4O6E
| Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2 | 分子名称: | Mitogen-activated protein kinase 1, N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2H-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxamide | 著者 | Yin, J, Wang, W. | 登録日 | 2013-12-20 | 公開日 | 2014-05-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorg.Med.Chem.Lett., 24, 2014
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4O0Y
| Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors | 分子名称: | 4-[1-(4-amino-1,3,5-triazin-2-yl)-2-(ethylamino)-1H-benzimidazol-6-yl]-2-methylbut-3-yn-2-ol, Serine/threonine-protein kinase PAK 4 | 著者 | Rouge, L, Tam, C, Wang, W. | 登録日 | 2013-12-14 | 公開日 | 2014-02-12 | 最終更新日 | 2014-02-26 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors. J.Med.Chem., 57, 2014
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4O0T
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4G9Z
| Lassa nucleoprotein with dsRNA reveals novel mechanism for immune suppression | 分子名称: | Nucleoprotein, RNA (5'-R(P*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*C)-3'), ... | 著者 | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C, Scottish Structural Proteomics Facility (SSPF) | 登録日 | 2012-07-24 | 公開日 | 2013-04-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4MIW
| High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase | 分子名称: | MAGNESIUM ION, RNA-directed RNA polymerase L | 著者 | Wallat, G.D, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | 登録日 | 2013-09-02 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase in complex with magnesium ions. Plos One, 9, 2014
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4GV6
| Structures of Lassa and Tacaribe viral nucleoproteins with or without 5 triphosphate dsRNA substrate reveal a unique 3 -5 exoribonuclease mechanism to suppress type I interferon production | 分子名称: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | 著者 | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | 登録日 | 2012-08-30 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4GVE
| Tacaribe nucleoprotein structure | 分子名称: | MAGNESIUM ION, Nucleoprotein, ZINC ION | 著者 | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | 登録日 | 2012-08-30 | 公開日 | 2013-05-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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4GV9
| Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min | 分子名称: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | 著者 | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | 登録日 | 2012-08-30 | 公開日 | 2013-05-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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7CSZ
| Crystal structure of the N-terminal tandem RRM domains of RBM45 in complex with single-stranded DNA | 分子名称: | DNA (5'-D(*CP*GP*AP*CP*GP*GP*GP*AP*CP*GP*C)-3'), RNA-binding protein 45 | 著者 | Chen, X, Yang, Z, Wang, W, Wang, M. | 登録日 | 2020-08-17 | 公開日 | 2021-02-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45. Nucleic Acids Res., 49, 2021
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7CSX
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1AFF
| DNA QUADRUPLEX CONTAINING GGGG TETRADS AND (T.A).A TRIADS, NMR, 8 STRUCTURES | 分子名称: | QUADRUPLEX DNA (5'-D(TP*AP*GP*G)-3') | 著者 | Kettani, A, Bouaziz, S, Wang, W, Jones, R.A, Patel, D.J. | 登録日 | 1997-03-06 | 公開日 | 1997-08-20 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Bombyx mori single repeat telomeric DNA sequence forms a G-quadruplex capped by base triads. Nat.Struct.Biol., 4, 1997
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1B3P
| 5'-D(*GP*GP*AP*GP*GP*AP*T)-3' | 分子名称: | DNA (5'-D(*GP*GP*AP*GP*GP*AP*T)-3') | 著者 | Kettani, A, Bouaziz, S, Skripkin, E, Majumdar, A, Wang, W, Jones, R.A, Patel, D.J. | 登録日 | 1998-12-14 | 公開日 | 1999-08-31 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Interlocked mismatch-aligned arrowhead DNA motifs. Structure Fold.Des., 7, 1999
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6JLU
| Structure of PSII-FCP supercomplex from a centric diatom Chaetoceros gracilis at 3.02 angstrom resolution | 分子名称: | (3S,3'R,5R,6S,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol, (3S,3'S,5R,5'R,6S,6'R,8'R)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'-yl acetate, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | 著者 | Pi, X, Zhao, S, Wang, W, Kuang, T, Sui, S, Shen, J. | 登録日 | 2019-03-06 | 公開日 | 2019-07-31 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex. Science, 365, 2019
