5V89
| Structure of DCN4 PONY domain bound to CUL1 WHB | 分子名称: | Cullin-1, DCN1-like protein 4 | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | 登録日 | 2017-03-21 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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5V69
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5V86
| Structure of DCN1 bound to NAcM-OPT | 分子名称: | Lysozyme,DCN1-like protein 1, N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | 登録日 | 2017-03-21 | 公開日 | 2017-05-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.374 Å) | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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5VAM
| BRAF in Complex with RAF709 | 分子名称: | N-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide, Serine/threonine-protein kinase B-raf | 著者 | Mamo, M, Appleton, B.A. | 登録日 | 2017-03-27 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J. Med. Chem., 60, 2017
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5V6A
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5V83
| Structure of DCN1 bound to NAcM-HIT | 分子名称: | Lysozyme,DCN1-like protein 1 chimera, N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | 登録日 | 2017-03-21 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat. Chem. Biol., 13, 2017
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5VOE
| DesGla-XaS195A Bound to Aptamer 11F7t | 分子名称: | Aptamer 11F7t (36-MER), CALCIUM ION, Coagulation factor X, ... | 著者 | Gunaratne, R, Kumar, S, Frederiksen, J.W, Stayrook, S, Lohrmann, J.L, Perry, K, Chabata, C.V, Thalji, N.K, Ho, M.D, Arepally, G, Camire, R.M, Krishnaswamy, S.K, Sullenger, B.A. | 登録日 | 2017-05-02 | 公開日 | 2018-06-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nat. Biotechnol., 36, 2018
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5TGE
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3H5N
| Crystal structure of E. coli MccB + ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MccB protein, ... | 著者 | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | 登録日 | 2009-04-22 | 公開日 | 2009-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. Embo J., 28, 2009
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3H5R
| Crystal structure of E. coli MccB + Succinimide | 分子名称: | MccB protein, Microcin C7 analog, SULFATE ION, ... | 著者 | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | 登録日 | 2009-04-22 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. Embo J., 28, 2009
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3H9Y
| Crystal structure of the IgE-Fc3-4 domains | 分子名称: | AMMONIUM ION, Ig epsilon chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wurzburg, B.A. | 登録日 | 2009-04-30 | 公開日 | 2009-09-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. J.Mol.Biol., 393, 2009
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3H5A
| Crystal structure of E. coli MccB | 分子名称: | MccB protein, ZINC ION | 著者 | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | 登録日 | 2009-04-21 | 公開日 | 2009-06-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. Embo J., 28, 2009
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3H9Q
| Crystal structure of E. coli MccB + SeMet MccA | 分子名称: | MccB protein, Microcin C7 ANALOG, SULFATE ION, ... | 著者 | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | 登録日 | 2009-04-30 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. Embo J., 28, 2009
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3H9J
| Crystal structure of E. coli MccB + AMPCPP + SeMeT MccA | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MccB protein, Microcin C7 ANALOG, ... | 著者 | Regni, C.A, Roush, R.F, Miller, D, Nourse, A, Walsh, C.T, Schulman, B.A. | 登録日 | 2009-04-30 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic. Embo J., 28, 2009
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3H9Z
| Crystal structure of the IgE-Fc3-4 domains | 分子名称: | AMMONIUM ION, Ig epsilon chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Wurzburg, B.A. | 登録日 | 2009-04-30 | 公開日 | 2009-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. J.Mol.Biol., 393, 2009
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3HA0
| Crystal structure of the IgE-Fc3-4 domains | 分子名称: | Ig epsilon chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Wurzburg, B.A. | 登録日 | 2009-04-30 | 公開日 | 2009-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. J.Mol.Biol., 393, 2009
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3HQL
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3IVQ
| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2 | 分子名称: | CiSBC2, Speckle-type POZ protein | 著者 | Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S. | 登録日 | 2009-09-01 | 公開日 | 2009-10-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases. Mol.Cell, 36, 2009
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3IVV
| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-PucSBC1_pep1 | 分子名称: | PucSBC1, Speckle-type POZ protein | 著者 | Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S. | 登録日 | 2009-09-01 | 公開日 | 2009-10-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases. Mol.Cell, 36, 2009
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3JW0
| E2~Ubiquitin-HECT | 分子名称: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | 著者 | Kamadurai, H.B, Schulman, B.A. | 登録日 | 2009-09-17 | 公開日 | 2010-01-12 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
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3JA6
| Cryo-electron Tomography and All-atom Molecular Dynamics Simulations Reveal a Novel Kinase Conformational Switch in Bacterial Chemotaxis Signaling | 分子名称: | Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein 2 | 著者 | Cassidy, C.K, Himes, B.A, Alvarez, F.J, Ma, J, Zhao, G, Perilla, J.R, Schulten, K, Zhang, P. | 登録日 | 2015-04-21 | 公開日 | 2015-12-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (12.7 Å) | 主引用文献 | CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling. Elife, 4, 2015
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3HQM
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3JVZ
| E2~Ubiquitin-HECT | 分子名称: | E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | 著者 | Souphron, J, Kamadurai, H.B, Schulman, B.A. | 登録日 | 2009-09-17 | 公開日 | 2010-01-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
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7NSB
| Supramolecular assembly module of yeast Chelator-GID SR4 E3 ubiquitin ligase | 分子名称: | Glucose-induced degradation protein 7, Glucose-induced degradation protein 8, Vacuolar import and degradation protein 30 | 著者 | Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. | 登録日 | 2021-03-05 | 公開日 | 2021-05-05 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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7NS5
| Structure of yeast Fbp1 (Fructose-1,6-bisphosphatase 1) | 分子名称: | Fructose-1,6-bisphosphatase, MAGNESIUM ION, PHOSPHATE ION | 著者 | Sherpa, D, Chrustowicz, J, Prabu, J.R, Schulman, B.A. | 登録日 | 2021-03-05 | 公開日 | 2021-05-05 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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