Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6JGX
DownloadVisualize
BU of 6jgx by Molmil
Crystal structure of the transcriptional regulator CadR from P. putida in complex with Cadmium(II) and DNA
分子名称: CADMIUM ION, CadR, DNA (5'-D(*CP*AP*CP*CP*CP*TP*AP*TP*AP*GP*TP*GP*GP*CP*TP*AP*CP*AP*GP*GP*GP*T)-3'), ...
著者Liu, X.C, Gan, J.H, Chen, H.
登録日2019-02-15
公開日2019-09-25
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
6K1H
DownloadVisualize
BU of 6k1h by Molmil
Structure of membrane protein
分子名称: PTS mannose transporter subunit IID, PTS system mannose-specific EIIC component, alpha-D-mannopyranose
著者Wang, J.W, Zeng, J.W.
登録日2019-05-10
公開日2019-07-10
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structure of the mannose transporter of the bacterial phosphotransferase system.
Cell Res., 29, 2019
7W26
DownloadVisualize
BU of 7w26 by Molmil
monolignol ferulate transferase
分子名称: Ferulate monolignol transferase
著者Xi, L, Shuliu, D, Yue, F, Yi, Z.
登録日2021-11-22
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Crystal structure of the plant feruloyl-coenzyme A monolignol transferase provides insights into the formation of monolignol ferulate conjugates.
Biochem.Biophys.Res.Commun., 594, 2022
7WUA
DownloadVisualize
BU of 7wua by Molmil
Crystal structures of FadD32 from Corynebacterium diphtheriae
分子名称: Acyl-CoA synthase, MAGNESIUM ION, MYRISTIC ACID, ...
著者Liu, X.
登録日2022-02-07
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.999 Å)
主引用文献Crystal structures of FadD32 and pks13-ACP domain from Corynebacterium diphtheriae
Biochem Biophys Res Commun, 590, 2022
7ECV
DownloadVisualize
BU of 7ecv by Molmil
The Csy-AcrIF14 complex
分子名称: AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ...
著者Zhang, L.X, Feng, Y.
登録日2021-03-13
公開日2021-11-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
7DU0
DownloadVisualize
BU of 7du0 by Molmil
Structure of an type I-F anti-crispr protein
分子名称: AcrIF14
著者Teng, G, Yue, F.
登録日2021-01-07
公開日2021-11-17
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
7ECW
DownloadVisualize
BU of 7ecw by Molmil
The Csy-AcrIF14-dsDNA complex
分子名称: 54-MER DNA, AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, ...
著者Zhang, L.X, Feng, Y.
登録日2021-03-13
公開日2021-11-17
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
7XSQ
DownloadVisualize
BU of 7xsq by Molmil
Structure of the Craspase
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zhang, L.
登録日2022-05-15
公開日2022-11-09
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XSP
DownloadVisualize
BU of 7xsp by Molmil
Structure of gRAMP-target RNA
分子名称: RAMP superfamily protein, RNA (35-MER), RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3'), ...
著者Feng, Y, Zhang, L.X.
登録日2022-05-15
公開日2022-11-09
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XT4
DownloadVisualize
BU of 7xt4 by Molmil
Structure of Craspase-NTR
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zhang, L.
登録日2022-05-16
公開日2022-11-09
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XSR
DownloadVisualize
BU of 7xsr by Molmil
Structure of Craspase-target RNA
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zhang, L.
登録日2022-05-15
公開日2022-11-09
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XSS
DownloadVisualize
BU of 7xss by Molmil
Structure of Craspase-CTR
分子名称: CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ...
著者Feng, Y, Zang, L.X.
登録日2022-05-15
公開日2022-11-09
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
7XSO
DownloadVisualize
BU of 7xso by Molmil
Structure of the type III-E CRISPR-Cas effector gRAMP
分子名称: RAMP superfamily protein, RNA (35-MER), ZINC ION
著者Feng, Y, Zhang, L.
登録日2022-05-15
公開日2023-03-22
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
1MKS
DownloadVisualize
BU of 1mks by Molmil
CARBOXYLIC ESTER HYDROLASE, TRIGONAL FORM OF THE TRIPLE MUTANT
分子名称: CALCIUM ION, PHOSPHOLIPASE A2
著者Sundaralingam, M.
登録日1997-08-27
公開日1997-12-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.
Biochemistry, 36, 1997
6DQ4
DownloadVisualize
BU of 6dq4 by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR GSK-J1
分子名称: 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Horton, J.R, Cheng, X.
