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2WYQ
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BU of 2wyq by Molmil
THE CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE (UBL) DOMAIN OF HHR23A (HUMAN HOMOLOGUE A OF RAD23)
分子名称: SULFATE ION, UV EXCISION REPAIR PROTEIN RAD23 HOMOLOG A
著者Chen, Y.W.
登録日2009-11-19
公開日2010-11-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献The Crystal Structure of the Ubiquitin-Like (Ubl) Domain of Human Homologue a of Rad23 (Hhr23A) Protein
Protein Eng.Des.Sel., 24, 2011
4I1L
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BU of 4i1l by Molmil
Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function
分子名称: ACETATE ION, Forkhead box protein P3, MAGNESIUM ION, ...
著者Song, X.M, Greene, M.I, Zhou, Z.C.
登録日2012-11-21
公開日2012-12-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.
Cell Rep, 1, 2012
4IOP
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BU of 4iop by Molmil
Crystal structure of NKp65 bound to its ligand KACL
分子名称: C-type lectin domain family 2 member A, Killer cell lectin-like receptor subfamily F member 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Li, Y.
登録日2013-01-08
公開日2013-07-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex.
Proc.Natl.Acad.Sci.USA, 110, 2013
7CHH
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BU of 7chh by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with BD-368-2 Fabs
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BD-368-2 Fab heavy chain, ...
著者Xiao, J, Zhu, Q, Wang, G.
登録日2020-07-05
公開日2020-09-16
最終更新日2020-11-25
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Cell, 183, 2020
8JJO
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BU of 8jjo by Molmil
Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist
分子名称: (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562
著者He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y.
登録日2023-05-31
公開日2023-09-06
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
8J7E
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BU of 8j7e by Molmil
Crystal structure of BRIL in complex with 1b3 Fab
分子名称: Antibody 1b3 Fab Heavy chain, Antibody 1b3 Fab Light chain, Soluble cytochrome b562
著者Zhong, Y.X, Guo, Q, Tao, Y.Y.
登録日2023-04-27
公開日2023-09-06
最終更新日2024-01-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
8JJL
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BU of 8jjl by Molmil
cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist
分子名称: Beta-2 adrenergic receptor,Soluble cytochrome b562, Olodaterol
著者He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y.
登録日2023-05-30
公開日2023-09-06
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
8JJ8
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BU of 8jj8 by Molmil
Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist
分子名称: Beta-2 adrenergic receptor,Soluble cytochrome b562, ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide
著者He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y.
登録日2023-05-29
公開日2023-09-06
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
8JMT
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BU of 8jmt by Molmil
Structure of the adhesion GPCR ADGRL3 in the apo state
分子名称: Adhesion G protein-coupled receptor L3,Soluble cytochrome b562
著者Tao, Y, Guo, Q, He, B, Zhong, Y.
登録日2023-06-05
公開日2023-09-06
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
6A50
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BU of 6a50 by Molmil
structure of benzoylformate decarboxylases in complex with cofactor TPP
分子名称: MAGNESIUM ION, THIAMINE DIPHOSPHATE, benzoylformate decarboxylases
著者Guo, Y, Wang, S, Nie, Y, Li, S.
登録日2018-06-21
公開日2019-02-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Synthetic Pathway for Acetyl-Coenzyme A Biosynthesis
Nat Commun, 2019
7CHF
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BU of 7chf by Molmil
Crystal structure of the SARS-CoV-2 RBD in complex with BD-604 Fab and BD-368-2 Fab
分子名称: BD-368-2 Fab heavy chain, BD-368-2 Fab light chain, BD-604 Fab heavy chain, ...
著者Xiao, J, Zhu, Q.
登録日2020-07-05
公開日2020-09-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.674 Å)
主引用文献Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Cell, 183, 2020
7CHB
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BU of 7chb by Molmil
Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BD-236 Fab heavy chain, BD-236 Fab light chain, ...
著者Xiao, J, Zhu, Q.
登録日2020-07-05
公開日2020-09-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Cell, 183, 2020
7CHE
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BU of 7che by Molmil
Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab and BD-368-2 Fab
分子名称: BD-236 Fab heavy chain, BD-236 Fab light chain, BD-368-2 Fab heavy chain, ...
