 | 2022-10-19 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | 主引用文献 | Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity. J.Virol., 96, 2022
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8TBQ
 
 | The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ... | 著者 | van der Horst, E.H, Mukherjee, A, Thisted, T. | 登録日 | 2023-06-29 | 公開日 | 2024-03-20 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.593 Å) | 主引用文献 | VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response. Nat Commun, 15, 2024
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7SGG
 
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7SGK
 
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9JJ7
 
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9JHX
 
 | Versatile Aromatic Prenyltransferase auraA mutant-Y207A in complex with DMSPP | 分子名称: | DIMETHYLALLYL S-THIOLODIPHOSPHATE, Versatile Aromatic Prenyltransferase auraA | 著者 | Li, D, Zhang, Y, Wang, W, Wang, P. | 登録日 | 2024-09-10 | 公開日 | 2025-02-05 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines. Nat Commun, 16, 2025
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7WX2
 
 | CBP-BrD complexed with NEO2734 | 分子名称: | 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one, CREB-binding protein | 著者 | Zeng, L, Lei, J.D. | 登録日 | 2022-02-14 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer. Oncogene, 41, 2022
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7WWZ
 
 | BRD4-BD1 complexed with NEO2734 | 分子名称: | 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one, Isoform C of Bromodomain-containing protein 4 | 著者 | Zeng, L, Lei, J.D. | 登録日 | 2022-02-14 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer. Oncogene, 41, 2022
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6ILM
 
 | Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4 | 分子名称: | Beta-2-microglobulin, Capsid protein VP1, Capsid protein VP2, ... | 著者 | Gao, G.F, Liu, S, Zhao, X, Peng, R. | 登録日 | 2018-10-19 | 公開日 | 2019-05-15 | 最終更新日 | 2025-06-25 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell, 177, 2019
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6P5A
 
 | Drosophila P element transposase strand transfer complex | 分子名称: | DNA (44-MER), DNA (5'-D(P*AP*GP*GP*TP*GP*GP*TP*CP*CP*CP*GP*TP*CP*GP*G)-3'), DNA (5'-D(P*CP*GP*AP*AP*CP*TP*AP*TP*A)-3'), ... | 著者 | Kellogg, E.H, Nogales, E, Ghanim, G, Rio, D.C. | 登録日 | 2019-05-30 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts. Nat.Struct.Mol.Biol., 26, 2019
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6ILP
 
 | Cryo-EM structure of full Echovirus 6 particle at PH 7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Gao, G.F, Liu, S, Zhao, X, Peng, R. | 登録日 | 2018-10-19 | 公開日 | 2019-05-15 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell, 177, 2019
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6ILN
 
 | Cryo-EM structure of full Echovirus 6 particle at PH 5.5 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Gao, G.F, Liu, S, Zhao, X, Peng, R. | 登録日 | 2018-10-19 | 公開日 | 2019-05-15 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell, 177, 2019
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6PE2
 
 | Drosophila P element transposase strand transfer complex | 分子名称: | DNA (27-MER), DNA (5'-D(P*CP*GP*AP*AP*CP*TP*AP*TP*A)-3'), DNA (56-MER), ... | 著者 | Kellogg, E.H, Nogales, E, Ghanim, G, Rio, D.C. | 登録日 | 2019-06-19 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts. Nat.Struct.Mol.Biol., 26, 2019
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8Y9E
 