登録日2018-06-10
公開日2018-11-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.392 Å)
主引用文献Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
J. Med. Chem., 61, 2018
6DQ9
DownloadVisualize
BU of 6dq9 by Molmil
Linked KDM5A JMJ Domain Bound to the Covalent Inhibitor N69 i.e. [2-((3-acrylamidophenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid]
分子名称: 1,2-ETHANEDIOL, 2-{(R)-[3-(acryloylamino)phenyl][2-(piperidin-1-yl)ethoxy]methyl}thieno[3,2-b]pyridine-7-carboxylic acid, DIMETHYL SULFOXIDE, ...
著者Horton, J.R, Cheng, X.
登録日2018-06-10
公開日2018-11-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.748 Å)
主引用文献Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
J. Med. Chem., 61, 2018
6DQ5
DownloadVisualize
BU of 6dq5 by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N43 i.e. 3-((6-(4-acryloyl-1,4-diazepan-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid
分子名称: Linked KDM5A Jmj Domain, MANGANESE (II) ION, N-[6-(4-acryloyl-1,4-diazepan-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl]-beta-alanine
著者Horton, J.R, Cheng, X.
登録日2018-06-10
公開日2018-11-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
J. Med. Chem., 61, 2018
6DQ7
DownloadVisualize
BU of 6dq7 by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE POTENTIAL HYDROLYSIS PRODUCT OF INHIBITOR N45 i.e. 3-((6-(4-(2-cyano-3-methylbut-2-enoyl)-1,4-diazepan-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Linked KDM5A Jmj Domain, ...
著者Horton, J.R, Cheng, X.
登録日2018-06-10
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structure-based Engineering of Reversible Covalent Inhibitors Against Histone Lysine Demethylase 5A
To Be Published
6DQE
DownloadVisualize
BU of 6dqe by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N67 i.e. 2-(5-phenyl-4-(phenyl(2-(piperidin-1-yl)ethoxy)methyl)-1H-pyrazol-1-yl)isonicotinic acid
分子名称: 2-(5-phenyl-4-{(R)-phenyl[2-(piperidin-1-yl)ethoxy]methyl}-1H-pyrazol-1-yl)pyridine-4-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Horton, J.R, Cheng, X.
登録日2018-06-10
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.689 Å)
主引用文献To be determined
To Be Published
6DQD
DownloadVisualize
BU of 6dqd by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N53 i.e. 2-(5-([1,1'-biphenyl]-3-yl)-4-(1-(2-(piperidin-1-yl)ethoxy)ethyl)-1H-pyrazol-1-yl)isonicotinic acid
分子名称: 2-[5-([1,1'-biphenyl]-3-yl)-4-{(1S)-1-[2-(piperidin-1-yl)ethoxy]ethyl}-1H-pyrazol-1-yl]pyridine-4-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Horton, J.R, Cheng, X.
登録日2018-06-10
公開日2019-06-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.987 Å)
主引用文献To be determined
To Be Published
6R9G
DownloadVisualize
BU of 6r9g by Molmil
Structural basis of transcription inhibition by the DNA mimic Ocr protein of bacteriophage T7
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Ye, F.Z, Zhang, X.D.
登録日2019-04-03
公開日2020-02-26
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7.
Elife, 9, 2020
5IVE
DownloadVisualize
BU of 5ive by Molmil
Linked KDM5A Jmj Domain Bound to the Inhibitor N8 ( 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile)
分子名称: 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, Lysine-specific demethylase 5A, MANGANESE (II) ION
著者Horton, J.R, Cheng, X.
登録日2016-03-20
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.783 Å)
主引用文献Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
Cell Chem Biol, 23, 2016
5IW0
DownloadVisualize
BU of 5iw0 by Molmil
Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-chloro-2-methylbenzyl)oxy)-1H-pyrazol-1-yl)isonicotinic acid]
分子名称: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 2-{5-[(4-chloro-2-methylphenyl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carboxylic acid, ...
著者Horton, J.R, Cheng, X.
登録日2016-03-21
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
Cell Chem Biol, 23, 2016
7YW5
DownloadVisualize
BU of 7yw5 by Molmil
Crystal Structure of the ITS1 processing by human ribonuclease ISG20L2 with mutation D327A
分子名称: Interferon-stimulated 20 kDa exonuclease-like 2
著者Yang, X.Y, Liu, X.H.
登録日2022-08-21
公開日2024-01-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Molecular mechanism of human ISG20L2 for the ITS1 cleavage in the processing of 18S precursor ribosomal RNA.
Nucleic Acids Res., 52, 2024
5J87
DownloadVisualize
BU of 5j87 by Molmil
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
分子名称: N-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide, Tyrosine-protein kinase BTK
著者Yun, C.H, Zhang, S.
登録日2016-04-07
公開日2017-04-19
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor.
Eur J Med Chem, 131, 2017

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon