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6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
分子名称: Bromodomain-containing protein 4, FOXO3a peptide
著者Zeng, L, Zhou, M.-M.
登録日2018-10-02
公開日2018-10-31
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
6BNH
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BU of 6bnh by Molmil
Solution NMR structures of BRD4 ET domain with JMJD6 peptide
分子名称: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Bromodomain-containing protein 4
著者Konuma, T, Yu, D, Zhao, C, Ju, Y, Sharma, R, Ren, C, Zhang, Q, Zhou, M.-M, Zeng, L.
登録日2017-11-16
公開日2017-12-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.
Sci Rep, 7, 2017
2RO1
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BU of 2ro1 by Molmil
NMR Solution Structures of Human KAP1 PHD finger-bromodomain
分子名称: Transcription intermediary factor 1-beta, ZINC ION
著者Zeng, L, Yap, K.L, Ivanov, A.V, Wang, X, Mujtaba, S, Plotnikova, O, Rauscher, F.J.
登録日2008-03-04
公開日2008-05-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
Nat.Struct.Mol.Biol., 15, 2008
2MJV
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BU of 2mjv by Molmil
Solution structures of second bromodomain of Brd4 with di-acetylated Twist peptide
分子名称: Bromodomain-containing protein 4, Twist-related protein 1
著者Zeng, L, Zhou, M.
登録日2014-01-16
公開日2014-03-19
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer.
Cancer Cell, 25, 2014
1BVH
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BU of 1bvh by Molmil
SOLUTION STRUCTURE OF A LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE
分子名称: ACID PHOSPHATASE
著者Logan, T.M, Zhou, M.-M, Nettesheim, D.G, Meadows, R.P, Van Etten, R.L, Fesik, S.W.
登録日1994-05-03
公開日1994-07-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of a low molecular weight protein tyrosine phosphatase.
Biochemistry, 33, 1994
3DWH
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BU of 3dwh by Molmil
Structural and Functional Analysis of SRA domain
分子名称: E3 ubiquitin-protein ligase UHRF1, GLYCEROL, SULFATE ION
著者Qian, C, Jakoncic, J, Zhou, M.
登録日2008-07-22
公開日2008-10-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1.
J.Biol.Chem., 283, 2008
2L5D
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BU of 2l5d by Molmil
Solution Structures of human PIWI-like 1 PAZ domain with ssRNA (5'-pUGACA)
分子名称: 5'-R(*UP*GP*AP*CP*A)-3', Piwi-like protein 1
著者Zeng, L, Zhang, Q, Yan, K, Zhou, M.
登録日2010-10-29
公開日2011-04-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
1HZM
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BU of 1hzm by Molmil
STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
分子名称: DUAL SPECIFICITY PROTEIN PHOSPHATASE 6
著者Farooq, A, Zhou, M.-M.
登録日2001-01-25
公開日2002-01-25
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Mol.Cell, 7, 2001
2LSP
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BU of 2lsp by Molmil
solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide
分子名称: Bromodomain-containing protein 4, NF-kB-K310ac peptide
著者Zhang, G, Liu, R, Zhong, Y, Plotnikov, A.N, Zhang, W, Rusinova, E, Gerona-Nevarro, G, Moshkina, N, Joshua, J, Chuang, P.Y, Ohlmeyer, M, He, J, Zhou, M.-M.
登録日2012-05-03
公開日2012-07-18
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.
J.Biol.Chem., 287, 2012
2L85
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BU of 2l85 by Molmil
Solution NMR structures of CBP bromodomain with small molecule of HBS
分子名称: 4-[(E)-(4-hydroxyphenyl)diazenyl]benzenesulfonic acid, CREB-binding protein
著者Borah, J.C, Mujtaba, S, Karakikes, I, Zeng, L, Muller, M, Patel, J, Moshkina, N, Morohashi, K, Zhang, W, Gerona-Navarro, G, Hajjar, R.J, Zhou, M.
登録日2011-01-04
公開日2011-01-19
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Chem.Biol., 18, 2011
2MFQ
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BU of 2mfq by Molmil
NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB
分子名称: BDNF/NT-3 growth factors receptor, Fibroblast growth factor receptor substrate 2
著者Zeng, L, Zhou, M.
登録日2013-10-18
公開日2014-03-05
最終更新日2014-06-25
実験手法SOLUTION NMR
主引用文献Structural insights into FRS2 alpha PTB domain recognition by neurotrophin receptor TrkB.
Proteins, 82, 2014
1JSP
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BU of 1jsp by Molmil
NMR Structure of CBP Bromodomain in complex with p53 peptide
分子名称: CREB-BINDING PROTEIN, tumor protein p53
著者He, Y, Mujtaba, S, Zeng, L, Yan, S, Zhou, M.-M.
