7TPR
| Camel nanobodies 7A3 and 8A2 broadly neutralize SARS-CoV-2 variants | 分子名称: | Nanobody 7A3, Nanobody 8A2, Spike glycoprotein | 著者 | Butay, K.J, Zhu, J, Dandey, V.P, Hong, J, Kwon, H.J, Chen, C.Z, Duan, Z, Li, D, Ren, H, Liang, T, Martin, N, Esposito, D, Ortega-Rodriguez, U, Xu, M, Xie, H, Ho, M, Cachau, R, Borgnia, M.J. | 登録日 | 2022-01-25 | 公開日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | 主引用文献 | Camel nanobodies broadly neutralize SARS-CoV-2 variants bioRxiv, 2021
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7OFF
| Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction | 分子名称: | (2~{R})-2-[(9-oxidanylidenefluoren-4-yl)carbonylamino]-2-phenyl-ethanoic acid, DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, ... | 著者 | Narayanan, D, Bach, A, Gajhede, M. | 登録日 | 2021-05-04 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65, 2022
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7OFE
| Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction | 分子名称: | 2-[(9-oxidanylidenefluoren-4-yl)carbonylamino]ethanoic acid, DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, ... | 著者 | Narayanan, D, Bach, A, Gajhede, M. | 登録日 | 2021-05-04 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65, 2022
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7OFC
| Keap1 kelch domain bound to a small molecule fragment | 分子名称: | DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, SULFATE ION, ... | 著者 | Narayanan, D, Bach, A, Gajhede, M. | 登録日 | 2021-05-04 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65, 2022
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1TS0
| Structure of the pB1 intermediate from time-resolved Laue crystallography | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | 著者 | Ihee, H, Rajagopal, S, Srajer, V, Pahl, R, Anderson, S, Schmidt, M, Schotte, F, Anfinrud, P.A, Wulff, M, Moffat, K. | 登録日 | 2004-06-21 | 公開日 | 2005-07-05 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. Proc.Natl.Acad.Sci.Usa, 102, 2005
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7OFB
| Keap1 kelch domain bound to a small molecule fragment | 分子名称: | DIMETHYL SULFOXIDE, Kelch-like ECH-associated protein 1, SULFATE ION, ... | 著者 | Narayanan, D, Bach, A, Gajhede, M. | 登録日 | 2021-05-04 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65, 2022
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7OF8
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4N0S
| Complex of ERK2 with caffeic acid | 分子名称: | CAFFEIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Kurinov, I, Malakhova, M. | 登録日 | 2013-10-02 | 公開日 | 2014-08-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7992 Å) | 主引用文献 | Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis. Cancer Prev Res (Phila), 7, 2014
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7TRJ
| The eukaryotic translation initiation factor 2B from Homo sapiens with a H160D mutation in the beta subunit | 分子名称: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | 著者 | Wang, L, Schoof, M, Lawrence, R, Boone, M, Frost, A, Walter, P. | 登録日 | 2022-01-29 | 公開日 | 2022-04-27 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. Elife, 11, 2022
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1K9V
| Structural evidence for ammonia tunelling across the (beta-alpha)8-barrel of the imidazole glycerol phosphate synthase bienzyme complex | 分子名称: | ACETIC ACID, Amidotransferase hisH | 著者 | Douangamath, A, Walker, M, Beismann-Driemeyer, S, Vega-Fernandez, M.C, Sterner, R, Wilmanns, M. | 登録日 | 2001-10-31 | 公開日 | 2002-02-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex. Structure, 10, 2002
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6P9G
| Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid | 分子名称: | (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 5, ... | 著者 | Tempel, W, Mann, M.K, Harding, R.J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Schapira, M, Structural Genomics Consortium (SGC) | 登録日 | 2019-06-10 | 公開日 | 2019-09-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J.Med.Chem., 62, 2019
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7TJ0
| Crystal structure of SARS-CoV-2 3CL in complex with inhibitor SL-4-241 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-3-cyclohexyl-L-alanyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, ACETATE ION | 著者 | Forouhar, F, Liu, H, Iketani, S, Zack, A, Khanizeman, N, Bednarova, E, Fowler, B, Hong, S.J, Mohri, H, Nair, M.S, Huang, Y, Tay, N.E.S, Lee, S, Karan, C, Resnick, S.J, Quinn, C, Li, W, Shion, H, Jurtschenko, C, Lauber, M.A, McDonald, T, Stokes, M, Hurst, B, Rovis, T, Chavez, A, Ho, D.D, Stockwell, B.R. | 登録日 | 2022-01-14 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun, 13, 2022
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1UCA
| Crystal structure of the Ribonuclease MC1 from bitter gourd seeds complexed with 2'-UMP | 分子名称: | PHOSPHORIC ACID MONO-[2-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-YL] ESTER, Ribonuclease MC | 著者 | Suzuki, A, Yao, M, Tanaka, I, Numata, T, Kikukawa, S, Yamasaki, N, Kimura, M. | 登録日 | 2003-04-10 | 公開日 | 2003-04-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Crystal structures of the ribonuclease MC1 from bitter gourd seeds, complexed with 2'-UMP or 3'-UMP, reveal structural basis for uridine specificity Biochem.Biophys.Res.Commun., 275, 2000
