5YR0
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![BU of 5yr0 by Molmil](/molmil-images/mine/5yr0) | Structure of Beclin1-UVRAG coiled coil domain complex | 分子名称: | Beclin-1, UV radiation resistance associated protein | 著者 | Pan, X, Zhao, Y, He, Y. | 登録日 | 2017-11-08 | 公開日 | 2018-06-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2YOJ
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![BU of 2yoj by Molmil](/molmil-images/mine/2yoj) | HCV NS5B polymerase complexed with pyridonylindole compound | 分子名称: | 4-fluoranyl-6-[(7-fluoranyl-4-oxidanylidene-3H-quinazolin-6-yl)methyl]-8-(2-oxidanylidene-1H-pyridin-3-yl)furo[2,3-e]indole-7-carboxylic acid, PHOSPHATE ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Chen, K.X, Venkatraman, S, Anilkumar, G.N, Zeng, Q, Lesburg, C.A, Vibulbhan, B, Yang, W, Velazquez, F, Chan, T.-Y, Bennett, F, Sannigrahi, M, Jiang, Y, Duca, J.S, Pinto, P, Gavalas, S, Huang, Y, Wu, W, Selyutin, O, Agrawal, S, Feld, B, Huang, H.-C, Li, C, Cheng, K.-C, Shih, N.-Y, Kozlowski, J.A, Rosenblum, S.B, Njoroge, F.G. | 登録日 | 2012-10-24 | 公開日 | 2013-10-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Discovery of Sch 900188: A Potent Hepatitis C Virus Ns5B Polymerase Inhibitor Prodrug as a Development Candidate Acs Med.Chem.Lett., 5, 2014
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2LFN
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![BU of 2lfn by Molmil](/molmil-images/mine/2lfn) | Identification of the key regions that drive functional amyloid formation by the fungal hydrophobin EAS | 分子名称: | Hydrophobin | 著者 | Macindoe, I, Kwan, A.H, Morris, V.K, Mackay, J.P, Sunde, M. | 登録日 | 2011-07-06 | 公開日 | 2012-01-25 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS Proc.Natl.Acad.Sci.USA, 109, 2012
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4N9J
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![BU of 4n9j by Molmil](/molmil-images/mine/4n9j) | Crystal structure of the cryptic polo box domain of human Plk4 | 分子名称: | CHLORIDE ION, SULFATE ION, Serine/threonine-protein kinase PLK4 | 著者 | Ku, B, Kim, J.H, Lee, K.S, Kim, S.J. | 登録日 | 2013-10-21 | 公開日 | 2014-07-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat.Struct.Mol.Biol., 21, 2014
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4ICK
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![BU of 4ick by Molmil](/molmil-images/mine/4ick) | Crystal structure of human AP4A hydrolase E58A mutant | 分子名称: | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], GLYCEROL, MAGNESIUM ION, ... | 著者 | Ge, H, Chen, X. | 登録日 | 2012-12-10 | 公開日 | 2013-12-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of wild-type and mutant human Ap4A hydrolase. Biochem.Biophys.Res.Commun., 432, 2013
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7XEM
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![BU of 7xem by Molmil](/molmil-images/mine/7xem) | Cholesterol bound state of mTRPV2 | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEO
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![BU of 7xeo by Molmil](/molmil-images/mine/7xeo) | MbetaCD treated state of mTRPV2 | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEV
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![BU of 7xev by Molmil](/molmil-images/mine/7xev) | Structure of mTRPV2_2-APB | 分子名称: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEU
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![BU of 7xeu by Molmil](/molmil-images/mine/7xeu) | Structure of mTRPV2_E2 | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XEW
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![BU of 7xew by Molmil](/molmil-images/mine/7xew) | Structure of mTRPV2_Q525F | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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7XER
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![BU of 7xer by Molmil](/molmil-images/mine/7xer) | Structure of mTRPV2_Q525T | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-03-31 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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4IJX
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7YEP
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![BU of 7yep by Molmil](/molmil-images/mine/7yep) | 2-APB bound state of mTRPV2 | 分子名称: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | 著者 | Su, N. | 登録日 | 2022-07-06 | 公開日 | 2022-08-17 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands. Nat.Chem.Biol., 19, 2023
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4J3D
