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7QR0
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BU of 7qr0 by Molmil
SpCas9 bound to TRAC off-target1 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QR8
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BU of 7qr8 by Molmil
SpCas9 bound to PTPRC off-target1 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QQZ
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BU of 7qqz by Molmil
SpCas9 bound to FANCF off-target7 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target7 non-target strand, FANCF off-target7 target strand, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QQW
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BU of 7qqw by Molmil
SpCas9 bound to FANCF off-target4 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target4 non-target strand, FANCF off-target4 target strand, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QR1
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BU of 7qr1 by Molmil
SpCas9 bound to TRAC off-target2 DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
7QR7
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BU of 7qr7 by Molmil
SpCas9 bound to AAVS1 off-target2 DNA substrate
分子名称: AAVS1 off-target2 non-target strand, AAVS1 off-target2 target strand, AAVS1 sgRNA, ...
著者Pacesa, M, JInek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
1MWE
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BU of 1mwe by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, N-acetyl-alpha-neuraminic acid, ...
著者Varghese, J.N.
登録日1997-08-27
公開日1998-03-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.
Proc.Natl.Acad.Sci.USA, 94, 1997
6DMP
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BU of 6dmp by Molmil
De Novo Design of a Protein Heterodimer with Specificity Mediated by Hydrogen Bond Networks
分子名称: Designed orthogonal protein DHD13_XAAA_A, Designed orthogonal protein DHD13_XAAA_B
著者Chen, Z, Flores-Solis, D, Sgourakis, N.G, Baker, D.
登録日2018-06-05
公開日2018-12-19
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
6MSQ
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BU of 6msq by Molmil
Crystal structure of pRO-2.3
分子名称: pRO-2.3
著者Boyken, S.E, Sankaran, B, Bick, M.J, Baker, D.
登録日2018-10-17
公開日2019-05-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献De novo design of tunable, pH-driven conformational changes.
Science, 364, 2019
6MSR
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BU of 6msr by Molmil
Crystal structure of pRO-2.5
分子名称: pRO-2.5
著者Bick, M.J, Sankaran, B, Boyken, S.E, Baker, D.
登録日2018-10-17
公開日2019-05-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献De novo design of tunable, pH-driven conformational changes.
Science, 364, 2019
2QWF
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BU of 2qwf by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-guanidino-6-methyl(propyl) carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWK
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BU of 2qwk by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWH
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BU of 2qwh by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWA
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BU of 2qwa by Molmil
THE X-RAY STRUCTURE OF A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWJ
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BU of 2qwj by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-amino-6-diethyl carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWG
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BU of 2qwg by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-amino-6-diethyl carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWI
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BU of 2qwi by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-N-acetyl-4-guanidino-6-methyl(propyl) carboxamide-4,5-dihydro-2H-pyran-2-carboxylic acid, CALCIUM ION, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWE
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BU of 2qwe by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF 4-GUANIDINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWC
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BU of 2qwc by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWB
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BU of 2qwb by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF SIALIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWD
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BU of 2qwd by Molmil
THE X-RAY STRUCTURE OF A COMPLEX OF 4-AMINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, ...
著者Varghese, J.N.
登録日1998-04-07
公開日1998-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
6DLM
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BU of 6dlm by Molmil
DHD127
分子名称: DHD127_A, DHD127_B
著者Bick, M.J, Chen, Z, Baker, D.
登録日2018-06-01
公開日2018-12-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.753 Å)
主引用文献Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
6DMA
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BU of 6dma by Molmil
DHD15_closed
分子名称: DHD15_closed_A, DHD15_closed_B
著者Bick, M.J, Chen, Z, Baker, D.
登録日2018-06-04
公開日2018-12-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.363 Å)
主引用文献Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
6DKM
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BU of 6dkm by Molmil
DHD131
分子名称: DHD131_A, DHD131_B
著者Bick, M.J, Chen, Z, Baker, D.
登録日2018-05-29
公開日2018-12-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
6DM9
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BU of 6dm9 by Molmil
DHD15_extended
分子名称: DHD15_extended_A, DHD15_extended_B, SULFATE ION
著者Bick, M.J, Chen, Z, Baker, D.
登録日2018-06-04
公開日2018-12-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019

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