7X8A
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![BU of 7x8a by Molmil](/molmil-images/mine/7x8a) | Cryo-EM structure of a bacterial protein complex | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-11 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
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7XC7
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![BU of 7xc7 by Molmil](/molmil-images/mine/7xc7) | Cryo-EM structure of a bacterial protein complex | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (33-MER), ... | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-23 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
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7X7A
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![BU of 7x7a by Molmil](/molmil-images/mine/7x7a) | Cryo-EM structure of SbCas7-11 in complex with crRNA and target RNA | 分子名称: | RAMP superfamily protein, RNA (33-MER), ZINC ION | 著者 | Yu, G, Wang, X, Deng, Z, Zhang, H. | 登録日 | 2022-03-09 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2022
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7VRW
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![BU of 7vrw by Molmil](/molmil-images/mine/7vrw) | VAS5 Spike (3 RBD down) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhen, C, Wang, X. | 登録日 | 2021-10-25 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | VAS5 Spike (3-RBD down) To Be Published
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8H8F
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![BU of 8h8f by Molmil](/molmil-images/mine/8h8f) | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state) | 分子名称: | Proton-activated chloride channel | 著者 | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | 登録日 | 2022-10-22 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state) To Be Published
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8H8E
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![BU of 8h8e by Molmil](/molmil-images/mine/8h8e) | Structure of the dimeric Xenopus tropical acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (closed state) | 分子名称: | Proton-activated chloride channel, tRNA (75-MER)of Spodoptera frugiperda | 著者 | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | 登録日 | 2022-10-22 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Structure of the dimeric Xenopus tropical acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (closed state) To Be Published
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8H8D
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![BU of 8h8d by Molmil](/molmil-images/mine/8h8d) | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (intermediate state) | 分子名称: | Proton-activated chloride channel | 著者 | Chi, P, Wang, X, Li, J, Li, K, Zhang, Y, Geng, J, Wu, J, Deng, D. | 登録日 | 2022-10-22 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.26 Å) | 主引用文献 | Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR trimer bound with tRNA (intermediate state) To Be Published
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7VYV
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![BU of 7vyv by Molmil](/molmil-images/mine/7vyv) | Cryo-EM structure of Depo32, a Klebsiella phage depolymerase targets the K2 serotype K. pneumoniae | 分子名称: | Depolymerase | 著者 | Cai, R, Ren, Z, Zhao, R, Wang, X, Guo, Z, Du, R, Han, W, Ru, H, Gu, J. | 登録日 | 2021-11-15 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.32 Å) | 主引用文献 | Depo32, a depolymerase of Klebsiella phage, efficiently controls infection caused by Klebsiella pneumoniae with K2 serotype CPS To Be Published
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7VZ3
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![BU of 7vz3 by Molmil](/molmil-images/mine/7vz3) | Cryo-EM structure of Depo32, a Klebsiella phage depolymerase targets the K2 serotype K. pneumoniae | 分子名称: | Depolymerase | 著者 | Cai, R, Ren, Z, Zhao, R, Wang, X, Guo, Z, Du, R, Han, W, Ru, H, Gu, J. | 登録日 | 2021-11-15 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | 主引用文献 | Depo32, a depolymerase of Klebsiella phage, efficiently controls infection caused by Klebsiella pneumoniae with K2 serotype CPS To Be Published
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8J6W
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7XD9
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![BU of 7xd9 by Molmil](/molmil-images/mine/7xd9) | Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form) | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Wu, J, Wang, X, Gong, P. | 登録日 | 2022-03-26 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
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7XD8
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![BU of 7xd8 by Molmil](/molmil-images/mine/7xd8) | Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) | 分子名称: | GLYCEROL, NS5, RNA (30-mer), ... | 著者 | Wu, J, Wang, X, Gong, P. | 登録日 | 2022-03-26 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
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7CTE
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![BU of 7cte by Molmil](/molmil-images/mine/7cte) | Human Origin Recognition Complex, ORC2-5 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ... | 著者 | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | 登録日 | 2020-08-18 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
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7CTF
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![BU of 7ctf by Molmil](/molmil-images/mine/7ctf) | Human origin recognition complex 1-5 State II | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | 著者 | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | 登録日 | 2020-08-18 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
