6OPI
| phosphorylated ERK2 with SCH-CPD336 | 分子名称: | (3R)-N-[3-(2-cyclopropylpyridin-4-yl)-1H-indazol-5-yl]-3-(methoxymethyl)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}ethyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1 | 著者 | Vigers, G.P, Smith, D. | 登録日 | 2019-04-25 | 公開日 | 2019-07-31 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
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1PGE
| PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH P-(2'-IODO-5'-THENOYL)HYDROTROPIC ACID (IODOSUPROFEN) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P-(2'-IODO-5'-THENOYL)HYDROTROPIC ACID, ... | 著者 | Loll, P.J, Picot, D, Garavito, R.M. | 登録日 | 1995-12-02 | 公開日 | 1997-01-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site. Biochemistry, 35, 1996
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2BF0
| crystal structure of the rpr of pcf11 | 分子名称: | CALCIUM ION, PCF11 | 著者 | Noble, C.G, Hollingworth, D, Martin, S.R, Adeniran, V.E, Smerdon, S.J, Kelly, G, Taylor, I.A, Ramos, A. | 登録日 | 2004-12-02 | 公開日 | 2005-01-18 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Key Features of the Interaction between Pcf11 Cid and RNA Polymerase II Ctd. Nat.Struct.Mol.Biol., 12, 2005
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2BTQ
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6RMQ
| Crystal structure of a selenomethionine-substituted A70M I84M mutant of the essential repressor DdrO from radiation resistant-Deinococcus bacteria (Deinococcus deserti) | 分子名称: | HTH-type transcriptional regulator DdrOC | 著者 | Arnoux, P, Siponen, M.I, Pignol, D, De Groot, A, Blanchard, L. | 登録日 | 2019-05-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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6OFA
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6HPX
| Crystal structure of ENL (MLLT1) in complex with compound 19 | 分子名称: | 1,2-ETHANEDIOL, Protein ENL, ~{N}-[(3-chlorophenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole-5-carboxamide | 著者 | Heidenreich, D, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2018-09-22 | 公開日 | 2018-11-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J.Med.Chem., 61, 2018
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2C1N
| Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | 分子名称: | 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE | 著者 | Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. | 登録日 | 2005-09-16 | 公開日 | 2005-11-02 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
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2BN8
| Solution Structure and interactions of the E .coli Cell Division Activator Protein CedA | 分子名称: | CELL DIVISION ACTIVATOR CEDA | 著者 | Chen, H.A, Simpson, P, Huyton, T, Roper, D, Matthews, S. | 登録日 | 2005-03-22 | 公開日 | 2006-12-21 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure and Interactions of the Escherichia Coli Cell Division Activator Protein Ceda. Biochemistry, 44, 2005
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2BKR
| NEDD8 NEDP1 complex | 分子名称: | NEDDYLIN, SENTRIN-SPECIFIC PROTEASE 8 | 著者 | Shen, L.N, Liu, H, Dong, C, Xirodimas, D, Naismith, J.H, Hay, R.T. | 登録日 | 2005-02-18 | 公開日 | 2005-09-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis of Nedd8 Ubiquitin Discrimination by the Deneddylating Enzyme Nedp1 Embo J., 24, 2005
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6P4B
| HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S) | 分子名称: | CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain, ... | 著者 | Langley, D.B, Christ, D. | 登録日 | 2019-05-27 | 公開日 | 2020-05-27 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
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2C61
| Crystal structure of the non-catalytic B subunit of A-type ATPase from M. mazei Go1 | 分子名称: | A-TYPE ATP SYNTHASE NON-CATALYTIC SUBUNIT B | 著者 | Schaefer, I, Bailer, S.M, Dueser, M, Boersch, M, Bernal, R.A, Grueber, G, Stock, D. | 登録日 | 2005-11-06 | 公開日 | 2006-12-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of the Archaeal A1Ao ATP Synthase Subunit B from Methanosarcina Mazei Go1: Implications of Nucleotide-Binding Differences in the Major A1Ao Subunits a and B. Subunits a and B J.Mol.Biol., 358, 2006
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2BJC
| NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor headpiece that mimics the gal repressor | 分子名称: | 5'-D(*GP*AP*AP*TP*TP*GP*TP*AP*AP*GP *CP*GP*CP*TP*TP*AP*CP*AP*AP*TP*TP*C)-3', LACTOSE OPERON REPRESSOR | 著者 | Salinas, R.K, Folkers, G.E, Bonvin, A.M.J.J, Das, D, Boelens, R, Kaptein, R. | 登録日 | 2005-02-01 | 公開日 | 2005-10-18 | 最終更新日 | 2020-01-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Altered Specificity in DNA Binding by the Lac Repressor: A Mutant Lac Headpiece that Mimics the Gal Repressor Chembiochem, 6, 2005
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2BN6
