5L8M
 
 | | Wild-type PAS-GAF fragment from Deinococcus radiodurans Bphp collected at LCLS | | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, ACETATE ION, Bacteriophytochrome | | 著者 | Claesson, E, Takala, H, Edlund, P, Henry, L, Dods, R, Schmidt, M, Westenhoff, S. | | 登録日 | 2016-06-08 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography.
Sci Rep, 6, 2016
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5ZQP
 | | Tankyrase-2 in complex with compound 12 | | 分子名称: | 1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)-2H-spiro[1-benzofuran-3,4'-piperidin]-2-one, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2018-04-19 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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5ZQR
 | | Tankyrase-2 in complex with compound 40c | | 分子名称: | 2-[4,6-difluoro-1-(2-hydroxyethyl)-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2018-04-19 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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6A84
 | | Tankyrase-2 in complex with compound 15d | | 分子名称: | 2-(4-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | 登録日 | 2018-07-06 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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3VHV
 | | Mineralocorticoid receptor ligand-binding domain with non-steroidal antagonist | | 分子名称: | 1,2-ETHANEDIOL, 6-[(1E)-2-phenyl-N-(3-sulfanyl-4H-1,2,4-triazol-4-yl)ethanimidoyl]-2H-1,4-benzoxazin-3(4H)-one, 6-[(7S)-7-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-2H-1,4-benzoxazin-3(4H)-one, ... | | 著者 | Sogabe, S, Habuka, N. | | 登録日 | 2011-09-07 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists
J.Med.Chem., 54, 2011
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6LYC
 | | Crystal structure of the NOD SIRPa complex with D4-2 | | 分子名称: | ACETIC ACID, D4-2, SIRPa of the NOD mouse strain | | 著者 | Murata, Y, Matsuda, M, Nakagawa, A, Matozaki, T. | | 登録日 | 2020-02-14 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Macrocyclic Peptide-Mediated Blockade of the CD47-SIRP alpha Interaction as a Potential Cancer Immunotherapy.
Cell Chem Biol, 27, 2020
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3VHU
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5EXV
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6Y7A
 | | X-ray structure of the Haloalkane dehalogenase HaloTag7 labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate | | 分子名称: | CHLORIDE ION, GLYCEROL, Haloalkane dehalogenase, ... | | 著者 | Tarnawski, M, Johnsson, K, Hiblot, J. | | 登録日 | 2020-02-28 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag.
Biochemistry, 60, 2021
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6Y7B
 | | X-ray structure of the Haloalkane dehalogenase HaloTag7 labeled with a chloroalkane-carbopyronine fluorophore substrate | | 分子名称: | 4-[2-[2-(6-chloranylhexoxy)ethoxy]ethylcarbamoyl]-2-[3-(dimethylamino)-6-(dimethyl-$l^{4}-azanylidene)-10,10-dimethyl-anthracen-9-yl]benzoic acid, CHLORIDE ION, Haloalkane dehalogenase | | 著者 | Tarnawski, M, Johnsson, K, Hiblot, J. | | 登録日 | 2020-02-28 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag.
Biochemistry, 60, 2021
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6QA7
 | | Glycogen Phosphorylase b in complex with 29 | | 分子名称: | (5~{S},7~{R},8~{S},9~{S},10~{R})-7-(hydroxymethyl)-2-naphthalen-1-yl-8,9,10-tris(oxidanyl)-6-oxa-1,3-diazaspiro[4.5]dec-1-en-4-one, Glycogen phosphorylase, muscle form, ... | | 著者 | Kyriakis, E, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2018-12-18 | | 公開日 | 2019-06-26 | | 最終更新日 | 2019-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
J.Med.Chem., 62, 2019
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1ETN
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6QA6
 | | Glycogen Phosphorylase b in complex with 30 | | 分子名称: | (5~{S},7~{R},8~{S},9~{S},10~{R})-7-(hydroxymethyl)-2-naphthalen-2-yl-8,9,10-tris(oxidanyl)-6-oxa-1,3-diazaspiro[4.5]dec-1-en-4-one, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | | 著者 | Kyriakis, E, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2018-12-18 | | 公開日 | 2019-06-26 | | 最終更新日 | 2019-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
J.Med.Chem., 62, 2019
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8I2Z
 | | Cryo-EM structure of the zeaxanthin-bound kin4B8 | | 分子名称: | RETINAL, Xanthorhodopsin, Zeaxanthin | | 著者 | Murakoshi, S, Chazan, A, Shihoya, W, Beja, O, Nureki, O. | | 登録日 | 2023-01-15 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2 Å) | | 主引用文献 | Phototrophy by antenna-containing rhodopsin pumps in aquatic environments.