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![BU of 4j3d by Molmil](/molmil-images/mine/4j3d) | Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor | 分子名称: | N~1~-hydroxy-N~5~-(3-hydroxypropyl)-N~2~-[4-(phenylethynyl)benzoyl]-L-glutamamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | 著者 | Lahiri, S. | 登録日 | 2013-02-05 | 公開日 | 2013-04-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Exploring the UDP pocket of LpxC through amino acid analogs. Bioorg.Med.Chem.Lett., 23, 2013
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6AUD
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![BU of 6aud by Molmil](/molmil-images/mine/6aud) | PI3K-gamma K802T in complex with Cpd 8 10-((1-(tert-butyl)piperidin-4-yl)sulfinyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine | 分子名称: | 10-[(S)-(1-tert-butylpiperidin-4-yl)sulfinyl]-2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Murray, J.M, Ultsch, M. | 登録日 | 2017-08-31 | 公開日 | 2017-11-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.015 Å) | 主引用文献 | Design of Selective Benzoxazepin PI3K delta Inhibitors Through Control of Dihedral Angles. ACS Med Chem Lett, 8, 2017
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7YDX
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![BU of 7ydx by Molmil](/molmil-images/mine/7ydx) | Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | 分子名称: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | 著者 | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | 登録日 | 2022-07-04 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.642 Å) | 主引用文献 | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun, 13, 2022
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6C0S
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7T3V
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![BU of 7t3v by Molmil](/molmil-images/mine/7t3v) | Metal dependent activation of Plasmodium falciparum M17 aminopeptidase, spacegroup P22121 after crystals soaked with Zn2+ | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CARBONATE ION, M17 leucyl aminopeptidase, ... | 著者 | Webb, C.T, McGowan, S. | 登録日 | 2021-12-08 | 公開日 | 2022-06-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase. J.Biol.Chem., 298, 2022
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7TO4
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![BU of 7to4 by Molmil](/molmil-images/mine/7to4) | Structural and functional impact by SARS-CoV-2 Omicron spike mutations | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2022-01-22 | 公開日 | 2022-02-16 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep, 39, 2022
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7TNW
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![BU of 7tnw by Molmil](/molmil-images/mine/7tnw) | Structural and functional impact by SARS-CoV-2 Omicron spike mutations | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2022-01-21 | 公開日 | 2022-02-16 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep, 39, 2022
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7SBQ
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![BU of 7sbq by Molmil](/molmil-images/mine/7sbq) | One RBD-up 1 of pre-fusion SARS-CoV-2 Kappa variant spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2021-09-25 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science, 374, 2021
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7SBP
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![BU of 7sbp by Molmil](/molmil-images/mine/7sbp) | Closed state of pre-fusion SARS-CoV-2 Kappa variant spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2021-09-25 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science, 374, 2021
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7SBR
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![BU of 7sbr by Molmil](/molmil-images/mine/7sbr) | One RBD-up 2 of pre-fusion SARS-CoV-2 Kappa variant spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2021-09-25 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science, 374, 2021
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7SBO
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![BU of 7sbo by Molmil](/molmil-images/mine/7sbo) | One RBD-up 2 of pre-fusion SARS-CoV-2 Delta variant spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2021-09-25 | 公開日 | 2021-11-03 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science, 374, 2021
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7SBT
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![BU of 7sbt by Molmil](/molmil-images/mine/7sbt) | One RBD-up 2 of pre-fusion SARS-CoV-2 Gamma variant spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, J, Xiao, T.S, Cai, Y.F, Peng, H.Q, Volloch, S.R, Chen, B. | 登録日 | 2021-09-25 | 公開日 | 2021-11-10 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science, 374, 2021
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