登録日2001-08-17
公開日2002-08-17
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Mol.Cell, 13, 2004
2NCZ
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BU of 2ncz by Molmil
Solution NMR structures of BRD4 ET domain in complex with NSD3_1 peptide
分子名称: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
著者Zeng, L, Zhou, M.
登録日2016-04-18
公開日2016-06-29
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2ND1
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BU of 2nd1 by Molmil
Solution NMR structures of BRD4 ET domain in complex with NSD3_3 peptide
分子名称: Bromodomain-containing protein 4, Histone-lysine N-methyltransferase NSD3
著者Zeng, L, Zhou, M.
登録日2016-04-19
公開日2016-06-29
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2NDF
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BU of 2ndf by Molmil
Solution NMR structures of AF9 yeats domain in complex with histon H3 acetylation at K18
分子名称: Histone H3 peptide, Protein AF-9
著者Zeng, L, Zhou, M.
登録日2016-05-19
公開日2016-09-07
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2NDG
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BU of 2ndg by Molmil
Solution NMR structures of AF9 yeats domain in complex with histone H3 crotonylation at K18
分子名称: Histone H3 peptide, Protein AF-9
著者Zeng, L, Zhou, M.
登録日2016-05-19
公開日2016-09-07
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain.
Structure, 24, 2016
2ND0
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BU of 2nd0 by Molmil
Solution NMR structures of BRD4 ET domain with LANA peptide
分子名称: Bromodomain-containing protein 4, LANA
著者Zeng, L, Zhou, M.
登録日2016-04-18
公開日2016-06-29
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4.
Structure, 24, 2016
2L5C
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BU of 2l5c by Molmil
Solution structures of human PIWI-like 1 PAZ domain
分子名称: Piwi-like protein 1
著者Zeng, L, Zhang, Q, Yan, K, Zhou, M.
登録日2010-10-29
公開日2011-04-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.
Proteins, 79, 2011
2L84
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BU of 2l84 by Molmil
Solution NMR structures of CBP bromodomain with small molecule j28
分子名称: 5-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid, CREB-binding protein
著者Borah, J.C, Mujtaba, S, Karakikes, I, Zeng, L, Muller, M, Patel, J, Moshkina, N, Morohashi, K, Zhang, W, Gerona-Navarro, G, Hajjar, R.J, Zhou, M.
登録日2011-01-03
公開日2011-01-19
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Chem.Biol., 18, 2011
5ULA
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BU of 5ula by Molmil
Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402
分子名称: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4
著者Plotnikov, A.N, Joshua, j, Zhou, M.-M.
登録日2017-01-24
公開日2017-03-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U5S
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BU of 5u5s by Molmil
Solution structures of Brd2 second bromodomain in complex with stat3 peptide
分子名称: Bromodomain-containing protein 2, Stat3 peptide
著者Zeng, L, Zhou, M.-M.
登録日2016-12-07
公開日2017-03-22
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Mol. Cell, 65, 2017
3QB8
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BU of 3qb8 by Molmil
Paramecium Chlorella Bursaria Virus1 Putative ORF A654L is a Polyamine Acetyltransferase
分子名称: A654L protein, COENZYME A, IMIDAZOLE
著者Charlop-Powers, Z, Zhou, M.-M, Jakoncic, J, Gurnon, J, Van Etten, J.
登録日2011-01-12
公開日2012-01-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase.
J. Biol. Chem., 287, 2012
2LXE
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BU of 2lxe by Molmil
S4wyild
分子名称: Histone-lysine N-methyltransferase SUVR4
著者Kristiansen, P, Rahman, M.A, Aalen, R.B.
登録日2012-08-20
公開日2013-11-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure.
Biochemistry, 53, 2014
5Z9C
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BU of 5z9c by Molmil
Solution NMR structures of BRD4 first bromodomain with small compound MMQO
分子名称: 8-methoxy-6-methylquinolin-4(1H)-one, Bromodomain-containing protein 4
著者Zeng, L, Zhou, M.-M.
登録日2018-02-02
公開日2018-02-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
J. Virol., 92, 2018
4N4F
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BU of 4n4f by Molmil
Crystal Structure of the Bromodomain-PHD Finger Module of Human Transcriptional Co-Activator CBP in complex with di-Acetylated Histone 4 Peptide (H412acK16ac).
分子名称: CREB-binding protein, Histone 4 Peptide, ZINC ION
著者Plotnikov, A.N, Zhou, J, Zhou, M.-M.
登録日2013-10-08
公開日2014-02-19
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP.
Structure, 22, 2014

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