6V4E
 
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6V4F
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6VO4
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7UK2
 | | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with NN-390 | | 分子名称: | Hdac6 protein, N-hydroxy-4-{[(propan-2-yl)(2,3,4,5-tetrafluorobenzene-1-sulfonyl)amino]methyl}benzamide, POTASSIUM ION, ... | | 著者 | Erdogan, F, Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2022-03-31 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.
Pharmaceuticals, 15, 2022
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5VSB
 | | Structure of DUB complex | | 分子名称: | 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2017-05-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
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5VS6
 | | Structure of DUB complex | | 分子名称: | ACETATE ION, GLYCEROL, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ... | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2017-05-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2018-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
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5VSK
 | | Structure of DUB complex | | 分子名称: | 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION | | 著者 | Seo, H.-Y, Dhe-Paganon, S. | | 登録日 | 2017-05-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2018-01-03 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
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5WHH
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5WHI
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3MMY
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5JWM
 | | Bivalent BET Bromodomain Inhibition | | 分子名称: | 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4 | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2016-05-12 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Design and characterization of bivalent BET inhibitors.
Nat.Chem.Biol., 12, 2016
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3F3P
 | | Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21212 | | 分子名称: | Nucleoporin NUP85, Nucleoporin SEH1 | | 著者 | Debler, E.W, Hseo, H, Ma, Y, Blobel, G, Hoelz, A. | | 登録日 | 2008-10-31 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | A fence-like coat for the nuclear pore membrane.
Mol.Cell, 32, 2008
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3F3F
 | | Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21 | | 分子名称: | Nucleoporin NUP85, Nucleoporin SEH1 | | 著者 | Debler, E.W, Hseo, H, Ma, Y, Blobel, G, Hoelz, A. | | 登録日 | 2008-10-30 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A fence-like coat for the nuclear pore membrane.
Mol.Cell, 32, 2008
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3F3G
 | | Crystal structure of the nucleoporin pair Nup85-Seh1, space group P212121 | | 分子名称: | Nucleoporin NUP85, Nucleoporin SEH1 | | 著者 | Debler, E.W, Hseo, H, Ma, Y, Blobel, G, Hoelz, A. | | 登録日 | 2008-10-30 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | A fence-like coat for the nuclear pore membrane.
Mol.Cell, 32, 2008
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7JIF
 | | HRAS A59T GppNHp | | 分子名称: | GLYCEROL, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Haigis, K.M. | | 登録日 | 2020-07-23 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.757 Å) | | 主引用文献 | Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
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7JII
 | | HRAS A59E GDP | | 分子名称: | CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Johnson, C.W, Haigis, K.M. | | 登録日 | 2020-07-23 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.532 Å) | | 主引用文献 | Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
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7JIG
 | | HRAS A59T GppNHp crystal 2 | | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Johnson, C.W, Haigis, K.M. | | 登録日 | 2020-07-23 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.322 Å) | | 主引用文献 | Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
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7JIH
 | | HRAS A59E GppNHp | | 分子名称: | GLYCEROL, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Johnson, C.W, Haigis, K.M. | | 登録日 | 2020-07-23 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.989 Å) | | 主引用文献 | Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
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3PBP
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6MBW
 | | Structure of Transcription Factor | | 分子名称: | Signal transducer and activator of transcription 5B | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2018-08-30 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
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6MBZ
 | | Structure of Transcription Factor | | 分子名称: | Signal transducer and activator of transcription 5B | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2018-08-30 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
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7D6L
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6IZ2
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