2VWU
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![BU of 2vwu by Molmil](/molmil-images/mine/2vwu) | ephB4 kinase domain inhibitor complex | 分子名称: | EPHRIN TYPE-B RECEPTOR 4, N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | 著者 | Read, J, Brassington, C.A, Green, I, McCall, E.J, Valentine, A.L, Barratt, D, Rowsell, S, Packer, M, McAlister, M. | 登録日 | 2008-06-27 | 公開日 | 2008-07-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines Bioorg.Med.Chem.Lett., 18, 2008
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5OPL
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![BU of 5opl by Molmil](/molmil-images/mine/5opl) | Crystal structure of K25E cN-II mutant | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION | 著者 | Kugler, M, Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPM
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![BU of 5opm by Molmil](/molmil-images/mine/5opm) | Crystal structure of D52N/R238W cN-II mutant bound to dATP and free phosphate | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPP
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![BU of 5opp by Molmil](/molmil-images/mine/5opp) | Crystal structure of S408R cN-II mutant | 分子名称: | BROMIDE ION, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPN
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![BU of 5opn by Molmil](/molmil-images/mine/5opn) | Crystal structure of R39Q cN-II mutant | 分子名称: | Cytosolic purine 5'-nucleotidase, GLYCEROL | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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5OPK
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![BU of 5opk by Molmil](/molmil-images/mine/5opk) | Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, GLYCEROL, ... | 著者 | Hnizda, A, Pachl, P, Rezacova, P. | 登録日 | 2017-08-10 | 公開日 | 2018-06-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32, 2018
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4GRB
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![BU of 4grb by Molmil](/molmil-images/mine/4grb) | Casein kinase 2 (CK2) bound to inhibitor | 分子名称: | 5-(2-{[4-(dimethylcarbamoyl)phenyl]amino}-4-methoxypyrimidin-5-yl)thiophene-3-carboxylic acid, CHLORIDE ION, Casein kinase II subunit alpha | 著者 | Larsen, N.A, Dowling, J.E, Ferguson, A.D. | 登録日 | 2012-08-24 | 公開日 | 2013-08-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett, 4, 2013
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4JF2
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![BU of 4jf2 by Molmil](/molmil-images/mine/4jf2) | |
7T3E
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![BU of 7t3e by Molmil](/molmil-images/mine/7t3e) | Structure of the sialic acid bound Tripartite ATP-independent Periplasmic (TRAP) periplasmic component SiaP from Photobacterium profundum | 分子名称: | N-acetyl-beta-neuraminic acid, SULFATE ION, TRAP-type C4-dicarboxylate transport system, ... | 著者 | Davies, J.S, Currie, M.J, North, R.A, Dobson, R.C.J. | 登録日 | 2021-12-07 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter. Nat Commun, 14, 2023
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7SXN
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![BU of 7sxn by Molmil](/molmil-images/mine/7sxn) | Orb2A residues 1-9 MYNKFVNFI | 分子名称: | Orb2A residues 1-9 MYNKFVNFI | 著者 | Bowler, J.T, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | 登録日 | 2021-11-23 | 公開日 | 2022-10-05 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | 主引用文献 | Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets. J.Biol.Chem., 298, 2022
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4IWV
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![BU of 4iwv by Molmil](/molmil-images/mine/4iwv) | Crystals structure of Human Glucokinase in complex with small molecule activator | 分子名称: | (2S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-chloropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide, Glucokinase isoform 3, SODIUM ION, ... | 著者 | Ogg, D.J, Hargreaves, D, Gerhardt, S, Flavell, L, McAlister, M. | 登録日 | 2013-01-24 | 公開日 | 2013-04-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485 To be Published
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