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7CLU
| PigF with SAH | 分子名称: | ACETATE ION, GLYCEROL, Methyltransferase domain-containing protein | 著者 | Qiu, S, Xu, D, Han, N, Sun, B, Ran, T, Wang, W. | 登録日 | 2020-07-22 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism. Iucrj, 9, 2022
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7DKZ
| Structure of plant photosystem I-light harvesting complex I supercomplex | 分子名称: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Wang, J, Yu, L.J, Wang, W. | 登録日 | 2020-11-25 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | Structure of plant photosystem I-light harvesting complex I supercomplex at 2.4 angstrom resolution. J Integr Plant Biol, 63, 2021
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7L31
| Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state, 3.8 Angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-2, Glycine receptor subunit beta,Green fluorescent protein, ... | 著者 | Yu, H, Wang, W. | 登録日 | 2020-12-17 | 公開日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Characterization of the subunit composition and structure of adult human glycine receptors Neuron, 109, 2021
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7KUY
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7F77
| Crystal structure of glutamate dehydrogenase 3 from Candida albicans | 分子名称: | Glutamate dehydrogenase | 著者 | Li, N, Wang, W, Zeng, X, Liu, M, Li, M, Li, C, Wang, M. | 登録日 | 2021-06-28 | 公開日 | 2021-07-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.086 Å) | 主引用文献 | Crystal structure of glutamate dehydrogenase 3 from Candida albicans. Biochem.Biophys.Res.Commun., 570, 2021
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7F79
| Crystal structure of glutamate dehydrogenase 3 from Candida albicans in complex with alpha-ketoglutarate and NADPH | 分子名称: | 2-OXOGLUTARIC ACID, GLYCEROL, Glutamate dehydrogenase, ... | 著者 | Li, N, Wang, W, Zeng, X, Liu, M, Li, M, Li, C, Wang, M. | 登録日 | 2021-06-28 | 公開日 | 2021-07-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of glutamate dehydrogenase 3 from Candida albicans. Biochem.Biophys.Res.Commun., 570, 2021
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7E1V
| Cryo-EM structure of apo hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV | 分子名称: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, CARDIOLIPIN, ... | 著者 | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | 登録日 | 2021-02-03 | 公開日 | 2021-10-13 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E1X
| Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in presence of TB47 | 分子名称: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide, ... | 著者 | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | 登録日 | 2021-02-03 | 公開日 | 2021-10-27 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E1W
| Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in the presence of Q203 | 分子名称: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide, ... | 著者 | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | 登録日 | 2021-02-03 | 公開日 | 2021-10-27 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7C91
| Blasnase-T13A with D-asn | 分子名称: | D-ASPARAGINE, FORMIC ACID, L-asparaginase, ... | 著者 | Lu, F, Ran, T, Jiao, L, Wang, W. | 登録日 | 2020-06-04 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structures of l-asparaginase from Bacillus licheniformis Reveal an Essential Residue for its Substrate Stereoselectivity. J.Agric.Food Chem., 69, 2021
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7CBU
| Blasnase-T13A with L-Asp | 分子名称: | ASPARTIC ACID, FORMIC ACID, L-asparaginase, ... | 著者 | Lu, F, Ran, T, Jiao, L, Wang, W. | 登録日 | 2020-06-14 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structures of l-asparaginase from Bacillus licheniformis Reveal an Essential Residue for its Substrate Stereoselectivity. J.Agric.Food Chem., 69, 2021
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7CB4
| Crystal structures of of BlAsnase | 分子名称: | FORMIC ACID, GLYCEROL, L-asparaginase, ... | 著者 | Lu, F, Ran, T, Jiao, L, Wang, W. | 登録日 | 2020-06-10 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structures of l-asparaginase from Bacillus licheniformis Reveal an Essential Residue for its Substrate Stereoselectivity. J.Agric.Food Chem., 69, 2021
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