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8J4C
| YeeE(TsuA)-YeeD(TsuB) complex for thiosulfate uptake | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Spirochaeta thermophila YeeE(TsuA)-YeeD(TsuB),UPF0033 domain-containing protein, SirA-like domain-containing protein (chimera), ... | 著者 | Ikei, M, Miyazaki, R, Monden, K, Naito, Y, Takeuchi, A, Takahashi, Y.S, Tanaka, Y, Ichikawa, M, Tsukazaki, T. | 登録日 | 2023-04-19 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Structure and function of YeeE-YeeD complex for sophisticated thiosulfate uptake To Be Published
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1UC5
| Structure of diol dehydratase complexed with (R)-1,2-propanediol | 分子名称: | AMMONIUM ION, CYANOCOBALAMIN, POTASSIUM ION, ... | 著者 | Shibata, N, Nakanishi, Y, Fukuoka, M, Yamanishi, M, Yasuoka, N, Toraya, T. | 登録日 | 2003-04-08 | 公開日 | 2003-07-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase J.Biol.Chem., 278, 2003
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4MOY
| Structure of a second nuclear PP1 Holoenzyme, crystal form 1 | 分子名称: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Choy, M.S, Hieke, M, Peti, W, Page, R. | 登録日 | 2013-09-12 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1953 Å) | 主引用文献 | Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. Proc.Natl.Acad.Sci.USA, 111, 2014
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4N7W
| Crystal Structure of the sodium bile acid symporter from Yersinia frederiksenii | 分子名称: | CITRIC ACID, Transporter, sodium/bile acid symporter family, ... | 著者 | Zhou, X, Levin, E.J, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2013-10-16 | 公開日 | 2013-12-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | 主引用文献 | Structural basis of the alternating-access mechanism in a bile acid transporter. Nature, 505, 2013
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1U3C
| Crystal Structure of the PHR domain of Cryptochrome 1 from Arabidopsis thaliana | 分子名称: | CHLORIDE ION, Cryptochrome 1 apoprotein, ETHYL DIMETHYL AMMONIO PROPANE SULFONATE, ... | 著者 | Brautigam, C.A, Smith, B.S, Ma, Z, Palnitkar, M, Tomchick, D.R, Machius, M, Deisenhofer, J. | 登録日 | 2004-07-21 | 公開日 | 2004-08-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana. Proc.Natl.Acad.Sci.USA, 101, 2004
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1TS6
| Structure of the pB2 intermediate from time-resolved Laue crystallography | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | 著者 | Ihee, H, Rajagopal, S, Srajer, V, Pahl, R, Anderson, S, Schmidt, M, Schotte, F, Anfinrud, P.A, Wulff, M, Moffat, K. | 登録日 | 2004-06-21 | 公開日 | 2005-07-05 | 最終更新日 | 2021-07-07 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1UC9
| Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, lysine biosynthesis enzyme | 著者 | Sakai, H, Vassylyeva, M.N, Matsuura, T, Sekine, S, Nishiyama, M, Terada, T, Shirouzu, M, Kuramitsu, S, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-04-09 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Crystal Structure of a Lysine Biosynthesis Enzyme, LysX, from Thermus thermophilus HB8 J.Mol.Biol., 332, 2003
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1TS8
| Structure of the pR cis planar intermediate from time-resolved Laue crystallography | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | 著者 | Ihee, H, Rajagopal, S, Srajer, V, Pahl, R, Anderson, S, Schmidt, M, Schotte, F, Anfinrud, P.A, Wulff, M, Moffat, K. | 登録日 | 2004-06-21 | 公開日 | 2005-07-05 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Visualizing reaction pathways in photoactive yellow protein from nanoseconds to seconds. Proc.Natl.Acad.Sci.Usa, 102, 2005
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8J0N
| cryo-EM structure of human EMC | 分子名称: | ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | 著者 | Li, M, Zhang, C, Wu, J, Lei, M. | 登録日 | 2023-04-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural insights into human EMC and its interaction with VDAC. Aging (Albany NY), 16, 2024
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8J0O
| cryo-EM structure of human EMC and VDAC | 分子名称: | ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | 著者 | Li, M, Zhang, C, Wu, J, Lei, M. | 登録日 | 2023-04-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural insights into human EMC and its interaction with VDAC. Aging (Albany NY), 16, 2024
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1UC8
| Crystal structure of a lysine biosynthesis enzyme, Lysx, from thermus thermophilus HB8 | 分子名称: | lysine biosynthesis enzyme | 著者 | Sakai, H, Vassylyeva, M.N, Matsuura, T, Sekine, S, Nishiyama, M, Terada, T, Shirouzu, M, Kuramitsu, S, Vassylyev, D.G, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-04-09 | 公開日 | 2003-09-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of a Lysine Biosynthesis Enzyme, LysX, from Thermus thermophilus HB8 J.Mol.Biol., 332, 2003
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1U1Z
| The Structure of (3R)-hydroxyacyl-ACP dehydratase (FabZ) | 分子名称: | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase, SULFATE ION | 著者 | Kimber, M.S, Martin, F, Lu, Y, Houston, S, Vedadi, M, Dharamsi, A, Fiebig, K.M, Schmid, M, Rock, C.O. | 登録日 | 2004-07-16 | 公開日 | 2004-09-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa J.Biol.Chem., 279, 2004
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