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7D5Z
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![BU of 7d5z by Molmil](/molmil-images/mine/7d5z) | Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8 | 分子名称: | Envelope glycoprotein H, Envelope glycoprotein L, heavy chain of 1D8, ... | 著者 | Zhu, Q, Shan, S, Yu, J, Wang, X, Zhang, L, Zeng, M. | 登録日 | 2020-09-28 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | A Neutralizing Antibody Targeting a New Site of Vulnerability on Epstein-Barr Virus gH/gL Protects against Dual-Tropic Infection To Be Published
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7E3N
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![BU of 7e3n by Molmil](/molmil-images/mine/7e3n) | Crystal structure of Isocitrate dehydrogenase D252N mutant from Trypanosoma brucei in complexed with NADP+, alpha-ketoglutarate, and ca2+ | 分子名称: | CALCIUM ION, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], ... | 著者 | Arai, N, Shiba, T, Inaoka, D.K, Kita, K, Wang, X, Otani, M, Matsushiro, S, Kojima, C. | 登録日 | 2021-02-09 | 公開日 | 2022-02-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of Isocitrate dehydrogenase from Trypanosoma brucei. To Be Published
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7EB2
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![BU of 7eb2 by Molmil](/molmil-images/mine/7eb2) | Cryo-EM structure of human GABA(B) receptor-Gi protein complex | 分子名称: | (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ... | 著者 | Shen, C, Mao, C, Xu, C, Jin, N, Zhang, H, Shen, D, Shen, Q, Wang, X, Hou, T, Rondard, P, Chen, Z, Pin, J, Zhang, Y, Liu, J. | 登録日 | 2021-03-08 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of GABA B receptor-G i protein coupling. Nature, 594, 2021
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7CTG
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![BU of 7ctg by Molmil](/molmil-images/mine/7ctg) | Human Origin Recognition Complex, ORC1-5 State I | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | 著者 | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | 登録日 | 2020-08-18 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
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6QST
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![BU of 6qst by Molmil](/molmil-images/mine/6qst) | |
5VGO
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![BU of 5vgo by Molmil](/molmil-images/mine/5vgo) | Bruton's tyrosine kinase (BTK) with compound G-744 | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-(hydroxymethyl)-3-{1-methyl-6-oxo-5-[(pyrimidin-4-yl)amino]-1,6-dihydropyridin-3-yl}phenyl]-6,6-dimethyl-3,4,6,7-tetrahydro-2H-cyclopenta[4,5]thieno[2,3-c]pyridin-1(5H)-one, GLYCEROL, ... | 著者 | Yu, C, Eigenbrot, C. | 登録日 | 2017-04-11 | 公開日 | 2017-07-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.621 Å) | 主引用文献 | Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. ACS Med Chem Lett, 8, 2017
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1NP2
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8KHQ
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![BU of 8khq by Molmil](/molmil-images/mine/8khq) | Bifunctional sulfoxide synthase OvoA_Th2 in complex with histidine and cysteine | 分子名称: | 5-histidylcysteine sulfoxide synthase/putative 4-mercaptohistidine N1-methyltranferase, COBALT (II) ION, CYSTEINE, ... | 著者 | Wang, J, Ye, K, Wang, X.Y, Yan, W.P. | 登録日 | 2023-08-22 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Biochemical and Structural Characterization of OvoA Th2 : A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis. Acs Catalysis, 13, 2023
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7RT1
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![BU of 7rt1 by Molmil](/molmil-images/mine/7rt1) | Crystal Structure of KRAS G12D with compound 15 (4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol) bound | 分子名称: | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | 著者 | Gunn, R.J, Thomas, N.C, Xiaolun, W, Lawson, J.D, Marx, M.A. | 登録日 | 2021-08-12 | 公開日 | 2021-12-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | 主引用文献 | Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor. J.Med.Chem., 65, 2022
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7RT5
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![BU of 7rt5 by Molmil](/molmil-images/mine/7rt5) | Crystal structure of KRAS G12D with compound 36 (4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-ethynyl-7-fluoronaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidine) bound | 分子名称: | 4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-ethynyl-7-fluoronaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | 著者 | Gunn, R.J, Thomas, N.C, Xiaolun, W, Lawson, J.D, Marx, M.A. | 登録日 | 2021-08-12 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor. J.Med.Chem., 65, 2022
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7RT2
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![BU of 7rt2 by Molmil](/molmil-images/mine/7rt2) | Crystal Structure of KRAS G12D with compound 25 (4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol) bound | 分子名称: | 1,2-ETHANEDIOL, 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol, GLYCEROL, ... | 著者 | Gunn, R.J, Thomas, N.C, Xiaolun, W, Lawson, J.D, Marx, M.A. | 登録日 | 2021-08-12 | 公開日 | 2021-12-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor. J.Med.Chem., 65, 2022
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