6M20
 
 | | Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose | | 分子名称: | Hexose transporter 1, beta-D-glucopyranose, nonyl beta-D-glucopyranoside | | 著者 | Jiang, X, Yuan, Y.Y, Zhang, S, Wang, N, Yan, C.Y, Yan, N. | | 登録日 | 2020-02-26 | | 公開日 | 2020-09-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.
Cell, 183, 2020
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6Z2Z
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6Z2U
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6M71
 | | SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors | | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase | | 著者 | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | | 登録日 | 2020-03-16 | | 公開日 | 2020-04-01 | | 最終更新日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
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6ZSX
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6ZSW
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8D4Z
 | | Crystal structure of USP7 in complex with allosteric inhibitor FX1-3763 | | 分子名称: | 1-({(7M)-7-[1-(azetidin-3-yl)-6-chloro-1,2,3,4-tetrahydroquinolin-8-yl]thieno[3,2-b]pyridin-2-yl}methyl)pyrrolidine-2,5-dione, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Bell, J.A. | | 登録日 | 2022-06-03 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Novel USP7 inhibitors demonstrate potent anti-cancer activity in models of AML, synergy with BCL2 inhibition, and a differentiated mechanism of action
To Be Published
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8IYX
 | | Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365 | | 分子名称: | 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365 | | 著者 | Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M. | | 登録日 | 2023-04-06 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8IPT
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8IPS
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8IPQ
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7BW6
 | | Varicella-zoster virus capsid | | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | | 著者 | Wang, P.Y, Qi, J.X, Liu, C.C, Sun, J.Q. | | 登録日 | 2020-04-13 | | 公開日 | 2020-09-23 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the varicella-zoster virus A-capsid.
Nat Commun, 11, 2020
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8IPR
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4QQG
 | | Crystal structure of an N-terminal HTATIP fragment | | 分子名称: | Histone acetyltransferase KAT5, UNKNOWN ATOM OR ION | | 著者 | Liu, Y, Tempel, W, Wernimont, A.K, Dobrovetsky, E, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2014-06-27 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and histone binding studies of the chromo barrel domain of TIP60.
FEBS Lett., 592, 2018
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6OAP
 | | Crystal structure of a dual sensor histidine kinase in the green-light absorbing Pg state | | 分子名称: | Dual sensor histidine kinase, MAGNESIUM ION, PHYCOCYANOBILIN | | 著者 | Heewhan, S, Zhong, R, Xiaoli, Z, Sepalika, B, Xiaojing, Y. | | 登録日 | 2019-03-18 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural basis of molecular logic OR in a dual-sensor histidine kinase.
Proc.Natl.Acad.Sci.USA, 116, 2019
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1UP7
 | | Structure of the 6-phospho-beta glucosidase from Thermotoga maritima at 2.4 Angstrom resolution in the tetragonal form with NAD and glucose-6-phosphate | | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, 6-PHOSPHO-BETA-GLUCOSIDASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Varrot, A, Yip, V.L, Withers, S.G, Davies, G.J. | | 登録日 | 2003-09-29 | | 公開日 | 2004-11-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Nad+ and Metal-Ion Dependent Hydrolysis by Family 4 Glycosidases: Structural Insight Into Specificity for Phospho-Beta-D-Glucosides
J.Mol.Biol., 346, 2005
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1UP6
 | | Structure of the 6-phospho-beta glucosidase from Thermotoga maritima at 2.55 Angstrom resolution in the tetragonal form with manganese, NAD+ and glucose-6-phosphate | | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, 6-PHOSPHO-BETA-GLUCOSIDASE, MANGANESE (II) ION, ... | | 著者 | Varrot, A, Yip, V.L, Withers, S.G, Davies, G.J. | | 登録日 | 2003-09-29 | | 公開日 | 2004-08-02 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | An Unusual Mechanism of Glycoside Hydrolysis Involving Redox and Elimination Steps by a Family 4 Beta-Glycosidase from Thermotoga Maritima.
J.Am.Chem.Soc., 126, 2004
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1UP4
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7Q0Q
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7Q1X
 | | Acetyltrasferase(3) type IIIa in complex with neomycin B | | 分子名称: | Aminoglycoside N(3)-acetyltransferase III, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pontillo, N, Guskov, A. | | 登録日 | 2021-10-21 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | The 3-N-alkylation of the neomycin B outmaneuvers the aminoglycoside resistant enzyme acetyltransferase(3)IIIa via an unexpected mechanism
To Be Published
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7Q10
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7Q1D
 | | Acetyltrasferase(3) type IIIa in complex with 3-N-methyl-nemycin B | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aminoglycoside N(3)-acetyltransferase III, CHLORIDE ION, ... | | 著者 | Pontillo, N, Guskov, A. | | 登録日 | 2021-10-18 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | 3-N-alkylation in aminoglycoside antibiotic neomycin B overcomes bacterial resistance mediated by acetyltransferase (3) IIIa
To Be Published
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8HVR
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3V86
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3UO8
 | | Crystal structure of the MALT1 paracaspase (P1 form) | | 分子名称: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | | 著者 | Jeffrey, P.D, Yu, J.W, Shi, Y. | | 登録日 | 2011-11-16 | | 公開日 | 2011-12-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.
Proc.Natl.Acad.Sci.USA, 108, 2011
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