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8Y7T
 
 | Crystal structure of SARS-CoV-2 main protease in complex with C2 | 分子名称: | 3C-like proteinase nsp5, 6-(iminomethyl)-4-(2-pyridin-2-ylethyl)-2-[4-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5-dione | 著者 | Zeng, R, Deng, X.Y, Yang, Z.Y, Wang, K, Jiang, Y.Y, Lei, J. | 登録日 | 2024-02-05 | 公開日 | 2025-02-05 | 最終更新日 | 2025-04-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor. Eur.J.Med.Chem., 291, 2025
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8Y9D
 
 | Versatile Aromatic Prenyltransferase auraA in complex with DMAPP and cyclo-(L-Val-L-His) | 分子名称: | (3~{S},6~{S})-3-(1~{H}-imidazol-4-ylmethyl)-6-propan-2-yl-piperazine-2,5-dione, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Versatile Aromatic Prenyltransferase auraA | 著者 | Li, D, Zhang, Y, Wang, W, Wang, P. | 登録日 | 2024-02-06 | 公開日 | 2025-02-05 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines. Nat Commun, 16, 2025
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8Y7U
 
 | Crystal structure of SARS-CoV-2 main protease in complex with C5 | 分子名称: | 2-(3-fluoro-4-(trifluoromethyl)phenyl)-6-(iminomethyl)-4-(2-oxo-2-(pyridin-2-yl)ethyl)-1,2,4-triazine-3,5(2H,4H)-dione, 3C-like proteinase nsp5 | 著者 | Zeng, R, Deng, X.Y, Yang, Z.Y, Wang, K, Jiang, Y.Y, Lei, J. | 登録日 | 2024-02-05 | 公開日 | 2025-02-05 | 最終更新日 | 2025-04-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor. Eur.J.Med.Chem., 291, 2025
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8Y9G
 
 | Versatile Aromatic Prenyltransferase auraA in complex with DMSPP and cyclo-(L-Val-DH-His) | 分子名称: | (3~{Z},6~{S})-3-(1~{H}-imidazol-4-ylmethylidene)-6-propan-2-yl-piperazine-2,5-dione, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Versatile Aromatic Prenyltransferase auraA | 著者 | Li, D, Zhang, Y, Wang, W, Wang, P. | 登録日 | 2024-02-06 | 公開日 | 2025-02-05 | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | 主引用文献 | Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines. Nat Commun, 16, 2025
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5ER2
 
 | High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor. the analysis of the inhibitor binding and description of the rigid body shift in the enzyme | 分子名称: | 6-ammonio-N-{[(2R,3R)-3-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-4-cyclohexyl-2-hydroxybutyl](2-methylpropyl)carbamoyl}-L-norleucyl-L-phenylalanine, ENDOTHIAPEPSIN | 著者 | Sali, A, Veerapandian, B, Cooper, J.B, Foundling, S.I, Hoover, D.J, Blundell, T.L. | 登録日 | 1991-01-02 | 公開日 | 1991-04-15 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme. EMBO J., 8, 1989
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8K0D
 
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8K0C
 
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6ILK
 
 | Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 7.4 | 分子名称: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | 著者 | Gao, G.F, Liu, S, Zhao, X, Peng, R. | 登録日 | 2018-10-18 | 公開日 | 2019-05-15 | 最終更新日 | 2025-06-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Cell, 177, 2019
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8EN4
 
 | Structure of GII.4 norovirus in complex with Nanobody 53 | 分子名称: | 1,2-ETHANEDIOL, Nanobody 53, VP1 | 著者 | Kher, G, Sabin, C, Koromyslova, A, Pancera, M, Hansman, G. | 登録日 | 2022-09-28 | 公開日 | 2023-03-15 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies. J.Virol., 97, 2023
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8EN5
 
 | Structure of GII.4 norovirus in complex with Nanobody 56 | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GII.4 P domain, ... | 著者 | Kher, G, Sabin, C, Pancera, M, Koromyslova, A, Hansman, G. | 登録日 | 2022-09-28 | 公開日 | 2023-03-15 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies. J.Virol., 97, 2023
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8EMZ
 
 | Structure of GII.17 norovirus in complex with Nanobody 2 | 分子名称: | 1,2-ETHANEDIOL, GII.17 P domain, Nanobody 2 | 著者 | Kher, G, Sabin, C, Pancera, M, Koromyslova, A, Hansman, G. | 登録日 | 2022-09-28 | 公開日 | 2023-03-15 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies. J.Virol., 97, 2023
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