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Crystal structure of YTHDC1 in complex with Compound 12 (ZA_341)
分子名称:	9-[(2-aminophenyl)methyl]-2-chloranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.32 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q2Y

Crystal structure of YTHDC1 in complex with Compound 11 (ZA_572)
分子名称:	2-[2-chloranyl-6-(methylamino)purin-9-yl]-~{N}-phenyl-ethanamide, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.71 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q4P

Crystal structure of YTHDC1 in complex with Compound 27 (ZA_309)
分子名称:	2-chloranyl-9-[(3-methoxyphenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-07
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.43 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q3G

Crystal structure of YTHDC1 in complex with Compound 23 (ZA_385)
分子名称:	3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]-~{N}-methyl-benzamide, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-04
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q4W

Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a)
分子名称:	5-chloranyl-3-[(3-chlorophenyl)methyl]-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-07
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.61 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q2X

Crystal structure of YTHDC1 in complex with Compound 10 (ZA_294)
分子名称:	3-[2-chloranyl-6-(methylamino)purin-9-yl]benzoic acid, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q3A

Crystal structure of YTHDC1 in complex with Compound 22 (ZA_393)
分子名称:	3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzamide, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.43 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q2S

Crystal structure of YTHDC1 in complex with Compound 4 (ZA_232)
分子名称:	2-chloranyl-~{N}-methyl-9-phenyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.41 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q4N

Crystal structure of YTHDC1 in complex with Compound 26 (ZA_513)
分子名称:	3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzenecarbonitrile, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-07
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q35

Crystal structure of YTHDC1 in complex with Compound 16 (ZA_354)
分子名称:	9-[[2-[bis(fluoranyl)methyl]phenyl]methyl]-2-chloranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.31 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q2V

Crystal structure of YTHDC1 in complex with Compound 7 (ZA_560)
分子名称:	2-chloranyl-~{N}-methyl-9-[(2~{S})-oxan-2-yl]purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.71 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q2U

Crystal structure of YTHDC1 in complex with Compound 6 (ZA_308)
分子名称:	2-chloranyl-~{N}-methyl-9-(pyridin-4-ylmethyl)purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.36 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q39

Crystal structure of YTHDC1 in complex with Compound 21 (ZA_515)
分子名称:	2-chloranyl-N-methyl-9-[[3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl]purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q37

Crystal structure of YTHDC1 in complex with Compound 18 (ZA_312)
分子名称:	2-chloranyl-9-[(2-methoxyphenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-03
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.28 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q4M

Crystal structure of YTHDC1 in complex with Compound 25 (ZA_349)
分子名称:	2-chloranyl-9-[(3-chlorophenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-07
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.43 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

8Q4T

Crystal structure of YTHDC1 in complex with Compound 31 (ZA_400)
分子名称:	SULFATE ION, YTH domain-containing protein 1, ~{N}-[4-chloranyl-2-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanesulfonamide
著者	Bedi, R.K, Zalesak, F, Caflisch, A.
登録日	2023-08-07
公開日	2023-12-06
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.51 Å)
主引用文献	Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024

5MP4

The structure of Pst2p from Saccharomyces cerevisiae
分子名称:	PHOSPHATE ION, Protoplast secreted protein 2
著者	Hromic, A, Gruber, K.
登録日	2016-12-15
公開日	2017-05-24
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.79 Å)
主引用文献	Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase. Biochim. Biophys. Acta, 1865, 2017

8BB7

Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Plexin-B1, VHH15 Nanobody
著者	Cowan, R, Hall, G, Carr, M.
登録日	2022-10-12
公開日	2023-05-03
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.95 Å)
主引用文献	Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. J.Biol.Chem., 299, 2023

8B3K

Crystal structure of human Plexin-B1 (20-535) in the unbound state
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Plexin-B1
著者	Cowan, R, Hall, G, Carr, M.
登録日	2022-09-16
公開日	2023-05-03
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.685 Å)
主引用文献	Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. J.Biol.Chem., 299, 2023

8BF4

Crystal structure of Mouse Plexin-B1 (20-535) in complex with VHH15 and VHH14
分子名称:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者	Cowan, R, Hall, G, Carr, M.
登録日	2022-10-24
公開日	2023-05-03
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.15 Å)
主引用文献	Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. J.Biol.Chem., 299, 2023

7OGJ

Crystal structure of human METTL1 in complex with SAH
分子名称:	CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者	Nai, F, Bedi, R.K, Caflisch, A.
登録日	2021-05-06
公開日	2021-05-19
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.59 Å)
主引用文献	Small-Molecule Inhibitors of the m7G-RNA Writer METTL1 Acs Bio Med Chem Au, 2023

7OTT

Metabolon-embedded pyruvate dehydrogenase complex E2 core at near-atomic resolution
分子名称:	Acetyltransferase component of pyruvate dehydrogenase complex
著者	Tueting, C, Kastritis, P.L.
登録日	2021-06-10
公開日	2021-12-01
最終更新日	2024-07-17
実験手法	ELECTRON MICROSCOPY (3.84 Å)
主引用文献	Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction. Nat Commun, 12, 2021

1I5K

STRUCTURE AND BINDING DETERMINANTS OF THE RECOMBINANT KRINGLE-2 DOMAIN OF HUMAN PLASMINOGEN TO AN INTERNAL PEPTIDE FROM A GROUP A STREPTOCOCCAL SURFACE PROTEIN
分子名称:	M PROTEIN, PLASMINOGEN
著者	Rios-Steiner, J.L, Schenone, M, Mochalkin, I, Tulinsky, A, Castellino, F.J.
登録日	2001-02-27
公開日	2001-08-01
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein. J.Mol.Biol., 308, 2001

6KLF

Crystal structure of branching enzyme D434A mutant from Cyanothece sp. ATCC 51142
分子名称:	1,4-alpha-glucan branching enzyme GlgB, GLYCEROL, MAGNESIUM ION
著者	Suzuki, R, Suzuki, E.
登録日	2019-07-30
公開日	2020-08-05
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Cyanobacterial branching enzymes bind to alpha-glucan via surface binding sites Arch.Biochem.Biophys., 702, 2021

7PL1

Crystal structure of human METTL1 bound to Sinefungin
分子名称:	DI(HYDROXYETHYL)ETHER, GLYCEROL, SINEFUNGIN, ...
著者	Nai, F, Caflisch, A.
登録日	2021-08-27
公開日	2021-09-15
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Small-Molecule Inhibitors of the m7G-RNA Writer METTL1 Acs Bio Med Chem Au, 2023

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