| P-Element Somatic Inhibitor Protein | 分子名称: | PSI | 著者 | Ignjatovic, T, Yang, J.C, Butler, P.J.G, Neuhaus, D, Nagai, K. | 登録日 | 2005-03-21 | 公開日 | 2005-07-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of the Interaction between P-Element Somatic Inhibitor and U1-70K Essential for the Alternative Splicing of P-Element Transposase. J.Mol.Biol., 351, 2005
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6P4C
| HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F | 分子名称: | CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain | 著者 | Langley, D.B, Christ, D. | 登録日 | 2019-05-27 | 公開日 | 2020-05-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020
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1PGF
| PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL | 分子名称: | 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Loll, P.J, Picot, D, Garavito, R.M. | 登録日 | 1995-12-02 | 公開日 | 1997-01-11 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | 主引用文献 | Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site. Biochemistry, 35, 1996
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2E2J
| RNA polymerase II elongation complex in 5 mM Mg+2 with GMPCPP | 分子名称: | 27-MER DNA template strand, 5'-D(P*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*A)-3', 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3', ... | 著者 | Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. | 登録日 | 2006-11-14 | 公開日 | 2006-12-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
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2EB4
| Crystal structure of apo-HpcG | 分子名称: | 2-oxo-hept-3-ene-1,7-dioate hydratase, SODIUM ION, THIOCYANATE ION | 著者 | Izumi, A, Rea, D, Adachi, T, Unzai, S, Park, S.Y, Roper, D.I, Tame, J.R.H. | 登録日 | 2007-02-07 | 公開日 | 2007-07-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli J.Mol.Biol., 370, 2007
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6GOY
| Structure of mEos4b in the green fluorescent state | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | De Zitter, E, Adam, V, Byrdin, M, Van Meervelt, L, Dedecker, P, Bourgeois, D. | 登録日 | 2018-06-04 | 公開日 | 2019-05-22 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Mechanistic investigation of mEos4b reveals a strategy to reduce track interruptions in sptPALM. Nat.Methods, 16, 2019
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6E4L
| The structure of the N-terminal domain of human clathrin heavy chain 1 (nTD) in complex with ES9 | 分子名称: | 1,2-ETHANEDIOL, 5-bromo-N-(4-nitrophenyl)thiophene-2-sulfonamide, ACETATE ION, ... | 著者 | Dejonghe, W, Sharma, I, Denoo, B, Munck, S.D, Bulut, H, Mylle, E, Vasileva, M, Lu, Q, Savatin, D.V, Mishev, K, Nerinckx, W, Staes, A, Drozdzecki, A, Audenaert, D, Madder, A, Friml, J, Damme, D.V, Gevaert, K, Haucke, V, Savvides, S, Winne, J, Russinova, E. | 登録日 | 2018-07-17 | 公開日 | 2019-04-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nat.Chem.Biol., 15, 2019
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6OQ2
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6R7P
| Crystal structure of oxidized Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE and NuoF S96M | 分子名称: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Wohlwend, D, Gnandt, E, Friedrich, T. | 登録日 | 2019-03-29 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I. Nat Commun, 10, 2019
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3MG3
| Crystal structure of the orange carotenoid protein R155L mutant from cyanobacteria synechocystis sp. PCC 6803 | 分子名称: | GLYCEROL, Orange carotenoid-binding protein, beta,beta-caroten-4-one | 著者 | Wilson, A, Kinney, J, Zwart, P.H, Punginelli, C, D'Haen, S, Perreau, F, Klein, M.G, Kirilovsky, D, Kerfeld, C.A. | 登録日 | 2010-04-05 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | Structural determinants underlying photoprotection in the photoactive orange carotenoid protein of cyanobacteria. J.Biol.Chem., 285, 2010
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6OTX
| Crystallographic Structure of (HbII-HbIII)-O2 from Lucina pectinata at pH 7.0 | 分子名称: | Hemoglobin II, Hemoglobin III, OXYGEN MOLECULE, ... | 著者 | Marchany-Rivera, D, Smith, C.A, Rodriguez-Perez, J.D, Lopez-Garriga, J. | 登録日 | 2019-05-03 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.539 Å) | 主引用文献 | Lucina pectinata oxyhemoglobin (II-III) heterodimer pH susceptibility. J.Inorg.Biochem., 207, 2020
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3MHL
| Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide | 分子名称: | 4-{[(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Grazulis, S, Manakova, E, Golovenko, D. | 登録日 | 2010-04-08 | 公開日 | 2010-10-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | 4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII Bioorg.Med.Chem., 18, 2010
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