Nature, 615, 2023
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6QA8
 | | Glycogen Phosphorylase b in complex with 28 | | 分子名称: | (5~{S},7~{R},8~{S},9~{S},10~{R})-7-(hydroxymethyl)-8,9,10-tris(oxidanyl)-2-phenyl-6-oxa-1,3-diazaspiro[4.5]dec-1-en-4-one, Glycogen phosphorylase, muscle form, ... | | 著者 | Kyriakis, E, Stravodimos, G.A, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2018-12-18 | | 公開日 | 2019-06-26 | | 最終更新日 | 2019-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
J.Med.Chem., 62, 2019
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6ZCC
 | | X-ray structure of the Haloalkane dehalogenase HOB (HaloTag7-based Oligonucleotide Binder) labeled with a chloroalkane-tetramethylrhodamine fluorophore substrate | | 分子名称: | ACETATE ION, CALCIUM ION, Haloalkane dehalogenase, ... | | 著者 | Tarnawski, M, Johnsson, K, Hiblot, J. | | 登録日 | 2020-06-10 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag.
Biochemistry, 60, 2021
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5GKR
 | | Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide | | 分子名称: | DNA (5'-D(P*TP*TP*TP*T)-3'), IgG2, Fab (heavy chain), ... | | 著者 | Arimori, T, Sakakibara, S, Kikutani, H, Takagi, J. | | 登録日 | 2016-07-05 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus
Sci Rep, 7, 2017
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5URM
 | | Crystal structure of human BRR2 in complex with T-1206548 | | 分子名称: | 3-(5-{[(2R)-5-amino-2-cyclohexyl-7-oxo-2,3-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl]methyl}furan-2-yl)benzoic acid, U5 small nuclear ribonucleoprotein 200 kDa helicase | | 著者 | Klein, M.G, Tjhen, R, Qin, L. | | 登録日 | 2017-02-11 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
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5URJ
 | | Crystal structure of human BRR2 in complex with T-3905516 | | 分子名称: | 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase | | 著者 | Klein, M.G, Tjhen, R, Qin, L. | | 登録日 | 2017-02-10 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
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5URK
 | | Crystal structure of human BRR2 in complex with T-3935799 | | 分子名称: | 6-benzyl-3-[3-(benzyloxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione, GLYCEROL, U5 small nuclear ribonucleoprotein 200 kDa helicase | | 著者 | Qin, L, Tjhen, R, Klein, M.G. | | 登録日 | 2017-02-10 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
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3KC6
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5GKS
 | | Crystal structure of SLE patient-derived anti-DNA antibody | | 分子名称: | IgG2, Fab (heavy chain), PHOSPHATE ION, ... | | 著者 | Arimori, T, Sakakibara, S, Kikutani, H, Takagi, J. | | 登録日 | 2016-07-05 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus
Sci Rep, 7, 2017
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3KHW
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2D7G
 | | Crystal structure of the aa complex of the N-terminal domain of PriA | | 分子名称: | DNA (5'-D(P*AP*A)-3'), Primosomal protein N' | | 著者 | Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D. | | 登録日 | 2005-11-21 | | 公開日 | 2006-11-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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7VGU
 | | Time-resolved serial femtosecond crystallography structure of light-driven chloride ion-pumping rhodopsin, NM-R3 : structure obtained 1 msec after photoexcitation with bromide ion | | 分子名称: | BROMIDE ION, Chloride pumping rhodopsin, DECANE, ... | | 著者 | Hosaka, T, Nango, E, Nakane, T, Luo, F, Kimura-Someya, T, Shirouzu, M. | | 登録日 | 2021-09-18 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers.
Proc.Natl.Acad.Sci.USA, 119, 2022
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