7LXY
 
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7LY3
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7LO8
 | | NorA in complex with Fab36 | | 分子名称: | Fab36 Heavy Chain, Fab36 Light Chain, Quinolone resistance protein NorA | | 著者 | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | | 登録日 | 2021-02-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
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7LO7
 | | NorA in complex with Fab25 | | 分子名称: | Fab25 Heavy Chain, Fab25 Light Chain, Quinolone resistance protein NorA | | 著者 | Brawley, D.N, Sauer, D.B, Song, J.M, Koide, A, Koide, S, Traaseth, N.J, Wang, D.N. | | 登録日 | 2021-02-09 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus.
Nat.Chem.Biol., 18, 2022
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7MHC
 | | Structure of human STING in complex with MK-1454 | | 分子名称: | (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | | 著者 | Lesburg, C.A. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature, 603, 2022
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7E0B
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7MSA
 | | GDC-9545 in complex with estrogen receptor alpha | | 分子名称: | (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, 3-[(1R,3R)-1-(2,6-difluoro-4-{[1-(3-fluoropropyl)azetidin-3-yl]amino}phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl]-2,2-difluoropropan-1-ol, Estrogen receptor | | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Zbieg, J.R, Wang, X, Ortwine, D.F. | | 登録日 | 2021-05-10 | | 公開日 | 2021-06-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J.Med.Chem., 64, 2021
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7ML7
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5YIM
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5YIJ
 | | Structure of a Legionella effector with substrates | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SdeA, Ubiquitin | | 著者 | Feng, Y, Mu, Y, Wang, H. | | 登録日 | 2017-10-05 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Structural basis of ubiquitin modification by the Legionella effector SdeA.
Nature, 557, 2018
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7D3M
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7D3K
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7D3R
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7D3L
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6J1Z
 | | WWP2 semi-open conformation | | 分子名称: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | | 著者 | Liu, Z.H. | | 登録日 | 2018-12-30 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
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8T5Q
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8T5P
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6J1X
 | | WWP1 close conformation | | 分子名称: | GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1 | | 著者 | Liu, Z.H. | | 登録日 | 2018-12-30 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
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6J1Y
 | | Semi-open conformation E3 ligase | | 分子名称: | GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1 | | 著者 | Liu, Z.H. | | 登録日 | 2018-12-30 | | 公開日 | 2019-07-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
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7EY6
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7EY8
 | | portal | | 分子名称: | Portal protein | | 著者 | Liu, H.R, Chen, W.Y. | | 登録日 | 2021-05-30 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural changes in bacteriophage T7 upon receptor-induced genome ejection.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7EYB
 | | core proteins | | 分子名称: | Internal virion protein gp14, Internal virion protein gp15, Peptidoglycan transglycosylase gp16 | | 著者 | Liu, H.R, Chen, W.Y. | | 登録日 | 2021-05-30 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural changes in bacteriophage T7 upon receptor-induced genome ejection.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7EY9
 | | tail proteins | | 分子名称: | Tail fiber protein, Tail tubular protein gp11, Tail tubular protein gp12 | | 著者 | Liu, H.R, Chen, W.Y. | | 登録日 | 2021-05-30 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural changes in bacteriophage T7 upon receptor-induced genome ejection.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7EY7
 | | bacteriophage T7 tail complex | | 分子名称: | Internal virion protein gp14, Tail fiber protein, Tail tubular protein gp11, ... | | 著者 | Liu, H.R, Chen, W.Y. | | 登録日 | 2021-05-30 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural changes in bacteriophage T7 upon receptor-induced genome ejection.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7FEI
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