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7Z4O
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BU of 7z4o by Molmil
Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Pflug, A.
登録日2022-03-04
公開日2022-05-11
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.412 Å)
主引用文献Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
6QCX
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BU of 6qcx by Molmil
Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer
分子名称: MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCV
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BU of 6qcv by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP
分子名称: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCS
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BU of 6qcs by Molmil
Influenza B polymerase pre-initiation complex
分子名称: 3 end, 5 end, Capped RNA, ...
著者Cusack, S, Kouba, T.
登録日2018-12-30
公開日2019-06-05
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCT
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BU of 6qct by Molmil
Influenza B polymerase elongation complex
分子名称: 3 end, 5 end, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2018-12-30
公開日2019-06-05
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCW
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BU of 6qcw by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
8P0G
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BU of 8p0g by Molmil
Thogoto virus polymerase in Mode A conformation and bound to 35-mer loop promoter RNA
分子名称: 5'RNA, MAGNESIUM ION, Polymerase acidic protein, ...
著者Cusack, S, Kouba, T.
登録日2023-05-10
公開日2024-05-22
最終更新日2025-07-09
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Thogoto virus polymerase
To Be Published
8P0B
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BU of 8p0b by Molmil
Thogoto virus polymerase in Mode B conformation and bound to 32-mer loop promoter RNA
分子名称: 3'RNA, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Kouba, T.
登録日2023-05-10
公開日2024-05-22
最終更新日2025-07-09
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Thogoto virus polymerase
To Be Published
8P0U
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BU of 8p0u by Molmil
Thogoto virus polymerase in Mode B conformation with defined endonuclease domain and bound to 32-mer loop promoter RNA
分子名称: 3'RNA, MAGNESIUM ION, Polymerase acidic protein, ...
著者Cusack, S, Kouba, T.
登録日2023-05-10
公開日2024-05-22
最終更新日2025-07-09
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Thogoto virus polymerase
To Be Published
1H4V
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BU of 1h4v by Molmil
HISTIDYL-TRNA SYNTHETASE from Thermus Thermophilus (ligand free)
分子名称: HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S, Yaremchuk, A, Tukalo, M.
登録日2001-05-14
公開日2001-06-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
6FSB
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BU of 6fsb by Molmil
Influenza B/Memphis/13/03 endonuclease with I38T mutation
分子名称: MAGNESIUM ION, MANGANESE (II) ION, Polymerase acidic protein
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS8
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BU of 6fs8 by Molmil
Influenza B/Memphis/13/03 endonuclease with bound inhibitor, baloxavir acid (BXA)
分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS6
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BU of 6fs6 by Molmil
Influenza A/California/04/2009 (pH1N1) endonuclease with bound inhibitor, baloxavir acid (BXA)
分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.291 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS9
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BU of 6fs9 by Molmil
Influenza B/Memphis/13/03 endonuclease with I38T mutation with bound inhibitor, baloxavir acid (BXA)
分子名称: Baloxavir acid, CHLORIDE ION, MANGANESE (II) ION, ...
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
6FS7
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BU of 6fs7 by Molmil
Influenza A/California/04/2009 (pH1N1) endonuclease with I38T mutation with bound inhibitor, baloxavir acid (BXA)
分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein
著者Cusack, S, Speranzini, V.
登録日2018-02-19
公開日2018-07-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
Sci Rep, 8, 2018
7QTL
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BU of 7qtl by Molmil
Influenza A/H7N9 polymerase elongation complex
分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
著者Cusack, S, Kouba, T.
登録日2022-01-14
公開日2022-12-28
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (2.48 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7R1F
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BU of 7r1f by Molmil
Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-02-02
公開日2022-12-28
最終更新日2025-07-09
実験手法ELECTRON MICROSCOPY (2.58 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7R0E
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BU of 7r0e by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-02-01
公開日2022-12-28
最終更新日2025-07-09
実験手法ELECTRON MICROSCOPY (2.51 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
2BTE
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BU of 2bte by Molmil
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation and a post- transfer editing substrate analogue
分子名称: 2'-AMINO-2'-DEOXYADENOSINE, AMINOACYL-TRNA SYNTHETASE, LEUCINE, ...
著者Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S.
登録日2005-05-31
公開日2005-09-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer- Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
2BYT
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BU of 2byt by Molmil
Thermus thermophilus Leucyl-tRNA synthetase complexed with a tRNAleu transcript in the post-editing conformation
分子名称: LEUCINE, LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, ...
著者Cusack, S, Tukalo, M, Yaremchuk, A, Fukunaga, R, Yokoyama, S.
登録日2005-08-04
公開日2005-09-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The Crystal Structure of Leucyl-tRNA Synthetase Complexed with tRNA(Leu) in the Post-Transfer-Editing Conformation.
Nat.Struct.Mol.Biol., 12, 2005
1ADJ
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BU of 1adj by Molmil
HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE
分子名称: HISTIDINE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S, Aberg, A.
登録日1997-02-18
公開日1997-08-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
1ADY
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BU of 1ady by Molmil
HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDYL-ADENYLATE
分子名称: HISTIDYL-ADENOSINE MONOPHOSPHATE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
著者Cusack, S, Aberg, A.
登録日1997-02-19
公開日1997-08-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997
7ZPM
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BU of 7zpm by Molmil
Influenza A/H7N9 polymerase apo-protein dimer complex
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
著者Cusack, S, Kouba, T.
登録日2022-04-27
公開日2022-12-28
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (2.81 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7ZPL
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BU of 7zpl by Molmil
Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook
分子名称: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ...
著者Cusack, S, Kouba, T.
登録日2022-04-27
公開日2022-12-28
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
9F3V
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BU of 9f3v by Molmil
RIP2K kinase domain dimer with bound compound 37 (N399), a speific NOD1 pathway inhibitor
分子名称: N-[2,4-bis(chloranyl)-5-methoxy-phenyl]-7-[2-(diethylamino)ethoxy]-6-methoxy-quinazolin-4-amine, Receptor-interacting serine/threonine-protein kinase 2
著者Cusack, S, Huard, K, Pellegrini, E.
登録日2024-04-26
公開日2024-11-06
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (1.943 Å)
主引用文献4-Anilinoquinazoline Derivatives as the First Potent NOD1-RIPK2 Signaling Pathway Inhibitors at the Nanomolar Range.
J.Med.Chem., 67, 2024

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件を2025-07-09に公開中

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