4GRB

Casein kinase 2 (CK2) bound to inhibitor

Summary for 4GRB

• Entry DOI: 10.2210/pdb4grb/pdb
• Related: 3U4U
• Descriptor: Casein kinase II subunit alpha, CHLORIDE ION, 5-(2-{[4-(dimethylcarbamoyl)phenyl]amino}-4-methoxypyrimidin-5-yl)thiophene-3-carboxylic acid, ... (4 entities in total)
• Functional Keywords: kinase, protein kinase, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40312.39

Authors

Larsen, N.A.,Dowling, J.E.,Ferguson, A.D. (deposition date: 2012-08-24, release date: 2013-08-28, Last modification date: 2024-02-28)

• Primary citation: Dowling, J.E.,Alimzhanov, M.,Bao, L.,Block, M.H.,Chuaqui, C.,Cooke, E.L.,Denz, C.R.,Hird, A.,Huang, S.,Larsen, N.A.,Peng, B.,Pontz, T.W.,Rivard-Costa, C.,Saeh, J.C.,Thakur, K.,Ye, Q.,Zhang, T.,Lyne, P.D.; Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.; ACS Med Chem Lett, 4:800-805, 2013; PubMed: 24900749; DOI: 10.1021/ml400197u

Experimental method

X-RAY DIFFRACTION (2.15 Å)