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3GN9
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BU of 3gn9 by Molmil
Crystal structure of the major pseudopilin from the type 2 secretion system of Vibrio vulnificus
分子名称: CALCIUM ION, D-MALATE, Type II secretory pathway, ...
著者Korotkov, K.V, Gray, M.D, Kreger, A, Turley, S, Sandkvist, M, Hol, W.G.J.
登録日2009-03-16
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Calcium is essential for the major pseudopilin in the type 2 secretion system.
J.Biol.Chem., 284, 2009
1G3S
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BU of 1g3s by Molmil
CYS102SER DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G3Y
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BU of 1g3y by Molmil
ARG80ALA DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR, ZINC ION
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
3EIY
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BU of 3eiy by Molmil
Crystal structure of inorganic pyrophosphatase from burkholderia pseudomallei with bound pyrophosphate
分子名称: DI(HYDROXYETHYL)ETHER, Inorganic pyrophosphatase, POTASSIUM ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2008-09-17
公開日2008-09-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The role of medical structural genomics in discovering new drugs for infectious diseases.
PLoS Comput Biol, 5, 2009
6USS
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BU of 6uss by Molmil
Catalytic S88C mutant of gut microbial sulfatase from Bacteroides fragilis CAG:558
分子名称: CALCIUM ION, Sulfatase
著者Ervin, S.M, Redinbo, M.R.
登録日2019-10-28
公開日2020-11-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases.
Biochemistry, 59, 2020
6V7O
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BU of 6v7o by Molmil
Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex
分子名称: Dvl3-peptide, Kelch-like protein 12
著者Zhao, B.
登録日2019-12-09
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex.
Biochemistry, 59, 2020
1FX7
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BU of 1fx7 by Molmil
CRYSTAL STRUCTURE OF THE IRON-DEPENDENT REGULATOR (IDER) FROM MYCOBACTERIUM TUBERCULOSIS
分子名称: COBALT (II) ION, IRON-DEPENDENT REPRESSOR IDER, SULFATE ION
著者Feese, M.D, Ingason, B.P, Goranson-Siekierke, J, Holmes, R.K, Hol, W.J.G.
登録日2000-09-25
公開日2001-03-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain.
J.Biol.Chem., 276, 2001
1FWZ
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BU of 1fwz by Molmil
GLU20ALA DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR, SULFATE ION, ZINC ION
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-09-25
公開日2001-09-25
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
6UST
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BU of 6ust by Molmil
Gut microbial sulfatase from Hungatella hathewayi
分子名称: CALCIUM ION, N-acetylgalactosamine 6-sulfate sulfatase
著者Ervin, S.M, Redinbo, M.R.
登録日2019-10-28
公開日2020-11-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases.
Biochemistry, 59, 2020
1G3T
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BU of 1g3t by Molmil
CYS102SER DTXR
分子名称: DIPHTHERIA TOXIN REPRESSOR
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G3W
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BU of 1g3w by Molmil
CD-CYS102SER DTXR
分子名称: CADMIUM ION, DIPHTHERIA TOXIN REPRESSOR, SULFATE ION
著者Pohl, E, Goranson-Siekierke, J, Holmes, R.K, Hol, W.G.J.
登録日2000-10-25
公開日2001-10-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta Crystallogr.,Sect.D, 57, 2001
1G8Z
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BU of 1g8z by Molmil
HIS57ALA MUTANT OF CHOLERA TOXIN B-PENATMER
分子名称: CHOLERA TOXIN B PROTEIN, beta-D-galactopyranose
著者Aman, A.T, Fraser, S, Merritt, E.A, Rodigherio, C, Kenny, M.
登録日2000-11-21
公開日2001-07-25
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Proc.Natl.Acad.Sci.USA, 98, 2001
3I7B
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BU of 3i7b by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NM-PP1
分子名称: 1,2-ETHANEDIOL, 1-(1-methylethyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ...
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2009-07-08
公開日2010-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.988 Å)
主引用文献Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nat.Struct.Mol.Biol., 17, 2010
3I7C
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BU of 3i7c by Molmil
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumped kinase inhibitor NA-PP2
分子名称: 1-tert-butyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2009-07-08
公開日2010-02-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nat.Struct.Mol.Biol., 17, 2010
3IBE
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BU of 3ibe by Molmil
Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma
分子名称: 1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Bard, J, Svenson, K.
登録日2009-07-15
公開日2009-09-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.798 Å)
主引用文献ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin: Design and Synthesis of Highly Potent and Selective Pyrazolopyrimidines.
J.Med.Chem., 52, 2009
3CVL
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BU of 3cvl by Molmil
Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide
分子名称: Peroxisome targeting signal 1 receptor PEX5, T. brucei PFK PTS1 peptide Ac-HEELAKL
著者Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J.
登録日2008-04-18
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVQ
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BU of 3cvq by Molmil
Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to PTS1 peptide (7-SKL)
分子名称: GLYCEROL, PTS1 peptide 7-SKL (Ac-SNRWSKL), Peroxisome targeting signal 1 receptor PEX5
著者Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J.
登録日2008-04-18
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
6VPG
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BU of 6vpg by Molmil
TPX2 residues 7-20 fused to Aurora A residues 116-389 in complex with AMP-PNP
分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ...
著者Lim, D.C, Yaffe, M.B.
登録日2020-02-03
公開日2020-08-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Redox priming promotes Aurora A activation during mitosis.
Sci.Signal., 13, 2020
6VPM
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BU of 6vpm by Molmil
TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 8-34, and in complex with AMP-PNP
分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, MALONIC ACID, ...
著者Lim, D.C, Yaffe, M.B.
登録日2020-02-03
公開日2020-08-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Redox priming promotes Aurora A activation during mitosis.
Sci.Signal., 13, 2020
6VPI
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BU of 6vpi by Molmil
TPX2 residues 7-20 fused to Aurora A residues 116-389 C247V + D256N + C319V triple mutant disulfide homodimer in complex with AMP-PNP
分子名称: MAGNESIUM ION, MALONIC ACID, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Lim, D.C, Yaffe, M.B.
登録日2020-02-03
公開日2020-08-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Redox priming promotes Aurora A activation during mitosis.
Sci.Signal., 13, 2020
6VPL
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BU of 6vpl by Molmil
TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 7-80, and in complex with AMP-PNP
分子名称: GLYCEROL, MAGNESIUM ION, MALONIC ACID, ...
著者Lim, D.C, Yaffe, M.B.
登録日2020-02-03
公開日2020-08-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Redox priming promotes Aurora A activation during mitosis.
Sci.Signal., 13, 2020
3I7F
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BU of 3i7f by Molmil
Aspartyl tRNA synthetase from Entamoeba histolytica
分子名称: Aspartyl-tRNA synthetase
著者Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2009-07-08
公開日2009-07-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Mol.Biochem.Parasitol., 169, 2010
6VMT
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BU of 6vmt by Molmil
Leishmania major Programmed Cell Death Protein 5 Homolog
分子名称: Programmed Cell Death Protein 5 Homolog
著者Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2020-01-28
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Leishmania major Programmed Cell Death Protein 5 Homolog
To be published
3IAL
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BU of 3ial by Molmil
Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate
分子名称: 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL, Prolyl-tRNA synthetase
著者Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
登録日2009-07-14
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr.,Sect.D, 68, 2012
1GYQ
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CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
分子名称: N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE)
著者Suresh, S, Hol, W.
登録日1999-03-05
公開日1999-03-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 96, 1999

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