著者Xiao, J, Zhu, Q.
登録日2020-07-05
公開日2020-09-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.416 Å)
主引用文献Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Cell, 183, 2020
7CHC
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BU of 7chc by Molmil
Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab and BD-368-2 Fab
分子名称: BD-368-2 Fab H, BD-368-2 Fab L, BD-629 Fab H, ...
著者Du, S, Xiao, J.Y.
登録日2020-07-05
公開日2020-09-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
Cell, 183, 2020
8SNX
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BU of 8snx by Molmil
Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoter
分子名称: Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*GP*CP*GP*U)-3'), RNA-directed RNA polymerase L
著者Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B.
登録日2023-04-28
公開日2023-12-20
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
8SNY
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BU of 8sny by Molmil
Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter
分子名称: Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*UP*CP*GP*U)-3'), RNA-directed RNA polymerase L
著者Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B.
登録日2023-04-28
公開日2023-12-20
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
6J4R
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BU of 6j4r by Molmil
Structural basis for the target DNA recognition and binding by the MYB domain of phosphate starvation response regulator 1
分子名称: DNA (5'-D(*CP*AP*GP*TP*AP*TP*AP*TP*AP*CP*C)-3'), DNA (5'-D(*CP*CP*AP*TP*AP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*TP*AP*TP*AP*CP*TP*G)-3'), ...
著者Jiang, M.Q, Sun, L.F, Isupov, M.N.
登録日2019-01-10
公開日2019-04-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1.
Febs J., 286, 2019
6J4K
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BU of 6j4k by Molmil
Structural basis for the target DNA recognition and binding by the MYB domain of phosphate starvation response 1
分子名称: GLYCEROL, MALONIC ACID, Protein PHOSPHATE STARVATION RESPONSE 1
著者Jiang, M.Q, Sun, L.F.
登録日2019-01-09
公開日2019-04-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1.
Febs J., 286, 2019
6J5B
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BU of 6j5b by Molmil
Structural basis for the target DNA recognition and binding by the MYB domain of phosphate starvation response regulator 1
分子名称: DNA (5'-D(*GP*GP*TP*AP*CP*AP*GP*TP*AP*TP*AP*TP*AP*CP*CP*AP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*GP*GP*TP*AP*TP*AP*TP*AP*CP*TP*GP*TP*AP*CP*C)-3'), Protein PHOSPHATE STARVATION RESPONSE 1
著者Jiang, M.Q, Sun, L.F, Isupov, M.N, Wu, Y.K.
登録日2019-01-10
公開日2019-04-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1.
Febs J., 286, 2019
8TSA
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BU of 8tsa by Molmil
Human PI3K p85alpha/p110alpha H1047R bound to compound 2
分子名称: 5-(3-bromo-5-fluorobenzamido)-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J, Valverde, R.
登録日2023-08-11
公開日2023-11-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
8TS8
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BU of 8ts8 by Molmil
p85alpha/p110alpha heterodimer H1047R mutant
分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J.
登録日2023-08-11
公開日2023-11-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
8TS7
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BU of 8ts7 by Molmil
Human PI3K p85alpha/p110alpha
分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J.
登録日2023-08-11
公開日2023-11-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
8TSB
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BU of 8tsb by Molmil
Human PI3K p85alpha/p110alpha bound to compound 2
分子名称: 5-(3-bromo-5-fluorobenzamido)-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J.
登録日2023-08-11
公開日2023-11-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
8TSC
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BU of 8tsc by Molmil
Human PI3K p85alpha/p110alpha H1047R bound to compound 3
分子名称: (1S)-7-[3-fluoro-5-(trifluoromethyl)benzamido]-N-methyl-1-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-isoindole-5-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J.
登録日2023-08-11
公開日2023-11-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
8TS9
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BU of 8ts9 by Molmil
Human PI3K p85alpha/p110alpha H1047R bound to compound 1
分子名称: 5-[3-fluoro-5-(trifluoromethyl)benzamido]-N-methyl-6-(2-methylanilino)pyridine-3-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J.
登録日2023-08-11
公開日2023-11-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024

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